Serum prolidase enzyme activity and oxidative stress levels in patients with acute hemorrhagic stroke

Abstract

Findings from the study suggest an association between increased oxidative stress levels, decreased antioxidant levels and increased prolidase enzyme activity in patients with acute hemorrhagic stroke compared with controls. More studies are needed to elucidate mechanistic pathways on oxidative stress in patients with acute hemorrhagic stroke.

Oxidative Stress and Antioxidant Markers in Serum and Red Blood Cell of Patients with Ischemic and Hemorrhagic Stroke: A Case-Control Study

“…They found that TAC in the HS group decreased significantly more than the control group. They used the Erel method to measure TAC and found that a defective system of free radicals may increase intracerebral hemorrhagic oxidative damage (21). The difference in TAC measurement methods could be the reason for the inconsistent results between the current study and that of Genula at al.…”

Serum prolidase enzyme activity as a diagnostic marker for acute ischemic stroke

“…Prolidase activity has been shown to be significantly different in a variety of diseases that are thought to involve the pathogenesis of collagen biosynthesis [20]. In some clinical trials, increased SPA has been detected in a variety of diseases, such as chronic liver diseases, various tumor types (including breast and lung cancer), bronchial asthma, fetal intrauterine growth retardation and neural tube defects, bipolar disorder, thalassemia major, and erectile dysfunction [4,5,21,22].…”

“…Prolidase activity has been reported to be associated with inflammation in the fibrosis process and with oxidative stress in different diseases [6]. Inflammation and oxidative stress have important roles in the ischemic stroke pathogenesis [5,24]. Inflammation plays an important role during ischemic events and in the development of atherosclerosis.…”

“…ROS have an important role in hemorrhagic and ischemic brain injuries. Many cell types can be negatively affected by oxidative stress and contribute to vascular pathologies, especially stroke pathophysiology [5].…”

“…Collagen is the basis for the connective tissue structures involved in inflammation, wound healing, cell movement, trophoblast implantation, and fetal development [4]. Collagen types 1 and 3 fibers are important for the arterial wall strength [5]. Consequently, any vascular damage will affect the collagen cycle.…”