Total and lipid-associated serum sialic acid levels in cancer patients with different primary sites and differing degrees of metastatic involvement

Abstract

Serum total sialic acid (TSA) and lipid-associated sialic acid (LASA) levels have drawn considerable interest because of carbohydrate aberrations in malignant cells. The current investigation determined the TSA, LASA, total protein (TP), and TSA/TP values for 171 cancer patients with various primary sites and differing degrees of metastatic disease, 102 patients with nonmalignant diseases (pathologic controls), and 42 normal individuals. Data analysis indicated significant (p less than 0.01) increases in the mean (+/- SD) TSA and TSA/TP values in the cancer patients (78.1 +/- 19.2 mg/dl and 12.4 +/- 3.8 mg/g, respectively) and in the pathologic controls (76.0 +/- 7.5 mg/dl and 11.6 +/- 2.5 mg/g) when compared to the normal controls (67.3 +/- 7.1 mg/dl and 9.0 +/- 1.1 mg/g), and a significant decrease in the mean TP values in the cancer patients (6.4 +/- 1.1 g/dl) and pathologic controls (6.6 +/- 1.1 g/dl) when compared to normal controls (7.5 +/- 0.5 g/dl). No significant difference was observed between groups in LASA values. Further analysis of the data in patient subgroups based on the tissue involved, specific disease, or severity of the malignancy indicated that the lack of specificity of the markers was due primarily to restricted subgroups and that the sensitivity of TSA and TSA/TP increased as the malignancy became more severe. The results show that TSA/TP was the most useful of the markers tested for detecting malignancies. This marker should prove useful for monitoring malignant disease recurrence and/or progression and for evaluating the effectiveness of various therapeutic approaches.

A Study of Total Sialic Acid and Lipid Bound Sialic Acid Levels and Total Sialic Acid to Total Protein Ratio in Cancer Patients

“…When the cancer patients were subdivided according to severity of disease, the highest levels of TSA were found for the most advanced stages of malignancy. 20 In the present study, the mean ± SD of lipid bound sialic acid in healthy controls is 17.80 ± 3.671, pathological controls is 30.70 ± 2.902, cancer without metastasis is 31.50 ± 2.596 and cancer with metastasis is 39.17 ± 4.136. The increase was significant (p=0.0001).…”

Comparative Evaluation of the Anti-ulcer Activity of Curcumin and Omeprazole during the Acute Phase of Gastric Ulcer—Efficacy of Curcumin in Gastric Ulcer Prevention against Omeprazole

“…The acids in the reagent hydrolyze the complex glycoprotein of the gastric juice mucin to release N-acetylneuraminic acid (NANA) that then reacts with the resorcinol reagent to develop the color that directly proportionates with its concentration [20]. Resorcinol Reagent prepared by adding 10 mL of 2%, w/v, resorcinol in distilled water +9.75 mL distilled water +0.25 mL 0.1 M CuSO 4 in distilled water and complete to 100 mL with concentrated HCl.…”

Glycoprotein components in the serum of patients with cancer breast

“…The glycoprotein related parameters are well established as useful markers for diagnosis of various types of cancers (15,16). However, none of these investigators have studied all the three parameters together as a possible tool in the diagnosis or prognosis of breast tumours.…”