Serum Selenium Level in Patients with Chronic Liver Disease

Galal, Ghada Moustafa; Ahmad, Nagwa Sayed; Mohammad, Ahmad M.; Bakrey, Rahma

doi:10.21608/smj.2017.40037

Cited by 3 publications

(3 citation statements)

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“…The liver is one of the organs with the highest selenium concentration [87]. Clinical data suggest that patients suffering from chronic liver diseases such as hepatic steatosis and cirrhosis have much lower concentrations of plasma selenium [88]. Chronic selenium supplementation recovers hepatic dysfunction; selenium is thus described as a hepatic protective factor [89].…”

Section: Elementsmentioning

confidence: 99%

Trace Elements, PPARs, and Metabolic Syndrome

Shi

Zou

Shen

et al. 2020

IJMS

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Metabolic syndrome (MetS) is a constellation of metabolic derangements, including central obesity, insulin resistance, hypertension, glucose intolerance, and dyslipidemia. The pathogenesis of MetS has been intensively studied, and now many factors are recognized to contribute to the development of MetS. Among these, trace elements influence the structure of proteins, enzymes, and complex carbohydrates, and thus an imbalance in trace elements is an independent risk factor for MetS. The molecular link between trace elements and metabolic homeostasis has been established, and peroxisome proliferator-activated receptors (PPARs) have appeared as key regulators bridging these two elements. This is because on one hand, PPARs are actively involved in various metabolic processes, such as abdominal adiposity and insulin sensitivity, and on the other hand, PPARs sensitively respond to changes in trace elements. For example, an iron overload attenuates hepatic mRNA expression of Ppar-α; zinc supplementation is considered to recover the DNA-binding activity of PPAR-α, which is impaired in steatotic mouse liver; selenium administration downregulates mRNA expression of Ppar-γ, thereby improving lipid metabolism and oxidative status in the liver of high-fat diet (HFD)-fed mice. More importantly, PPARs' expression and activity are under the control of the circadian clock and show a robust 24 h rhythmicity, which might be the reasons for the side effects and the clinical limitations of trace elements targeting PPARs. Taken together, understanding the casual relationships among trace elements, PPARs' actions, and the pathogenesis of MetS is of great importance. Further studies are required to explore the chronopharmacological effects of trace elements on the diurnal oscillation of PPARs and the consequent development of MetS.

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Section: Elementsmentioning

confidence: 99%

Trace Elements, PPARs, and Metabolic Syndrome

Shi

Zou

Shen

et al. 2020

IJMS

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“…It is not possible to say that selenium scarce is cause of chronic hepatitis or rheumatoid arthritis, but the severity of these diseases depends on element concentration in the body (Knyazeva et. al., 2016;Galal et. al., 2017).…”

Section: Ukrainian Journal Of Ecology 10(4) 2020mentioning

confidence: 99%

Selenium in natural environment and food chains. A Review

Sobolev¹,

Gutyj²,

Соболева³

2020

Ukr J Ecol

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The analytical review attempts to summarize the results of numerous scientific research conducted by scientists around the world on selenium scattering and accumulation in natural environment, with considerable attention paid to the concentration of this trace element in soils, natural waters and plants. It is shown that selenium content in agricultural products is caused by the processes of physico-chemical and biogenic migration of this element in the biogeochemical food chain. According to the modern classification of trace elements, which is based on their biological significance for living organisms, selenium belongs to the vital group or biogenic elements. As a biotic element, it has unique physicochemical and biochemical properties and with adequately absorbed into the human body has a positive effect on a number of physiological processes. Various research shows that the majority of the world population (except in some regions) today consumes less selenium with the food than necessary and its consumption decreases every year. Insufficient selenium intake in the human body (less than 15–30 μg/day) leads to the development one of the hypomicroelementosis – hyposelenosis. Selenium deficiency is considered as a possible etiological factor in some cardiovascular, cancer, osteoarticular and neurodegenerative diseases that threaten to human life. Providing the human body with selenium in optimal amounts is one of the important conditions of nutrition. A number of countries have developed recommended selenium intake standards for the adults, which range from 55 to 120 μg/day. We can calculate the physiological need for selenium in children and adolescents by extrapolation. The most safe and effective way to maintain the necessary level of selenium for the human body can be achieved only through the poultry and livestock products by mandatory introduction of premixes containing highly effective biologically available selenium forms into animal feed. This will ensure a relatively high level of trace element in meat, eggs, and milk and would eliminate the cases of toxicosis in human population due to buffer effect of animal tissues.

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“…It is incorporated into selenoproteins that have a broad spectrum of pleiotropic effects, ranging from immune-enhancing, antioxidant, and anti-inflammatory effects to the production of the active thyroid hormone [ 28 ]. Clinical data suggest that patients suffering from chronic liver diseases, such as steatosis and cirrhosis have significantly lower plasma selenium concentrations [ 29 ]. Selenium supplementation has been found to restore liver function [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium as a predictor of metabolic syndrome in middle age women

Schneider-Matyka

Cybulska

Szkup

et al. 2023

Aging

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Background: Selenium plays an important role in metabolic homeostasis. It has been suggested that it may also affect the expression and activity of PPAR-γ. The aim of study was to analyze the relationships between these variables in the context of the health of women, for whom the risk of MetS increases with age. Material and Methods: The study involved 390 women in middle age. The stages of study: a survey-based part; anthropometric measurements; analysis of biological material (blood) in terms of glycemia, triglyceride, HDL, and selenium levels, as well as genetic analysis of the PPAR-γ polymorphisms. Results: It was found that selenium may moderate the effect of the G allele of the PPAR-γ gene on the occurrence of elevated waist circumference (OR=1.030, 95%CI 1.005-1.057, p=0.020); and the effect of the C (OR=1.077, 95%CI 1.009-1.149, p=0.026) and the G alleles (OR=1.052, 95%CI 1.025-1.080, p<0.000) on the odds of elevated blood pressure. Women in whom HDL levels were not significantly reduced, had higher selenium levels (p=0.007). Conclusions: 1. The effect of selenium on MetS and its components has not been demonstrated. 2. The effect of individual alleles of the PPAR-γ gene on MetS and its components was not demonstrated. 3. The concentration of selenium may affect waist circumference in carriers of the G allele, and arterial hypertension in carriers of the C and G alleles by affecting the expression of PPAR-γ. 4. Higher selenium concentrations increased the odds of higher HDL levels in the group of subjects meeting the MetS criteria.

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Serum Selenium Level in Patients with Chronic Liver Disease

Cited by 3 publications

References 1 publication

Trace Elements, PPARs, and Metabolic Syndrome

Trace Elements, PPARs, and Metabolic Syndrome

Selenium in natural environment and food chains. A Review

Selenium as a predictor of metabolic syndrome in middle age women

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