Serum Resistin Levels Are Associated with Adiposity and Insulin Sensitivity in Obese Hispanic Subjects

Nieva-Vazquez, Adriana; Pérez-Fuentes, Ricardo; Torres‐Rasgado, Enrique; López‐López, José; Romero, José R.

doi:10.1089/met.2013.0118

Cited by 47 publications

(40 citation statements)

References 41 publications

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“…Obese phenotype has been associated with a reduction in the anti-inflammatory and a boost in the pro-inflammatory adipokines. Our previous reports suggest interleukin 1β (IL1β) 22 , resistin 23 and TNFα 24 to play an important role in the development of obesity, islet dysfunction and decreased insulin secretion. On the contrary, adiponectin 2 , omentin-1 25 , melatonin 26 and vaspin 27 are known to enhance insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

Palit

Patel

Jadeja

et al. 2020

Sci Rep

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Adiponectin is a prime determinant of the status of insulin resistance. Association studies between adiponectin (ADIPOQ) gene single nucleotide polymorphisms (Snps) and metabolic diseases have been reported earlier. However, results are ambiguous due to apparent contradictions. Hence, we investigated (1) the association between ADIPOQ Snps: −11377C/G, +10211T/G, +45T/G and +276G/T for the risk towards type 2 diabetes (T2D) and, (2) genotype-phenotype association of these SNPs with various biochemical parameters in two cohorts. Genomic DNA of diabetic patients and controls from Gujarat and, Jammu and Kashmir (J&K) were genotyped using PCR-RFLP, TaqMan assay and MassArray. transcript levels of ADIPOQ were assessed in visceral adipose tissue samples, and plasma adiponectin levels were estimated by qPCR and ELISA respectively. Results suggest: (i) reduced HMW adiponectin/ total adiponectin ratio in Gujarat patients and its association with +10211T/G and +276G/T, and reduced ADIPOQ transcript levels in T2D, (ii) association of the above SNPs with increased FBG, BMI, TG, TC in Gujarat patients and (iii) increased GGTG haplotype in obese patients of Gujarat population and, (iv) association of −11377C/G with T2D in J&K population. Reduced HMW adiponectin, in the backdrop of obesity and ADIPOQ genetic variants might alter metabolic profile posing risk towards T2D.Metabolic Syndrome (MS) is the new wave of diseases that has hit the human population in the last few decadesthe Metabolic Syndrome Era. It has become pandemic and with obesity and type 2 diabetes (T2D) clubbed under the MS umbrella, millions of people around the globe have come under its grip. Though obesity and T2D are ubiquitous, there exists a pattern of prevalence based on ethnicity. A recent report has identified demographic transitions, nutrition and lifestyle in the backdrop of genetic predisposition as the chief factors responsible for the rising trend of obesity associated amongst South Asians 1 . Over accumulation of visceral adipose tissue (AT) has been identified as one of the major driving factors towards T2D. Adipose tissue is an important regulator of metabolic homeostasis by virtue of the adipokines (pro-inflammatory and anti-inflammatory) that it secretes. In obese conditions, the fine-tuned balance between the pro-and anti-inflammatory adipokines gets altered leading to various metabolic disorders 2 . These bioactive peptides act locally and distally to calibrate and fine tune various metabolic pathways. Adiponectin is one such calibrator which is abundantly expressed in white adipose tissue 3 . It circulates in three polymorphic forms, low molecular weight (LMW), moderate molecular weight (MMW) and high molecular weight (HMW). Interestingly, the ratio of plasma HMW adiponectin to total adiponectin is more strongly correlated with plasma glucose levels than any of the forms alone 4 . Adiponectin gene (ADIPOQ/ APM1/GBP28) locus, 3q27, has been strongly associated with a variety of metabolic disorders like-impaired glucose tolerance, obesity, dys...

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Section: Discussionmentioning

confidence: 99%

A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

Palit

Patel

Jadeja

et al. 2020

Sci Rep

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“…Diet‐induced obesity impairs NPY/AGRP neuronal responsiveness to ghrelin (Briggs, Enriori, Lemus, Cowley, & Andrews, ). Higher resistin levels are associated with higher adiposity and lower insulin sensitivity (Nieva‐Vazquez, Pérez‐Fuentes, Torres‐Rasgado, López‐López, & Romero, ). The current study has demonstrated a decrease in the protein IGF‐1 levels (Table ).…”

Section: Discussionmentioning

confidence: 99%

Dietary fatty acids from pomegranate seeds (Punica granatum) inhibit adipogenesis and impact the expression of the obesity-associated mRNA transcripts in human adipose-derived mesenchymal stem cells

2018

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Obesity is a metabolic disorder that manifests into various forms. Recent studies have indicated that the pomegranate (Punica granatum) seed oil (PSO) has many biologically active components that help in controlling diet‐induced obesity and insulin resistance. However, its impact on the adipogenic differentiation of human adipose‐derived mesenchymal stem cells (HADMSC) remains unclear. Here we have attempted to study the anti‐obesity potential of SHAMstat3pg, a fatty acid composite extracted from PSO. It is composed of three dietary fatty acids: punicic acid [(9Z,11E,13Z)‐9,11,13‐Octadecatrienoic acid], oleic acid [Cis‐9‐Octadecenoic acid], and linoleic acid [(9Z,12Z)‐octadeca‐9,12‐dienoic acid]. In this study, we discuss the impact of the fatty acids on adipogenesis, inflammation, glucose uptake, and mitochondrial ATP production. The impact of SHAMstat3pg on the expression of various obesity‐associated protein and mRNA transcripts in HADMSC was also analyzed. The results indicate that exposure to 10 µg/ml of SHAMstat3pg (24 hr) inhibited adipogenesis of HADMSC, ameliorated inflammation, attenuated ATP production, and glucose uptake. Also, the extract favorably regulated the mRNA expression of the studied obesity‐associated gene transcripts. Practical applications SHAMstat3pg has the potential to serve as a multi‐targeted therapy for the management of obesity. This study demonstrated that the dietary fatty acids inhibited the differentiation of preadipocytes to adipocytes. SHAMstat3pg has also shown to have a favorable impact on the expression of the obesity‐linked proteins and genes in HADMSC that are associated with adipogenesis, inflammation, satiety, energy intake/expenditure (central and peripheral signaling molecules). The study gives an overview of the vast number of genes impacted by the treatment with SHAMstat3pg paving the way for future studies to demonstrate the exact mode of action of how dietary fatty acids can help manage obesity, insulin resistance, and type 2 diabetes.

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“…On the other hand, PRL reduction were stated in the two survey; one of them evaluated the effects of 12-months physical activity in patients with DMT2 [50] and the other assessed the effects of 16 weeks of resistance training in older postmenopausal women [24]. Notably, increased resistin levels has been reported in study on obese mice [51] and also it should be noted that; resistin levels are described higher in men than in women [52].…”

Section: Discussionmentioning

confidence: 99%

Blood Levels of Resistin, Glycemic Indices and Lipid Profile in Women with Type 2 Diabetes

Tofighi¹,

Samadian²,

Mahdizadeh³

2016

J Diabetes Metab

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We aimed to compare the changes in PRL with glycemic indices and lipid profile and also to investigate the relationship of insulin resistance (IR) with PRL in obese postmenopausal women with diabetes mellitus type 2 (DMT2) following 12-week aerobic, resistance and combined exercises, while our inclusion and exclusion criteria and also design exercise protocol differ from other studies in this field. In a quasi-experimental study for 12 weeks, 40 women with DMT2 were randomly selected by availability and purposive sampling and divided into four equal groups of aerobic training, resistance, combined and control group. Aerobic group accomplished aerobic exercise (AEX), 3x/week, for 20-50 minutes at 50-70% of maximum heart rate. Resistance group received resistance exercise (REX), 3x/week in three sets of 10 repetitions with 40-60% of one repetition maximum. The program in combined group consisted of a combination of AEX and REX with the same intensity and duration (included 2 sessions of AEX and 1 session of REX per week. But fortnightly, the numbers of these sessions were changed with each other). The control group was without exercise program. Blood samples for determination of PRL, lipid profile and glycemic indices in pre-and post-tests were collected. HOMA-IR equation was used to calculate insulin resistance. Statistical analysis was performed using SPSS software version 21. According to our finding; the effect of AEX and combined exercises was more than control group on the increasing PRL. The result of AEX in weight loss was more than REX however, the outcome of REX in insulin and IR reducing; also TC declining was more than the AEX. While the effect of combined group in decreasing body fat percent was more than AEX group, but the consequence of AEX was more than the combined group for reducing waist-to-hip ratio (WHR). The effect of the combined group in reducing low density lipoprotein (LDL) was more than the REX group. Also, weight, fasting blood glucose, insulin, triglycerides, LDL, glycosylated hemoglobin A1c and WHR were the predictors of IR. It seems that, during the study period, all three types of exercises through different mechanisms had valuable effects on glycemic indices and lipid profile in DMT2 patients. Also due to the increase in PRL and non-significant correlation with IR; it is doubtful that resistin be as a factor in the incidence of DMT2.

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Serum Resistin Levels Are Associated with Adiposity and Insulin Sensitivity in Obese Hispanic Subjects

Cited by 47 publications

References 41 publications

A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

A genetic analysis identifies a haplotype at adiponectin locus: Association with obesity and type 2 diabetes

Dietary fatty acids from pomegranate seeds (Punica granatum) inhibit adipogenesis and impact the expression of the obesity-associated mRNA transcripts in human adipose-derived mesenchymal stem cells

Blood Levels of Resistin, Glycemic Indices and Lipid Profile in Women with Type 2 Diabetes

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