Comparison of tissue prolidase enzyme activity and serum oxidative stress level between pregnant women with placental abruption and those with a healthy pregnancy

Incebiyik, Adnan; Vural, Mehmet; Camuzcuoğlu, Aysun; Camuzcuoğlu, Hakan; Hilali, Neşe Gül; Taşkın, Abdullah; Aydin, Halef; Aksoy, Nurten

doi:10.1007/s00404-014-3481-4

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…Thrombophlebitis, pulmonary embolism, myocardial infarction, and stroke are all potential outcomes of this condition (9,10). Other T variables that may play a significant role in the development of varicose veins include advanced age, limited mobility, smoking, therapy with estrogen, diabetes mellitus, and hypertension (11,12). In this study we aimed at how the enzyme prolidase contributes to the development of varicose veins in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Effect of prolidase on the development of varicose veins in pregnant women

Al-Bahrani¹

2023

Biomedicine

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Introduction and Aim: Varicose veins are more common during pregnancy and, if left untreated, can cause venous insufficiency and edema in the legs. Women have venous insufficiency both before and after pregnancy. According to research, the cytosolic metalloproteinase prolidase regulates the breakdown of collagen and other proteins in the extracellular matrix. Prolidase deficiency, which impairs the enzyme's normal function, has severe clinical manifestations. The objective of this study is to discover how the enzyme prolidase influences the development of varicose veins in pregnant women. Materials and Methods: This study included approximately 70 women aged 25-45 years who were pregnant in their third trimester. The participants were assigned to two groups based on diagnosis of having varicose veins (n=40) and those without (n=30). Quantitative measurements of serum progesterone and prolidase concentrations were made. Data collected was subjected to statistical analysis. Results: Varicose veins were prevalent in 57.14% of the pregnant women, the severity of which increased with age. The mean blood concentrations of progesterone and prolidase levels were higher in pregnant women with varicose veins in comparison to controls. Conclusion: Chronic venous insufficiency and mild varicose veins are more common in pregnant women aged 40 years and above. An increased level of progesterone and prolidase enzyme in serum was seen to be associated with chronic varicose insufficiency in pregnant women.

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Section: Introductionmentioning

confidence: 99%

Effect of prolidase on the development of varicose veins in pregnant women

Al-Bahrani¹

2023

Biomedicine

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Vitamin E supplementation in pregnancy

Rumbold

Ota

Hori

et al. 2015

Cochrane Database of Systematic Reviews

103

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The data do not support routine vitamin E supplementation in combination with other supplements for the prevention of stillbirth, neonatal death, preterm birth, pre-eclampsia, preterm or term PROM or poor fetal growth. Further research is required to elucidate the possible role of vitamin E in the prevention of placental abruption. There was no convincing evidence that vitamin E supplementation in combination with other supplements results in other important benefits or harms.

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Vitamin C supplementation in pregnancy

Rumbold

Ota

Nagata

et al. 2015

Cochrane Database of Systematic Reviews

113

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The data do not support routine vitamin C supplementation alone or in combination with other supplements for the prevention of fetal or neonatal death, poor fetal growth, preterm birth or pre-eclampsia. Further research is required to elucidate the possible role of vitamin C in the prevention of placental abruption and prelabour rupture of membranes. There was no convincing evidence that vitamin C supplementation alone or in combination with other supplements results in other important benefits or harms.

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Comparison of tissue prolidase enzyme activity and serum oxidative stress level between pregnant women with placental abruption and those with a healthy pregnancy

Abstract: Our results indicated that elevated tissue PEA and serum oxidative stress levels are closely related to placental abruption. Thus, we think that increased collagen turnover may have a significant role in the aetiopathogenesis of placental abruption.

Cited by 7 publications

References 26 publications

Effect of prolidase on the development of varicose veins in pregnant women

Effect of prolidase on the development of varicose veins in pregnant women

Vitamin E supplementation in pregnancy

Vitamin C supplementation in pregnancy

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