Serum S100A8/A9 as a Potentially Sensitive Biomarker for Inflammatory Bowel Disease

Abstract

Background The clinical significance of human S100A8/A9 (h-S100A8/A9) in patients with inflammatory bowel disease (IBD) is poorly understood. Objective To clarify whether serum S100A8/A9 is a sensitive biomarker for IBD. Methods Serum specimens from outpatients with IBD (n = 101) and healthy volunteers (HVs) (n = 101) were used in this study. Enzyme-linked immunosorbent assays for h-S100A8/A9 and inflammatory cytokines were performed using these specimens. Further, correlation analysis was performed to investigate the significance of h-S100A8/A9 fluctuation in patients with IBD. Results The average of serum h-S100A8/A9 concentration in outpatients with IBD was significantly higher than that in HVs. The concentration of h-S100A8/A9 in patients with IBD was barely correlated with that of CRP and inflammatory cytokines. Despite that finding, the serum level of h-S100A8/A9 in patients with ulcerative colitis (UC) was correlated with the severity of IBD, compared with other inflammatory proteins. Conclusion Serum h-S100A8/A9 is superior to CRP as a sensitive biomarker for IBD.

Integrated Analysis of Multiple Microarray Studies to Identify Novel Gene Signatures in Ulcerative Colitis

“…Hence, CXCR2 is a potential target for UC treatment (Zhu et al, 2020). LCN2 (Østvik et al, 2013;Stallhofer et al, 2015;Buisson et al, 2018;Zollner et al, 2021) and S100A8 (Manolakis et al, 2011;Azramezani Kopi et al, 2019;Okada et al, 2019Okada et al, , 2020 are critical proinflammatory cytokines that have been reported in recent studies as potential molecular markers of UC in serum and stool samples. LCN2 and S100A8 also have antimicrobial effects and may be involved in the regulation of intestinal flora as antimicrobial peptides, which may be indirectly related to UC.…”

Suppressive effects of S100A8 and S100A9 on neutrophil apoptosis by cytokine release of human bronchial epithelial cells in asthma

“…International Publisher receptor for advanced glycation end products (RAGE). Therefore, S100A8 and S100A9 are essential causative stimulators in inflammatory diseases, and may be used as biomarkers and therapeutic targets [5][6][7].…”

Relating the transcriptome and microbiome by paired terminal ileal Crohn disease

“…In GOBP analysis, these gene families were involved in the development of cytokine-mediated signaling pathway, leukocyte migration, and myeloid leukocyte activation, and the results were similar to the KEGG analysis. Genes such as DOUX2 (Haberman et al, 2014), S100A8/A9 (Okada et al, 2019), CHI3L1 (Deutschmann et al, 2019), TNFRSF6B (Eriksson et al, 2008), and SLC6A14 (Luther et al, 2018) are also associated with CD. Although the colonic and terminal ileal tissues share a similar inflammatory status in CD, they may have different transcriptomes due to different genetic microenvironments and microbiomes.…”