Serum proteins in acutely psychotic patients

Bock, Elisabeth; Weeke, B.; Rafaelsen, Ole J.

doi:10.1016/0022-3956(71)90003-3

Cited by 43 publications

(15 citation statements)

References 45 publications

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“…Our study extends work with plasma AAG levels measured in schizophrenic patients for an additional 4 weeks. Plasma AAG levels were reported to be elevated in depressed patients [2][3][4], Tricyclic antidepressants are also significantly bound to AAG plasma proteins [5][6][7][8][9], A significant correlation was found between the inverse free fraction amount (1/F) and plasma AAG levels (r = 0.94, p < 0.001). However, plasma AAG levels did not correlate with clinical improvement.…”

Section: Plasma Aag and Haloperidol Concentrations In Schizophrenic Pmentioning

confidence: 78%

“…The plasma AAG can extensively vary dependent upon disease state, the use of medications and pregnancy. In psychiatric illnesses, AAG plasma levels were reported to be elevated in depressed patients and schizophrenics [2][3][4], Prior studies have measured plasma AAG concentra tions in schizophrenic patients treated with haloperidol (HL) [10]. AAG measurements were obtained prior to HL treatment and 2 weeks afterwards.…”

Section: Introductionmentioning

confidence: 99%

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Plasma Alpha-One Acid Glycoprotein and Haloperidol Concentrations in Schizophrenic Patients

et al. 1997

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Thirty six schizophrenic patients were randomly assigned to placebo or haloperidol treatment for 6 weeks. Blood samples to measure plasma alpha-one acid glycoprotein (AAG), haloperidol and reduced haloperidol concentrations were obtained at baseline and weeks 2, 4, and 6. Blood samples were obtained 10-12 h after the evening dose and prior to the morning dose. Haloperidol and reduced haloperidol was assayed by HPLC with electrochemical detection. Plasma AAG levels were assayed by radial immunodiffusion. Patients were clinically assessed by the Brief Psychiatric Rating Scale (BPRS) and Abnormal Involuntary Movement Scale at baseline and weeks 2, 4, and 6. BPRS scores did not significantly decrease during placebo treatment, although a slight drop in plasma AAG levels was found. Haloperidol produced a significant decrease in BPRS scores and plasma AAG levels. Mean plasma haloperidol levels were 12.9 ± 14.7 ng/ml at week 6. Significant correlations between decreasing BPRS scores and plasma AAG levels were not found with only a strong trend at week 2 (r = 0.445, p = 0.073). The role of AAG and psychotropic drug disposition in psychiatric patients requires further evaluation.

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Section: Plasma Aag and Haloperidol Concentrations In Schizophrenic Pmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Plasma Alpha-One Acid Glycoprotein and Haloperidol Concentrations in Schizophrenic Patients

et al. 1997

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“…Del Vecchio et al (1975) demonstrated that chronic schizophren ics with a family history of schizophrenia had a significantly higher serum IgA level than chronic schizophrenics without a familial clustering of the disease. However, Bock et al (1971) found low serum IgM levels in schizophrenics and a low serum IgA level in patients diagnosed as 'borderline psychotic' compared to healthy con trols. Hendrie et al (1972) could not confirm the results of abnormal IgG, IgA and IgM levels in schizophrenics, whereas Strahilevitz et al (1976) found elevated mean IgA values in schizo phrenic women compared with control women, and in schizophrenic blacks compared with schizophrenic whites or black controls.…”

Section: Discussionmentioning

confidence: 97%

An Immunological Basis of Schizophrenia and Affective Disorders?

et al. 1980

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In 48 patients with schizophrenia and 32 patients with affective disorders, different immune parameters were tested. Compared to blood-donors, IgG and IgM serum concentrations were increased in both the schizophrenic and affective disorders. However, these abnormalities did not differ from hospital control populations. The patients failed to show an association of antibodies considered to be characteristic of autoimmune diseases. In addition, no increased incidence of circulating immune complexes was detected. The only substantial serologic abnormality found was an elevation of C4 levels in patients with bipolar psychosis.

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“…Human serum albumin (HSA) and α 1 -acid glycoprotein (AAG) are well known as important drug binding proteins in plasma. HSA is the most abundant protein (3.8-5.1 g/dL), and a normal AAG level is 50-100 mg/dL (Bock et al, 1971;Nemeroff et al, 1990;Kehoe et al, 1991). They can vary extensively, depending on disease state.…”

Section: Haloperidolmentioning

confidence: 99%

Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone‐type neuroleptics by high performance liquid chromatography with dual ultraviolet detection

Higashi

Kitahara

Fujii

2005

Biomedical Chromatography

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We investigated simultaneous determination of haloperidol (HAL), its three metabolites [reduced HAL (R-HAL), 3-(4-fluorobenzoyl)propionic acid (FBPA) and 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP)] and two related compounds [spiperone (SPI) and droperidol (DRO)] in phosphate-buffered saline using high-performance liquid chromatography (HPLC) coupled with dual ultraviolet detection (220 and 250 nm). Retention times of HAL, R-HAL, FBPA, CPHP, SPI and DRO were 16.8, 11.8, 10.2, 4.1, 12.6 and 8.3 min, respectively. Their lower limits of detection were 7.5, 14, 4.5, 12, 10 and 20 ng/mL in the same order. The coefficients of variation for their intra- and inter-day assays were less than 7.8 and 9.4%, respectively. Of the other centrally acting drugs, only amoxapine interfered with the peak of DRO. Using our procedure, the binding study of tested compounds to synthetic melanin, human serum albumin and alpha1-acid glycoprotein was performed by determining the unbound concentration to total concentration ratio. These results indicated that simultaneous assay of HAL, R-HAL, FBPA, CPHP, SPI and DRO in phosphate-buffered saline by HPLC equipped with dual ultraviolet detection is simple, sensitive and reproducible. Also, our assay system can be applied to the binding study of these compounds to synthetic melanin, human serum albumin and alpha1-acid glycoprotein.

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Serum proteins in acutely psychotic patients

Cited by 43 publications

References 45 publications

Plasma Alpha-One Acid Glycoprotein and Haloperidol Concentrations in Schizophrenic Patients

Plasma Alpha-One Acid Glycoprotein and Haloperidol Concentrations in Schizophrenic Patients

An Immunological Basis of Schizophrenia and Affective Disorders?

Simultaneous analysis of haloperidol, its three metabolites and two other butyrophenone‐type neuroleptics by high performance liquid chromatography with dual ultraviolet detection

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