Serum protein electrophoresis in 155 cats

Taylor, Samantha; Tappin, Simon; Dodkin, SJ; Papasouliotis, Kostas; Casamian‐Sorrosal, Domingo; Tasker, Séverine

doi:10.1016/j.jfms.2010.03.018

Cited by 57 publications

(63 citation statements)

References 24 publications

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“…Seeing that the gamma region is composed predominantly of antibodies of the IgG type, higher concentrations of γ-globulins obtained in calves with chronic respiratory diseases may reflect the response of the organism to inflammation. Taylor et al (2010) indicated that the increases in globulin fractions, particularly of the γ-globulins are associated with chronic antigenic stimulation. Stockholm and Scott (2008) stated that decreased albumin and an increase in globulin concentrations is the most common pattern in animals subjected to inflammatory diseases, which reflect the compensatory reduction in albumin concentrations to maintain oncotic pressure and viscosity.…”

Section: Discussionmentioning

confidence: 99%

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

Tóthová¹,

Nagy²,

Kováč³

2013

ACTA VET-BEOGRAD

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The aim of this study was to evaluate the serum proteins electrophoretic pattern and the concentrations of acute phase proteins in calves with chronic bronchopneumonia. Twenty-eight calves with clinical symptoms of disease were included into the evaluation. Blood serum was analyzed for total protein concentrations (TP), total and relative values of serum protein fractions, albumin/globulin ratio (A/G) and the concentrations of selected acute phase proteins -haptoglobin (Hp), serum amyloid A (SAA), and fibrinogen (Fbg). The results recorded in sick animals were compared with those in 36 clinically healthy calves as control group. In calves suffering from chronic bronchopneumonia we found significantly higher total serum protein concentrations than in healthy calves (p<0.001). In sick calves a marked shift in the concentrations of most of the protein fractions was observed, with significantly higher mean total values of α 1 -(p<0.001), β 1 -(p<0.01), β 2 -(p<0.001), and γ-globulins (p<0.001) and relative mean values of α 1 -(p<0.01), β 2 -(p<0.01), and γ-globulins (p<0.001). On the other hand, the concentrations of albumin and A/G ratios were in calves with respiratory diseases significantly lower than those measured in healthy ones (p<0.001). The mean concentrations of α 2 -globulins did not differ significantly between the two groups of animals. In the affected calves significantly higher mean values of Hp, SAA, as well as Fbg (p<0.001) were described. The presented results suggest a marked effect of chronic bronchopneumonia in calves on most of the evaluated protein profiles and acute phase protein variables with a marked shift in the albumin and globulin concentrations.

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Section: Discussionmentioning

confidence: 99%

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

Tóthová¹,

Nagy²,

Kováč³

2013

ACTA VET-BEOGRAD

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“…Diagnosis of FIP is complicated and the cat's clinical history together with results from several analyses including serology, PCR and postmortem analyses are often required before a definite diagnosis can be reached (Shelly et al, 1988;Hartmann et al, 2003;Addie et al, 2004Addie et al, , 2009Pratelli, 2008;Sharif et al, 2010;Taylor et al, 2010). Hematological and biochemical changes in FIP cases are not very specific, but ascites, increase in serum protein level, increase in bilirubin, decrease in hematocrit and decrease in A:G ratio are prominent (Addie et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

A retrospective clinical and epidemiological study on feline coronavirus (FCoV) in cats in Istanbul, Turkey

Tekelioğlu¹,

Berriatua

Turan

et al. 2015

Preventive Veterinary Medicine

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The presence of antibodies to feline coronavirus (FCoV) and feline immunodeficiency virus (FIV), together with feline leukemia virus (FeLV) antigen was investigated in 169 ill household and stray cats attending a veterinary surgery in Istanbul in 2009-14. The estimated FCoV and FIV seroprevalence (95% confidence intervals) were 37% (30-45%) and 11% (6-16%), respectively and FeLV prevalence was 1% (0-3%). FCoV seroprevalence increased until 2 years of age, was highest in 2014 and among household cats living with other cats and with outdoor access, and was lower in FIV seropositive compared to seronegative cats. Symptoms typically associated with wet feline infectious peritonitis (FIP) including ascites, abdominal distention or pleural effusion, coupled in many cases with non-antibiotic responsive fever, were observed in 19% (32/169) of cats, and 75% (24/32) of these cats were FCoV seropositive. FCoV seropositivity was also associated with a high white blood cell count, high plasma globulin, low plasma albumin and low blood urea nitrogen. The percentage of FCoV seropositive and seronegative cats that died in spite of supportive veterinary treatment was 33% (21/63) and 12% (13/106), respectively. These results indicate that FCoV is widespread and has a severe clinical impact in cats from Istanbul. Moreover, the incidence of FCoV infections could be rising, and in the absence of effective vaccination cat owners need to be made aware of ways to minimize the spread of this virus.

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“…20 While the qualitative analysis of immunoglobulins (IgA, IgG, IgM, IgD) and their κ and λ subunits by immunofixation of serum in agar gel was not performed, the presence of a narrow spike in the γ region on SPE is suggestive of monoclonal immunoglobulin production, particularly of IgG. 11 Thus, we suspect that immunoglobulin secretion by B-cell TILs generated the observed paraneoplastic monoclonal gammopathy.…”

Section: Discussionmentioning

confidence: 99%

Primary bronchial carcinoma associated with bone marrow metastasis and paraneoplastic monoclonal gammopathy in a cat

Cervone¹,

Beurlet²

2016

Journal of Feline Medicine and Surgery Open Reports

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Case summaryHerein we describe an unusual metastatic pattern and paraneoplastic manifestation of a bronchial carcinoma in a cat. An 8 year-old cat presented with a diminished appetite, dysphagia, weight loss, lethargy and coughing. Thoracic radiographs revealed a lung mass. Bronchial carcinoma was diagnosed on the basis of histology and was associated with a lymphoplasmocytic infiltration of the fibrovascular stroma. Biochemistry showed hyperproteinaemia. Serum protein electrophoresis showed a narrow spike in the gamma region. Bone marrow cytology revealed an infiltrate with numerous clustered epithelial cells. The cat was euthanased 2 months later because of anorexia and poor general condition.Relevance and novel informationTo the best of our knowledge, this is the first clinical description of primary bronchial carcinoma associated with bone marrow metastases and paraneoplastic monoclonal gammopathy in a cat.

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Serum protein electrophoresis in 155 cats

Cited by 57 publications

References 24 publications

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

The serum protein electrophoretic pattern and acute phase proteins concentrations in calves with chronic respiratory diseases

A retrospective clinical and epidemiological study on feline coronavirus (FCoV) in cats in Istanbul, Turkey

Primary bronchial carcinoma associated with bone marrow metastasis and paraneoplastic monoclonal gammopathy in a cat

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