Serum Prostatic Specific-Antigen Concentrations in Acute Myocardial Infarction

Crook, Martin; Preston, K. J.; Lancaster, Ian

doi:10.1093/clinchem/43.9.1670

Cited by 19 publications

(6 citation statements)

References 2 publications

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“…The rise of tPSA in our four patients did not change the statistical result. In our study when all of our patients' findings were statistically examined we found similar results as did Crook et al (1997). Crook et al (1997) measured tPSA levels 1, 2 and 3 days after AMI and reported tPSA levels significantly lower on the second day than on the first and third days.…”

Section: Discussionsupporting

confidence: 82%

“…In our study when all of our patients' findings were statistically examined we found similar results as did Crook et al (1997). Crook et al (1997) measured tPSA levels 1, 2 and 3 days after AMI and reported tPSA levels significantly lower on the second day than on the first and third days. In that study as well as in our study, the maximum reduction was on day 2 and a significant increase was detected on day 3.…”

Section: Discussionsupporting

confidence: 82%

“…However, they did not determine fPSA levels in these patients nor do they state the number of their patients. They indicated that their results could be associated with factors such as thrombolytic therapy, reduced physical activity and acute phase response (Crook et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

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Prostate specific antigen levels after acute myocardial infarction.

Açıkgöz

Can²,

Doğan³

et al. 2011

Acta Biochim Pol

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Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/ Albumin ratio according to days were not found significant. In only four patients we found increased levels of tPSA and increased fPSA levels in three of them. These patients displayed severe problems such as renal failure, cardiac failure, ventricular aneurysm and cerebral ischemia due to cardiac arrest. The lower tPSA levels on day 2 suggest that tPSA can be eliminated rapidly from the circulation on days 1 and 2, probably through the formation of complexes of tPSA with acute phase proteins.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 82%

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Prostate specific antigen levels after acute myocardial infarction.

Açıkgöz

Can²,

Doğan³

et al. 2011

Acta Biochim Pol

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“…Recently, attention has been focused on the association between PSA levels and the cardiovascular system [21]. PSA variation has been associated with coronary lesions and occurrence of major adverse cardiac events, which intrigued new possible scenarios considering the role of PSA [4]. On the other hand, arterial stiffness is an independent predictor of cardiovascular risk in the general population, in subjects with risk factors, including hypertension, and in various disease states [22–24].…”

Section: Discussionmentioning

confidence: 99%

“…Prostate‐specific antigen (PSA) is a glycoprotein produced primarily from the epithelial cells of the prostate gland and its regulation is under the control of androgens and progestins. The physiological function of PSA is not yet entirely clarified; while it is possibly related to the activity of kallikreins [1–3], it has also other potential functions, such as inhibition of cell growth, procession of anticarcinogenic/antiangiogenic properties, and induction of apoptosis [4]. Although its clinical utility is confined to the detection of prostatic hyperplasia and cancer [5], at lower concentrations it has been detected in many tissues, including the female breast [4].…”

Section: Introductionmentioning

confidence: 99%

Prostate-Specific Antigen Levels are Associated with Arterial Stiffness in Essential Hypertensive Patients

Vyssoulis

Karpanou

Kyvelou

et al. 2012

The Journal of Sexual Medicine

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Introduction Prostate-specific antigen (PSA) has been recently related to cardiovascular system in a multifactorial way. Arterial stiffness is a independent predictor of cardiovascular events and is involved in the pathogenesis of hypertension. The aim of the present study was to investigate whether PSA values, are associated with arterial stiffness indices in patients with essential arterial hypertension. Methods The study comprised 150 consecutive male patients (mean age 60 years) with uncomplicated never-treated essential hypertension. All patients underwent a complete clinical and laboratory evaluation, including measurement of PSA levels. Aortic stiffness and arterial wave reflection assessment was made by using carotid-femoral (PWVc-f) pulse wave velocity and aortic augmentation index corrected for heart rate (AIx75). Patients with prostate cancer or benign prostate hyperplasia (PSA > 4 ng/mL) were excluded from the study. Results PSA was positively associated with waist-to-hip ratio (r = 0.235, P = 0.04), PWVc-f (r = 0.426, P < 0.001), AIx75 (r = 0.264, P = 0.001), and high sensitivity C-reactive protein (hsCRP; r = 0.376, P < 0.001). In categorization to PSA quartiles, patients in the higher quartile presented with higher waist-to hip ratio (P = 0.009), PWVc-f (P < 0.00001), AIx75 (P < 0.001) and hsCRP (P < 0.001) values. In multivariate analysis after adjustment for various confounders PSA remained a significant determinant of PWVc-f values (beta [SE] = 0.477 [0.13], R2 = 0.405, P < 0.001). Conclusion The present study points towards an association between PSA levels and aortic stiffness in untreated essential hypertensive males. Potential causal relationships between PSA and arterial stiffness remain to be further explored.

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