Serum selenium levels are associated with age-related cataract

Post, M.H.; Lubiński, Wojciech; Lubiński, Jan; Krzystolik, Karol; Baszuk, Piotr; Muszyńska, Magdalena; Marciniak, Wojciech

doi:10.26444/aaem/90886

Cited by 14 publications

(10 citation statements)

References 38 publications

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“…Serum selenium levels may differ among populations, depending on a number of factors, including, but not limited to, concentration of selenium in food. The concentration of this element in adult human blood serum depends on a person’s age [24]…”

Section: Selenium In Human Organismmentioning

confidence: 99%

Selenium–Fascinating Microelement, Properties and Sources in Food

2019

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Selenium is a micronutrient that is essential for the proper functioning of all organisms. Studies on the functions of selenium are rapidly developing. This element is a cofactor of many enzymes, for example, glutathione peroxidase or thioredoxin reductase. Insufficient supplementation of this element results in the increased risk of developing many chronic degenerative diseases. Selenium is important for the protection against oxidative stress, demonstrating the highest activity as a free radical scavenger and anti-cancer agent. In food, it is present in organic forms, as exemplified by selenomethionine and selenocysteine. In dietary supplementation, the inorganic forms of selenium (selenite and selenate) are used. Organic compounds are more easily absorbed by human organisms in comparison with inorganic compounds. Currently, selenium is considered an essential trace element of fundamental importance for human health. Extreme selenium deficiencies are widespread among people all over the world. Therefore, it is essential to supplement the deficiency of this micronutrient with selenium-enriched food or yeast cell biomass in the diet.

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Section: Selenium In Human Organismmentioning

confidence: 99%

Selenium–Fascinating Microelement, Properties and Sources in Food

2019

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“…These studies were all able to indicate the close relationship between trace elements and cataract. However, recently Post et al found that low serum selenium levels maybe a risk factor of age-related cataract (31). This is in contrast to previous findings, perhaps indicating that the effect of selenium on cataract remains to be explored in a deeper step.…”

Section: Introductionmentioning

confidence: 79%

Selenium intake help prevent age-related cataract formation: Evidence from NHANES 2001–2008

Liu

Zhao

et al. 2023

Front. Nutr.

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IntroductionCataract is one of the leading causes of blindness and visual impairment, about 16 million people around the world. Trace elements play an important role in a variety of the processes in human body. This study aimed to investigate the association between daily dietary intake of trace elements and age-related cataract incidence based on data from the National Health and Nutrition Examination Survey (NHANES) 2001–2008.MethodsIron, zinc, copper, and selenium were conducted in this study among subjects aged 50 years and older for African Americans and 55 and older in US adults. Multivariate logistic regression analysis was used in different models to investigate the association of trace elements intake and cataract.ResultsAfter screening, 7,525 subjects were ultimately included in this study. A significant negative association was found between selenium intake and cataract incidence in adjusted models using multivariate logistic regression analysis (model 1: OR = 0.998, 95% CI = 0.997–1.000; model 2: OR = 0.997, 95% CI = 0.995–1.000; and model 3: OR = 0.998, 95% CI = 0.995–1.000). After dividing selenium intake into quintiles, significant negative associations between selenium intake and cataract were observed in the first quintile of model 3, the fourth and fifth quintiles of all models. In subgroup analyses adjusted for age and sex, a significant negative association was observed only in women aged 65–74 years.DiscussionOur study points out that maintaining daily dietary selenium intake at higher levels is helpful for cataract prevention, and that increasing daily dietary selenium intake in American women aged 65–74 years may contribute to the prevention of age-related cataract. The intakes of iron, zinc, copper may not be associated with age-related cataract.

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“…Human beings must consume around 55 micrograms of Se per day and not exceed the maximum limit of 400 micrograms per day [42]. The World Health Organization recommends a daily average intake of 55 µg of Se, while the recommendation is varied with age, gender, diet and geographic location [43]. The International Food and Nutrition Board has recommended an average daily intake of 40-70 µg Se and 45-55 µg Se for men and women, respectively, and 25 µg Se for children [2,44].…”

Section: Selenium Toxicity 231 Toxicity In Humans and Animalsmentioning

confidence: 99%

Selenium Biofortification: Roles, Mechanisms, Responses and Prospects

et al. 2021

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The trace element selenium (Se) is a crucial element for many living organisms, including soil microorganisms, plants and animals, including humans. Generally, in Nature Se is taken up in the living cells of microorganisms, plants, animals and humans in several inorganic forms such as selenate, selenite, elemental Se and selenide. These forms are converted to organic forms by biological process, mostly as the two selenoamino acids selenocysteine (SeCys) and selenomethionine (SeMet). The biological systems of plants, animals and humans can fix these amino acids into Se-containing proteins by a modest replacement of methionine with SeMet. While the form SeCys is usually present in the active site of enzymes, which is essential for catalytic activity. Within human cells, organic forms of Se are significant for the accurate functioning of the immune and reproductive systems, the thyroid and the brain, and to enzyme activity within cells. Humans ingest Se through plant and animal foods rich in the element. The concentration of Se in foodstuffs depends on the presence of available forms of Se in soils and its uptake and accumulation by plants and herbivorous animals. Therefore, improving the availability of Se to plants is, therefore, a potential pathway to overcoming human Se deficiencies. Among these prospective pathways, the Se-biofortification of plants has already been established as a pioneering approach for producing Se-enriched agricultural products. To achieve this desirable aim of Se-biofortification, molecular breeding and genetic engineering in combination with novel agronomic and edaphic management approaches should be combined. This current review summarizes the roles, responses, prospects and mechanisms of Se in human nutrition. It also elaborates how biofortification is a plausible approach to resolving Se-deficiency in humans and other animals.

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Serum selenium levels are associated with age-related cataract

Abstract: Due to a confirmed association between serum selenium levels and age-related cataract, low serum selenium levels may constitute a potential risk factor of age-related cataract.

Cited by 14 publications

References 38 publications

Selenium–Fascinating Microelement, Properties and Sources in Food

Selenium–Fascinating Microelement, Properties and Sources in Food

Selenium intake help prevent age-related cataract formation: Evidence from NHANES 2001–2008

Selenium Biofortification: Roles, Mechanisms, Responses and Prospects

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