Serum proteomic signature of Trypanosoma evansi –infected mice for identification of potential biomarkers

Calomeno, Nathália Anderson; Moreira, Renato Simões; Fernandes, Leonardo Antônio; Batista, Franciane; Marques, Júlia; Wagner, Glauber; Miletti, Luiz Cláudio

doi:10.1016/j.vetpar.2021.109342

Cited by 3 publications

(1 citation statement)

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“…T. evansi infects wild animals and livestock, causing animal Trypanosoma disease, also known as surra. The disease is widely distributed in tropical and subtropical areas ( 35 ). In recent years, T. evansi has also been reported to infect humans, suggesting that this pathogen has the potential to become a zoonotic parasitic pathogen ( 36 ).…”

Section: Phylum Sarcomastigophora Class Zoomastigophoreamentioning

confidence: 99%

The State of Art of Extracellular Traps in Protozoan Infections (Review)

2021

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Protozoan parasite infection causes severe diseases in humans and animals, leading to tremendous economic and medical pressure. Natural immunity is the first line of defence against parasitic infection. Currently, the role of natural host immunity in combatting parasitic infection is unclear, so further research on natural host immunity against parasites will provide a theoretical basis for the prevention and treatment of related parasitic diseases. Extracellular traps (ETs) are an important natural mechanism of immunity involving resistance to pathogens. When immune cells such as neutrophils and macrophages are stimulated by external pathogens, they release a fibrous network structure, consisting mainly of DNA and protein, that can capture and kill a variety of extracellular pathogenic microorganisms. In this review, we discuss the relevant recently reported data on ET formation induced by protozoan parasite infection, including the molecular mechanisms involved, and discuss the role of ETs in the occurrence and development of parasitic diseases.

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Section: Phylum Sarcomastigophora Class Zoomastigophoreamentioning

confidence: 99%