Biological reflect of Adiponectin hormone in postpartum marital satisfaction and depression scores

Abstract

Background There is a growing body of evidence regarding the association between Adiponectin and mental disorders. We aim to evaluate the association between serum level of Adiponectin hormone and postpartum depression and marital satisfaction scores. Methods A prospective cohort study of 90 pregnant women was conducted in Mahdieh Hospital, Tehran, Iran. Blood samples were collected during the first 24 h after delivery. The serum Adiponectin concentration was measured with an Enzyme-Linked Immunosorbent Assay (ELISA) kit. The depression score was measured using a validated Iranian version of the Edinburgh Postnatal Depression Scale (EPDS) questionnaire at six weeks (6-weeks) and twelve weeks (12-weeks) after delivery. Using the Kansas questionnaire at twelve weeks (12-weeks) after delivery, the marital satisfaction score was measured. The measurements were compared between two groups, satisfied and dissatisfied mothers. P-values lower than 0.05 were considered significant. Results The mean serum level of Adiponectin was significantly higher in the dissatisfied group. It was 10.9 ± 13.4 μg/ml and 15.2 ± 17.7 μg /ml in the satisfied and dissatisfied groups, respectively (P = 0.04). The postpartum depression scores of 6- and 12-weeks after delivery were significantly higher in the dissatisfied group. At 6-weeks after delivery, the postpartum depression scores were 3.6 ± 3 and 8.7 ± 5.6 in satisfied and dissatisfied groups, respectively. Those were 2.7 ± 2.7 and 7.6 ± 5 at 12-weeks after delivery, respectively. There was a significant difference statistically (P < 0.001). Conclusion Mothers in the dissatisfied group, experienced higher depression scores at 12-weeks postpartum while they had shown higher serum Adiponectin levels at the first 24 h after delivery.

Evaluation of couple's sexual function after childbirth with the biopsychosocial model: A systematic review of systematic reviews and meta-analysis

“…[ 19 24 ] PPD prevalence is 19.20%, and multifactorial conditions can affect it. [ 15 34 ] Hormonal conditions can cause mood changes, and many have hypothesized the role of sex hormones in PPD because of the temporary communication between the fundamental and rapid changes in the hormone concentrations which occur during childbirth and the onset of depressive symptoms. In the forebrain, hippocampus, and cerebral cortex, estradiol, and progesterone increases Brain-Derived Neurotrophic Factor (BDNF) levels which decreases in depression and increases with antidepressants.…”