Serum phosphohexose isomerase in cancer. III.As an index of tumor growth in metastatic carcinoma of the prostate

Bodansky, Oscar; Gershten, Blossom; Wilson, Charlotte

doi:10.1002/1097-0142(1955)8:6<1087::aid-cncr2820080603>3.0.co;2-k

Cited by 50 publications

(6 citation statements)

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“…Altcrations in the artivity of serum phosphohexose isornerasc, the enzyme that mediates the reversibIe conversion of glucose-6-phosphate to fruc tow-6-phosphate, were previously stndied in some detail in patients with metastatic' carcinoma of the breast7 or prostate. 8 The present study waq first concerned with demonstrating the existence in human serum of phosphoglucomutase, the en7yme that inimediately precedes pho5pliohexosc isomerase iri the glycolytic sequence and mediates the reversible conversion of glucose-I-phosphate to glucose-6-phosphate. The properties and normal range of activity of phosphoglucorriutase in human serum were then defined, and the activities of this cniyme were ( ompared with those of serum phosphohexose isomerase in normal persons.…”

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confidence: 99%

Phosphoglucomutase activity in human serum

Bodansky¹

1957

Cancer

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confidence: 99%

Phosphoglucomutase activity in human serum

Bodansky¹

1957

Cancer

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“…In fact, Bodansky and others considered GPI levels to be the best " index " of malignancy many years ago (Bodansky, 1954;Griffith and Beck, 1963). The presence of significantly increased serum levels of GPI in hamsters bearing an allogeneic melanoma would seem to support the contention that this enzyme marker is increased in the circulation with malignancy.…”

Section: Resultsmentioning

confidence: 99%

Carcinoembryonic antigen and glucose phosphate isomerase in a human colonic cancer model (GW-39)

Munjal¹,

Goldenberg²

1976

Br J Cancer

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Summary.-Levels of carcinoembryonic antigen (CEA) and glucose phosphate isomerase (GPI) have been compared in the circulating blood of hamsters bearing intra-muscular grafts of GW-39 human colonic tumour. CEA in the sera of GW-39 tumour-bearing hamsters ranged from 2 6 to 8-4 ng/ml (mean = 4-5 ± 1-7 ng/ml). GPI in the sera of normal hamsters ranged from 332 to 749 iu/l (mean = 602 ± 110 iu/l) while those with 14-week-old intra-muscular grafts of a hamster amelanotic melanoma, (A.Mel.3), or GW-39 human colonic carcinoma had a range of 664 to 1267 iu/l (mean = 1024 + 220 iu/l) and 1430 to 4719 iu/l (mean -2065 ± 601 iu/l) respectively.Thus, the ratio of enzyme activity in GW-39, A.Mel.3, and normal hamsters was 3 4:1-7:1, indicating a significant elevation (P < 0.01) in animals bearing a human colon carcinoma or a hamster melanoma, with particularly high values obtained in hamsters with GW-39.Sequential determinations of CEA and GPI in a group of hamsters transplanted intra-muscularly with GW-39 tumours revealed that both markers increased proportionately with duration of tumour growth, suggesting that both serum CEA and GPI may be used as measures of tumour growth. The concentration of GPI in GW-39 human colonic carcinoma xenografts was also significantly higher than that measured in normal human colon, primary human colonic cancer, or normal hamster tissues. These results support the view that GPI, in addition to CEA, is a quantitatively increased marker in this tumour model, and is liberated into the circulation in proportion to the increase in tumour mass.

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“…The serum phosphohexose isomerase activity was determined according to the mnethod of Bodansky (1954a). This determination was carried out on fresh serum obtained from normal controls, patients with variousnon-malignantdiseaseswith normal leukocyte counts, patients with chronic myelocytic and chronic lymphocytic leukaemia, and patients with leukocytosis due to infection.…”

Section: Miiaterials and Methodsmentioning

confidence: 99%

“…Fig. 2 Bodansky (1954bBodansky ( , 1955 has suggested that the rise in serum isomerase in metastatic malignancy may be due to either an excessive production of the enzyme in the new growth or to the easier access into the blood stream of the enzyme from the normal tissues in juxtaposition to the invading tumour. The high levels in chronic myelocytic leukemia may be due to increased production of the enzyme by the leukemic cells or more rapid loss of enzyme from the cells into the serum.…”

Section: Miiaterials and Methodsmentioning

confidence: 99%

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Serum Isomerase in Leukemia

Israels¹,

Delory²

1956

Br J Cancer

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Bodansky (1954a) recently described a method for the determination of serum isomnerase and examined the extent to which the serum enzyme activity can be correlated with clinical and biochemical evidence of tumour growth. He found good correlation in breast and prostatic cancer (Bodansky, 1954b(Bodansky, , 1955.In view of the considerable isomerase activity shown by erythrocytes and leukocytes, we have determined the serum isomerase concentrationi in diseases involving the cellular elements of the blood. MIIATERIALS AND METHODSThe serum phosphohexose isomerase activity was determined according to the mnethod of Bodansky (1954a). This determination was carried out on fresh serum obtained from normal controls, patients with variousnon-malignantdiseaseswith normal leukocyte counts, patients with chronic myelocytic and chronic lymphocytic leukaemia, and patients with leukocytosis due to infection. Many of the leukemia group were under treatment at the time of isomerase estimation. Those patients with chronic myelocytic leukemia were receiving radiation or dimethylsulphonoxylbutane (Myleran®), and those with chronic lymphocytic leukemia, radiation or p-(Di-2-chloroethylamino)-phenylbutyric acid (CB1348). Fig. 2 shows the relationship between the serum isomerase and the number of cells of the myelocytic series in chronic myelocytic leukemia before and after treatment, chronic lymphocytic leukemia and infection. In the chronic myelocytic

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Serum phosphohexose isomerase in cancer. III.As an index of tumor growth in metastatic carcinoma of the prostate

Cited by 50 publications

References 20 publications

Phosphoglucomutase activity in human serum

Phosphoglucomutase activity in human serum

Carcinoembryonic antigen and glucose phosphate isomerase in a human colonic cancer model (GW-39)

Serum Isomerase in Leukemia

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