Serum serotonin, leptin, and adiponectin changes in women with postpartum depression: controlled study

Yıldız, Gazi; Şentürk, Mehmet Baki; Yıldız, Pınar; Çakmak, Yusuf; Budak, Mehmet Şükrü; Cakar, Erbil

doi:10.1007/s00404-017-4313-0

Cited by 27 publications

(18 citation statements)

References 27 publications

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“…In depressed animals, the level of monoamines neurotransmitters will be decreased and therefore most of the current antidepressant drugs used apply the concept of alteration of monoamine neurotransmitter concentration levels [ 36 ]. Low level of serotonin has been found to increase the risk of depression in susceptible postpartum women [ 37 ]. In postpartum depressed rats, the concentration of serotonin was suppressed [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Antidepressant-Like Properties of Fish Oil on Postpartum Depression-Like Rats Model: Involvement of Serotonergic System

et al. 2020

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Pathophysiology of postpartum depression (PPD) has been associated with many factors, such as neuroendocrine, neuroinflammation and neurotransmitter changes. Fish oil (FO) improves PPD both in humans and animals. However, little is known with regards to its pharmacology on a PPD-like rat model. Hence, the current study aimed at investigating the effects of FO on a PPD-like rat model. Female rats were induced with PPD-like symptoms and then randomly divided into six groups (n = 6) for two experimental protocols. Protocol 1 consisted of PPD-like rats (2 mL distilled water), PPD-like + FO (9 g/kg/d) and PPD-like + Fluoxetine (FLX) (15 mg/kg/d) groups of rats, whereas Protocol 2 consisted of PPD-like rats (2 mL distilled water) + PCPA (p-chlorophenylalanine) 150 mg/kg, PPD-like + FO (9 g/kg/d) + PCPA 150 mg/kg and PPD-like + FLX (15 mg/d) + PCPA 150 mg/kg groups of rats, respectively. All treatments were administered orally for 10 days postpartum, except PCPA, which was given intraperitoneally. Prior to euthanasia, the antidepressant-like effect of the FO was evaluated using the forced swimming test (FST) and open field test (OFT) on day 10 postpartum. Biochemical analysis of serotonin, serotonin metabolite and serotonin turnover from their prefrontal cortex and hippocampus were also measured. The results showed that FO decreased immobility time and increased swimming time significantly, but not climbing time in FST. Further, it also decreased serotonin metabolite and turnover significantly in the hippocampus of the PPD-like rats. In contrast, administration with PCPA reversed all the outcomes. The antidepressant-like effects of FO were found to be similar with that of FLX. Thus, it can be concluded that FO exerts its antidepressant-like effects in PPD-like rats through modulation of serotonergic system.

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Section: Discussionmentioning

confidence: 99%

Antidepressant-Like Properties of Fish Oil on Postpartum Depression-Like Rats Model: Involvement of Serotonergic System

et al. 2020

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“…Generally, Adiponectin applies its effect by expressing the receptors in the cerebral, cortex, hypothalamus, and hippocampus [18]. These hormonal secretions and expressions protect the neurons, motivate neurogenesis, and apply anti-depressant effects which can lead to a better mental function [19,20].…”

Section: Discussionmentioning

confidence: 99%

Biological reflect of Adiponectin hormone in postpartum marital satisfaction and depression scores

Pahlavan

Kazemnejad

Razavinia

et al. 2020

BMC Pregnancy Childbirth

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Background There is a growing body of evidence regarding the association between Adiponectin and mental disorders. We aim to evaluate the association between serum level of Adiponectin hormone and postpartum depression and marital satisfaction scores. Methods A prospective cohort study of 90 pregnant women was conducted in Mahdieh Hospital, Tehran, Iran. Blood samples were collected during the first 24 h after delivery. The serum Adiponectin concentration was measured with an Enzyme-Linked Immunosorbent Assay (ELISA) kit. The depression score was measured using a validated Iranian version of the Edinburgh Postnatal Depression Scale (EPDS) questionnaire at six weeks (6-weeks) and twelve weeks (12-weeks) after delivery. Using the Kansas questionnaire at twelve weeks (12-weeks) after delivery, the marital satisfaction score was measured. The measurements were compared between two groups, satisfied and dissatisfied mothers. P-values lower than 0.05 were considered significant. Results The mean serum level of Adiponectin was significantly higher in the dissatisfied group. It was 10.9 ± 13.4 μg/ml and 15.2 ± 17.7 μg /ml in the satisfied and dissatisfied groups, respectively (P = 0.04). The postpartum depression scores of 6- and 12-weeks after delivery were significantly higher in the dissatisfied group. At 6-weeks after delivery, the postpartum depression scores were 3.6 ± 3 and 8.7 ± 5.6 in satisfied and dissatisfied groups, respectively. Those were 2.7 ± 2.7 and 7.6 ± 5 at 12-weeks after delivery, respectively. There was a significant difference statistically (P < 0.001). Conclusion Mothers in the dissatisfied group, experienced higher depression scores at 12-weeks postpartum while they had shown higher serum Adiponectin levels at the first 24 h after delivery.

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“…Regarding adipokines in perinatal depression, lower adiponectin levels have been associated with postpartum depression by at least one group 71 ; however a second group that followed women throughout pregnancy and the postpartum period did not observe this association 55 . While the first of these two studies 71 also examined leptin levels and found no concurrent relationship with postpartum depression, others have reported that reduced serum leptin after delivery predicts the later development of postpartum depression 72 .…”

Section: Depression and Inflammation In The Perinatal Periodmentioning

confidence: 97%

“…While the first of these two studies 71 also examined leptin levels and found no concurrent relationship with postpartum depression, others have reported that reduced serum leptin after delivery predicts the later development of postpartum depression 72 .…”

Section: Depression and Inflammation In The Perinatal Periodmentioning

confidence: 99%

Roles of Inflammation and Depression in the Development of Gestational Diabetes

Robakis

Aasly

Williams

et al. 2017

Curr Behav Neurosci Rep

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Inflammation, the body’s response to harmful external agents, has long been found to be associated with depressive symptoms. The relationship between inflammation and depression is well established in the general population of people with depression, but is less so among perinatal women. Depression in the perinatal period is a common disorder, however available data do not indicate that there is a specific inflammatory picture associated with perinatal depression. We suggest that perinatal depression may be a heterogeneous construct, and that inflammation may be relevant to it in the context of other inflammatory morbidities of pregnancy. In this review we explore the available support for the hypothesis that inflammation associated with depression can represent a precipitating insult for the development of gestational diabetes, a known inflammatory morbidity of pregnancy.

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Serum serotonin, leptin, and adiponectin changes in women with postpartum depression: controlled study

Abstract: The serum adiponectin and leptin levels were high in women with PPD. This could play important role in the pathophysiology of PPD. Elevation of serum levels also may play antidepressant role against PPD, especially the early postpartum period.

Cited by 27 publications

References 27 publications

Antidepressant-Like Properties of Fish Oil on Postpartum Depression-Like Rats Model: Involvement of Serotonergic System

Antidepressant-Like Properties of Fish Oil on Postpartum Depression-Like Rats Model: Involvement of Serotonergic System

Biological reflect of Adiponectin hormone in postpartum marital satisfaction and depression scores

Roles of Inflammation and Depression in the Development of Gestational Diabetes

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