Serum placental growth factor in the three trimesters of pregnancy: effects of maternal characteristics and medical history

Tsiakkas, Andreas; Duvdevani, N.; Wright, Alan; Wright, David; Nicolaides, Kypros H.

doi:10.1002/uog.14811

Cited by 135 publications

(166 citation statements)

References 24 publications

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“…A limitation of this study is the relatively small number of cases, but we find these numbers to be comparable to previous casecontrol studies investigating serum cytokines in hypertensive pregnancy disorders, 33,34,53 and our study includes a larger control group. Because our medium-to high-risk cohort predominantly included women developing late-onset gestational hypertension or preeclampsia, the findings presented here should be followed-up in a general pregnant population with larger groups, including early-and late-onset disease.…”

Section: Downloaded Fromsupporting

confidence: 64%

Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia

Tangerås

Austdal

Skråstad

et al. 2015

ATVB

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Objective-Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate disease-specific early pregnancy serum cytokine profiles of women subsequently developing gestational hypertension or preeclampsia for new insight into the underlying pathogeneses and differences between the disorders. Approach and Results-The study cohort consisted of 548 pregnant Norwegian women who were either multiparous with previous gestational hypertension or preeclampsia or were nulliparous. Maternal sera at gestational weeks 11 0 -13 6 were assayed for 27 cytokines, C-reactive protein, total cholesterol, high-density lipoprotein, triglyceride, creatinine, calcium, uric acid, and placental growth factor. Compared with normotensive women, women with both hypertensive conditions presented an atherogenic lipid profile at early gestation, but only those later developing gestational hypertension had significantly higher serum levels of interleukin (IL)-5 and IL-12. Comparing the 2 hypertensive pregnancy disorders, women subsequently developing gestational hypertension had higher serum levels of IL-1β, IL-5, IL-7, IL-8, IL-13, basic fibroblast growth factor, and vascular endothelial growth factor than the women subsequently developing preeclampsia. Conclusions-This study identifies early pregnancy differences in serum cytokine profiles for gestational hypertension and preeclampsia.

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Section: Downloaded Fromsupporting

confidence: 64%

Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia

Tangerås

Austdal

Skråstad

et al. 2015

ATVB

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“…They also found increased serum PlGF in PGDM, at least in the non-insulin-dependent subgroup. Newer data however found that serum PlGF was decreased in women with diabetes mellitus type 1 and in those with type 2 disease requiring treatment with insulin [14]. …”

Section: Discussionmentioning

confidence: 99%

“…Hypoxia and inflammation alter angiogenic and anti-angiogenic factors in the placenta [10], and maternal serum levels of PlGF are reduced in the first trimester of pregnancies that will develop preeclampsia (PE) or small for gestational age infants [11,12]. While earlier studies reported increased PlGF levels in pre-gestational diabetes (PGDM) and GDM [13], a recent publication demonstrated that in PGDM first-trimester maternal serum levels of PlGF are reduced [14], while yet another study showed again increased PlGF levels in pregnancies that developed GDM [15]. …”

Section: Introductionmentioning

confidence: 99%

First-Trimester Placental Growth Factor in Screening for Gestational Diabetes

Mosimann¹,

Amylidi²,

Risch

et al. 2015

Fetal Diagn Ther

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Objective: The aim of this study was first to assess whether first-trimester serum concentrations of placental growth factor (PlGF) differ between patients with and without gestational diabetes (GDM) and second to test whether there is a correlation between glycosylated hemoglobin (HbA1c), a factor recently shown to be useful in predicting GDM, and PlGF. Methods: PlGF was measured at 8-14 weeks with the Kryptor Immunoassay Analyzer (Brahms, Berlin, Germany). Absolute values were converted to multiples of the median using the software provided by the Fetal Medicine Foundation London. GDM was diagnosed using internationally accepted criteria. HbA1c levels were quantified using the TOSOH G7 automated hemoglobin analyzer. Results: From January to December 2014, 328 women were included in the study, 51 (15.5%) of whom developed GDM. First-trimester PlGF quantification does not discriminate between women at risk to develop GDM and controls, while HbA1c is able to do so. No correlation was found between PlGF and HbA1c. Conclusion: Our findings do not lend support to the hypothesis that early PlGF values are different in women who later develop GDM.

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“…PIGF levels also decrease in the second and third trimesters of pregnancy when PE is advanced or in women having SGA neonates. Thus, a relationship may exist between PE and SGA neonates [15].…”

Section: Pro-angiogenic Markersmentioning

confidence: 99%

Biomarkers and genetic factors for early prediction of pre-eclampsia

Kim

Shim

2017

J Genet Med

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JGMof the main causes of poor placental perfusion and leads to placental and fetal hypoxia. Hypoxia is a potent stimulus for release of the numerous factors into the maternal circulation that may affect endothelial function of maternal system, and this can be reason of hypertension and other signs of the disease.Currently, PE is thought to result from defective spiral artery remodeling, leading to cellular ischemia in the placenta and resulting widespread endothelial dysfunction of maternal multiorgan systems. Exact etiology underlying the cellular and molecular mechanisms of PE is still elusive. But recent observations support that altered expression of multiple factors is responsible for the clinical manifestation of the disease [4].PE is divided to 2 types; early-onset and late-onset PE. Earlyonset PE typically requires early delivery (before 34 weeks' gestation) as intrauterine growth retardation, unusual uterine and umbilical artery Doppler waveforms, and negative effects on the maternal and neonatal sides are common. Late-onset PE is commonly related to mild maternal disease and a low rate of

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Serum placental growth factor in the three trimesters of pregnancy: effects of maternal characteristics and medical history

Abstract: Objective To define the contribution of maternal variables which influence the measured level of maternal serum placental growth factor (PlGF)

Cited by 135 publications

References 24 publications

Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia

Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia

First-Trimester Placental Growth Factor in Screening for Gestational Diabetes

Biomarkers and genetic factors for early prediction of pre-eclampsia

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