Serum S100A12 levels are correlated with clinical severity in patients with dermatomyositis-associated interstitial lung disease

Abstract

Objective: S100A12 is an emerging inflammatory disease biomarker. Interstitial lung disease (ILD) is a common, severe complication of dermatomyositis (DM). This study was performed to investigate the association between S100A12 and disease activity and prognosis in patients with DM-associated ILD (i.e., DM-ILD). Methods: Serum S100A12 levels were measured using enzyme-linked immunosorbent assays in patients with stable DM-ILD, patients with acute exacerbation of DM-ILD (AE DM-ILD), and healthy controls (HCs). The relationships of serum S100A12 levels with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ferritin, high-resolution computed tomography (HRCT) scores, and pulmonary functions were evaluated by multiple unpaired t-tests and Pearson correlation. Results: Serum S100A12 levels were higher in patients with stable DM-ILD and those with AE DM-ILD than in HCs. Serum S100A12 levels in patients with stable DM-ILD and those with AE DM-ILD were positively correlated with CRP, ESR, and ferritin. S100A12 levels were positively correlated with HRCT scores in patients with stable DM-ILD and those with AE DM-ILD, while they were negatively correlated with predicted percentages of forced vital capacity and predicted percentages of carbon monoxide diffusing capacity in those patients. Conclusion: Our findings demonstrate the usefulness of serum S100A12 levels for assessing clinical severity and prognosis of DM-ILD.

Investigation of a Hypoxia-Immune-Related Microenvironment Gene Signature and Prediction Model for Idiopathic Pulmonary Fibrosis

“…The increase level of IL-1R2 has been reported to be associated with poor prognosis in lung cancer ( 34 , 35 ), and the increase level of IL-1 was associated with the development of chronic obstructive pulmonary disease (COPD) ( 36 , 37 ). Another risk gene S100A12 is a novel inflammatory disease biomarker in acute respiratory distress syndrome (ARDS) ( 38 ), interstitial lung disease (ILD) ( 39 ), and COPD ( 40 ). Moreover, C-C Motif Chemokine Ligand 8 (CCL8) is a kind of monocyte chemoattractant, regulating group 2 ILCs in lung inflammation ( 41 ).…”

Serum S100A12 levels: Possible association with skin sclerosis and interstitial lung disease in systemic sclerosis

“…Also, S100A12 is included in the top nine genes overexpressed in idiopathic interstitial pneumonia 40 . In patients with dermatomyositis‐associated ILD, serum S100A12 levels correlate positively with CRP, ESR, ferritin and high‐resolution computed tomography scores, and negatively with %VC and %DLco 16 . Given that a major source of S100A12 is neutrophils in the lung, S100A12 expression is believed to reflect neutrophil activation during lung inflammation.…”

“…40 In patients with dermatomyositis-associated ILD, serum S100A12 levels correlate positively with CRP, ESR, ferritin and high-resolution computed tomography scores, and negatively with %VC and %DLco. 16 Given that a major source of S100A12 is neutrophils in the lung, S100A12…”

“…Indeed, S100A9 induces proliferation and CCN2 production in dermal fibroblasts through the TLR4 signalling, 7 and circulating S100A8 levels are increased in dcSSc and serve as a possible biomarker for SSc‐associated ILD (SSc‐ILD) 8,11 . On the other hand, another S100A protein functioning as a ligand for TLR4 and RAGE, S100A12, 10 has not been investigated in SSc, though it plays a part in inflammatory skin diseases and systemic autoimmune diseases 12–16 …”

“…8,11 On the other hand, another S100A protein functioning as a ligand for TLR4 and RAGE, S100A12, 10 has not been investigated in SSc, though it plays a part in inflammatory skin diseases and systemic autoimmune diseases. [12][13][14][15][16] Over the last decade, epithelial cells have got recognized as a member of cells involved in SSc development. 3 For example, SSc keratinocytes persistently exhibit wound healing-associated phenotype along with IL-1α and CCN2 up-regulation, potentially contributing to fibroblast activation.…”