Serum sialic acid in malignant tumors, bacterial infections, and chronic liver diseases

Stefenelli, N; Klotz, Henry; Engel, Arthur; Bauer, Péter

doi:10.1007/bf01884255

Cited by 89 publications

(56 citation statements)

References 23 publications

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“…Alternatively, since TSA has been well described as being associated with the acute-phase protein response [17] , increased activity of serum or tissue sialidase in combination with inflammatory response could considerably elevate serum TSA levels in patients with CCA. Also, the difference between the ages of the CCA and HCC groups might be responsible for this discrepancy, since serum TSA concentration slightly increased with advancing age [18] . Nonetheless, the age-dependent difference between groups might not be sufficient to interfere with the discrimination of serum TSA values in our study.…”

Section: Discussionmentioning

confidence: 99%

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Kongtawelert

Tangkijvanich²,

Ongchai³

et al. 2003

WJG

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Section: Discussionmentioning

confidence: 99%

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Kongtawelert

Tangkijvanich²,

Ongchai³

et al. 2003

WJG

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“…Sialic acid (SA) is a derivative of neuroaminic acid [16,17] and abundantly present in all cell membranes [17][18][19][20] . It has been reported that SA concentration had increased rapidly in the pathologic conditions like inflammation, tissue destruction, and tissue proliferation [17] .…”

Section: Introductionmentioning

confidence: 99%

“…Due to this fact, evaluation of SA concentration may be an important sign in the diagnosis of inflammatory diseases [19,[21][22][23][24] . Although the mechanism in the increase of serum SA level during the inflammatory conditions is not clear, many investigators indicated the role of AFPs which share the same structure with SA [17,19,20,25] . Since acute phase reactants are glycoprotein in structure, it has been reported that increase in these proteins affects the TSA levels [20] but not reflects the increases in SA levels exactly, which also bears glycoprotein structure [19] .…”

Section: Introductionmentioning

confidence: 99%

“…Increase in the free radical levels also cause increases in the catabolic reactions in cells for the protection of homeostasis in the organisms [15] . Increased free radical levels cause cell and tissue destructions in the organism and elicits a status called "oxidative stress" [4,14,15] .Sialic acid (SA) is a derivative of neuroaminic acid [16,17] and abundantly present in all cell membranes [17][18][19][20] . It has been reported that SA concentration had increased rapidly in the pathologic conditions like inflammation, tissue destruction, and tissue proliferation [17] .…”

mentioning

confidence: 99%

“…It has been reported that SA concentration had increased rapidly in the pathologic conditions like inflammation, tissue destruction, and tissue proliferation [17] . Due to this fact, evaluation of SA concentration may be an important sign in the diagnosis of inflammatory diseases [19,[21][22][23][24] . Although the mechanism in the increase of serum SA level during the inflammatory conditions is not clear, many investigators indicated the role of AFPs which share the same structure with SA [17,19,20,25] .…”

mentioning

confidence: 99%

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Laminektomi Yapılan Tavşanlarda Alfa-lipoik Asit Uygulamalarının Total Antioksidan Kapasite, Total Oksidan Kapasite, Paraoksonaz ve Total Sialik Asit Düzeyleri Üzerine Etkilerinin Araştırılması

Yildirim¹,

Yücetaş²,

Kaya³

et al. 2014

Kafkas Univ Vet Fak Derg

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The objective of this study is to investigate the effect of intramuscular administration of alpha-lipoic acid (ALA) on total antioxidant (TAS), total oxidant (TOS), paraoxonase (PON) and total sialic acid (TSA) levels in laminectomized rabbits. In the study, twenty four white New Zeeland rabbits weighing 3-4 kg were used. The investigation was carried out with three experiment and one control group consisting of six animals of each. No intervention has been done to the control group. Animals in the Group I received 50 mg/kg/day IM ALA (Thioctacid 600 T, M, EDA, Hamburg) without undergoing laminectomy. Group II underwent laminectomy; Group III underwent laminectomy and treated with IM ALA. The experiment lasted 45 days and blood samples were taken on 0, 15 th , 30 th , and 45 th days from the animals. TAS, TOS, PON and TSA levels were measured in the serum. We conclude that ALA treatment would be beneficial in laminectomized rabbits in order to suppress inflammatory process and to expedite recovery. Keywords: ALA, Laminectomy, TAS, TOS, PON, TSA, RabbitLaminektomi Yapılan Tavşanlarda Alfa-lipoik Asit Uygulamalarının Total Antioksidan Kapasite, Total Oksidan Kapasite, Paraoksonaz ve Total Sialik Asit Düzeyleri Üzerine Etkilerinin Araştırılması ÖzetBu çalışma, laminektomi yapılan tavşanlarda intramüsküler Alfa Lipoik Asit (ALA) uygulamasının total antioksidan kapasite (TAS), total oksidan kapasite (TOS), paraoksonaz (PON), ve total sialik asit (TSA) düzeylerini üzerine olan etkilerini araştırmak amacı ile yapıldı. Çalışmada, 3.5-4 kg ağırlığında 24 adet beyaz Yeni Zelanda erkek tavşan kullanıldı. Araştırma, herbiri 6 adet hayvan içeren 1 kontrol ve 3 deneme grubu olmak üzere 4 grup halinde yürütüldü. Kontrol grubuna hiçbir müdahale yapılmadı. Grup I'deki hayvanlara laminektomi yapılmaksızın 50 mg/ kg/gün İM ALA (Thioctacid 600 T, M EDa, Hamburg, Germany) enjekte edildi. Grup II'deki hayvanlara sadece laminektomi yapıldı. Grub III'e İM ALA+laminektomi uygulandı. Deneme toplamda 45 gün sürdürüldü. Denemenin 0., 15., 30.,ve 45. günlerinde vena auricularisten kan alındı. Elde edilen serum örneklerinde TAS, TOS, PON ve TSA düzeyleri belirlendi. Sonuç olarak, laminektomi yapılan tavşanlarda yangısal sürecin baskılanması ve iyileşmenin hızlandırılması için eksojen ALA kullanılmasının faydalı olabileceği kanısına varıldı. Anahtar sözcükler: ALA, Laminektomi, TAS, TOS, PON, TSA, Tavşan Investigation of the Effects of Alpha Lipoic Acid Application on INTRODUCTIONAlpha lipoic acid (ALA) has been described as a potent biologic antioxidant, a detoxifying agent, and a medicine for diabetes. It is used for the treatment of age-related cardiovascular and neuromuscular insufficiencies, and plays an important role as a modulator in various inflammatory signal pathways. Effect of ALA on inflammation originated from cytokines have been investigated and has been discovered that it was an inhibitor of NF-kappa β [1] , matrix metalloproteinase-13 (MMP-13) and growth factor-p (TGF J-3) [1] . It has been reported that antioxidant property...

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Total and lipid-associated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement

Plucinsky

Riley

Prorok

et al. 1986

Cancer

100

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Serum total sialic acid (TSA) and lipid-associated sialic acid (LASA) levels have drawn considerable interest because of carbohydrate aberrations in malignant cells. The current investigation determined the TSA, LASA, total protein (TP), and TSA/TP values for 171 cancer patients with various primary sites and differing degrees of metastatic disease, 102 patients with nonmalignant diseases (pathologic controls), and 42 normal individuals. Data analysis indicated significant (p less than 0.01) increases in the mean (+/- SD) TSA and TSA/TP values in the cancer patients (78.1 +/- 19.2 mg/dl and 12.4 +/- 3.8 mg/g, respectively) and in the pathologic controls (76.0 +/- 7.5 mg/dl and 11.6 +/- 2.5 mg/g) when compared to the normal controls (67.3 +/- 7.1 mg/dl and 9.0 +/- 1.1 mg/g), and a significant decrease in the mean TP values in the cancer patients (6.4 +/- 1.1 g/dl) and pathologic controls (6.6 +/- 1.1 g/dl) when compared to normal controls (7.5 +/- 0.5 g/dl). No significant difference was observed between groups in LASA values. Further analysis of the data in patient subgroups based on the tissue involved, specific disease, or severity of the malignancy indicated that the lack of specificity of the markers was due primarily to restricted subgroups and that the sensitivity of TSA and TSA/TP increased as the malignancy became more severe. The results show that TSA/TP was the most useful of the markers tested for detecting malignancies. This marker should prove useful for monitoring malignant disease recurrence and/or progression and for evaluating the effectiveness of various therapeutic approaches.

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Serum sialic acid in malignant tumors, bacterial infections, and chronic liver diseases

Cited by 89 publications

References 23 publications

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Laminektomi Yapılan Tavşanlarda Alfa-lipoik Asit Uygulamalarının Total Antioksidan Kapasite, Total Oksidan Kapasite, Paraoksonaz ve Total Sialik Asit Düzeyleri Üzerine Etkilerinin Araştırılması

Total and lipid-associated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement

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