Serum Proteins and Secretory Component in Human Carious Dentin

Okamura, Kazuki; Tsubakimoto, Kumio; Uobe, Kenichi; Nishida, Ken; Tsutsui, Masahiro

doi:10.1177/00220345790580031701

Cited by 17 publications

(9 citation statements)

References 16 publications

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“…The presence of endoplas mic reticulum as well as large multivesicular bodies was never noted in normal condi tions. It is possible that these different vac uoles and bodies assume lysosomal func tions or are able to transport some serum proteins from the pulp to the process as sug gested by Okamura et al [1979]. Further investigations will be necessary to investi gate the precise significance of these ele ments.…”

Section: Discussionmentioning

confidence: 98%

Ultrastructure of the Human Odontoblast Process and Its Mineralisation during Dental Caries

Frank

Voegel

1980

Caries Res

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A transmission electron microscope and electron diffraction study of the inner layer of human dentine carious lesions adjacent to the transparent zone has shown no sign of degeneration of the odontoblast processes which were rich in microfilaments, microtubules and large vacuoles. Intratubular calcification occurred either by an initial mineralisation of the periodontoblastic space followed by the calcification of the odontoblast process or by an initial intracytoplasmic calcification followed by a secondary periodontoblastic mineralisation. Initial inorganic crystalline deposits in the periodontoblastic space consisted of whitlockite with the presence of hydroxyapatite at later stages.

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Section: Discussionmentioning

confidence: 98%

Ultrastructure of the Human Odontoblast Process and Its Mineralisation during Dental Caries

Frank

Voegel

1980

Caries Res

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“…The IgG concentration in dentin appears to be approximately 15 to 20% of that in albumin. In or under carious lesions, at least part of the IgGs in dentinal tubules may be derived from saliva . Pulp‐derived IgG has been found to be present in the dentin of intact teeth, while other Ig classes (IgA1 and ‐2, IgM) are present either in very minor amounts or only under carious lesions .…”

Section: Dentin Serum Proteinsmentioning

confidence: 99%

A review of the nature, role, and function of dentin non‐collagenous proteins. Part II: enzymes, serum proteins, and growth factors

Mazzoni¹,

Breschi²,

Carrilho³

et al. 2009

Endodontic Topics

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Part I was an overview of the role and function of proteoglycans and glycoproteins in the pulpo–dentin complex; part II will focus on enzymes, serum proteins, and growth factors. This review will discuss current knowledge regarding matrix metalloproteinases (MMPs), cathepsins, serum proteins, and growth factors in dentin and the related dentin–pulp complex in an attempt to better understand their nature, role, and function in the dentin extracellular matrix (ECM) environment. Dentin formation in physiological and pathological conditions has been widely studied. However, the regulation and involvement of non‐collageneous enzymes, serum proteins, and growth factors are still not completely elucidated. MMPs, a family of 23 endopeptidases in humans, are collectively capable of degrading virtually all ECM components, and their specific tissue inhibitors (TIMPs: tissue inhibitors of matrix metalloproteinases) participate in organo‐ and morphogenesis, physiological tissue turnover, and pathological tissue destruction. Similarly, the lysosomal cysteine proteinases (cathepsins) are capable of degrading ECM proteins such as collagen, laminin, fibronectin, and proteoglycans. These enzymes are implicated in a variety of pathological conditions, especially in diseases involving tissue re‐modeling states. Dentin also contains serum‐derived proteins (such as albumin, immunoglobulins, and transferrin), and a variety of growth factors in the mineralized ECM are available for release during demineralization or other injury. A detailed description of the components of the above‐mentioned dentin non‐collageneous proteins will be summarized in this literature review.

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“…By the use of the direct pcroxidasc-labclled antibody method, Okamura ct al. (1) observed immunoglobulin (Ig) (i and IgA in both shallow and deep lesions of carious human dentin. but no secretory component (SC) was found in the deep lesions.…”

mentioning

confidence: 97%

“…It is probable that the method employed in the first study was not sensitive enough to vi-suali^'c SC in deep lesions (1). The later study (2) used a method of at least one hundred times greater sensitivity (5), for the visualization of small quantities of scrum SC.…”

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confidence: 99%

Histological study on the origin of dentinal immunoglobulins and the change in their localization during caries

Okamura

1985

J Oral Pathology Medicine

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Al the incipient stage of the caries process prior to destruction, immunoglohullns were first localized in the odonlohlasl layer in spile of ahsencc of plasma cells in the pulp, and secondly located in the dcntiniil tuhules of the pulpal side of dentin. When the tooth hccamc involved, caries immunoglohulins were localized under the lesion Bovine serum alhumin, which was administered on loolh surfaces, was not observed in the non decayed area ot dentin. When injected inlo blood vessels, the protein was found in both decayed and unaffected dentin It is suggested that, at the incipient stapc of the caries process, denlinal nnmunoglobulins come from the pulp, although the possitiilily of salivary origin at a later stage is not excluded; and that inimunoglohulin localization changes during the caries process.

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Serum Proteins and Secretory Component in Human Carious Dentin

Cited by 17 publications

References 16 publications

Ultrastructure of the Human Odontoblast Process and Its Mineralisation during Dental Caries

Ultrastructure of the Human Odontoblast Process and Its Mineralisation during Dental Caries

A review of the nature, role, and function of dentin non‐collagenous proteins. Part II: enzymes, serum proteins, and growth factors

Histological study on the origin of dentinal immunoglobulins and the change in their localization during caries

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