Serum selenium determinants in French adults: the SU.VI.M.AX study

Arnaud, Josiane; Bertrais, Sandrine; Roussel, Anne‐Marie; Arnault, Nathalie; Ruffieux, D.; Favier, Alain; Berthelin, S.; Estaquio, Carla; Galán, Pilar; Czernichow, Sébastien; Herçberg, Serge

doi:10.1079/bjn20051528

Cited by 96 publications

(84 citation statements)

References 45 publications

(77 reference statements)

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“…Our result is in opposition with most European surveys (Arnaud et al, 2006;Meplan et al, 2007;Ortega et al, 2012) or US populations (Bleys et al, 2009), in which obese patients have lower serum selenium concentration, but in agreement with Dewailly's survey of a French Polynesian sampling in which selenium concentration in blood was positively linked to BMI , the regression coefficient (β) being 0.02, i.e. ten times higher than in our study, among the controls (β=0.002).…”

Section: Discussioncontrasting

confidence: 60%

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren

Kitahara²,

González³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was 0.76 μg/g. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands (M=0.87 μg/g) and in the Tuamotu-Gambier Archipelago (M=0.86 μg/g). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

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Section: Discussioncontrasting

confidence: 60%

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren

Kitahara²,

González³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In the meantime, it would be reasonable to promote increased dietary intake of foods rich in selenium by individuals potentially most at risk of having suboptimal selenium levels, particularly young women, older men and those with low educational attainment. Two recent studies have shown associations between high selenium levels and fish and meat consumption in France and Britain (Arnaud et al, 2006;Bates et al, 2006), both countries with similar levels and estimates of depletion prevalence (10-50% o70 mg/l ) as Australia (Combs, 2001). …”

Section: Discussionmentioning

confidence: 98%

Selenium status in Southern Tasmania

et al. 2007

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Objective: To assess the selenium status of Southern Tasmanians. Design: Cross-sectional. Settings: One thousand and five hundred adults randomly selected from the electoral roll living in the Greater Hobart region of Southern Tasmania, Australia, were invited to participate. Subjects: The overall response rate was 22% (335/1500). Interventions: A venous blood sample was collected and a questionnaire administered (consisting of brief demographic details and health questions) to subjects who granted informed consent. A previously validated assay using magnetic sector ICP-MS was employed for plasma analysis. Results: Total plasma selenium levels for this sample population were normally distributed with a mean level of 110 mg/l (range 67-268 mg/l) indicating that the majority of the subjects were not selenium-depleted (71% with levels greater than 100 mg/l). Adjustment for differential age/gender response rates produced similar values. More women under 50 (42%) and men over 50 (32%) had selenium levels o100 mg/l with the potential for sub-optimal selenoprotein activity. Low education attainment was associated with low total selenium level (Po0.02). Conclusions: The majority of participants were not deficient in selenium. Given the narrow therapeutic window of supplementation, dietary advice to increase foods rich in selenium, particularly to higher risk groups, may be an effective means of increasing plasma selenium toward target levels.

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“…In addition, the statin users exhibited lower plasma selenium concentrations, while EVA volunteers without major chronic diseases or risk factors plasma selenium concentrations were found to be 0.99 ± 0.17 µmol/l (n=162) (data not reported). Various factors have been reported to modify plasma selenium [5,[24][25][26], sometimes with discrepant conclusions according to the studies. In this secondary analysis, only factors strongly related to dyslipidemia follow-up [23] have been taken into account.…”

Section: Discussionmentioning

confidence: 99%