Serum Phosphate in Stone Formers: What Does a Low Serum Phosphate Level Mean?

Dagnone, A. Joel; Norman, Richard W.

doi:10.1016/s0022-5347(05)67963-3

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…However, the importance of renal phosphate leak theory in the pathogenesis of calcium stone formation is controversial. In the study of Dagnone et al 42,. they concluded that serum phosphate did not appear to be an independent risk factor for the recurrence of urolithiasis, or a reliable early predictor of urolithiasis.…”

Section: Discussionmentioning

confidence: 95%

Association Study of Reported Significant Loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with Urolithiasis in Chinese Han Ethnicity

Wang

Feng

Ding

et al. 2017

Sci Rep

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In this study, we aimed to validate the association of 8 reported significant loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with urolithiasis in Chinese Han population. We performed case-control association analysis using 624 patients with nephrolithiasis and 1008 control subjects. We selected single-nucleotide polymorphism (SNPs) including rs12654812 and rs11746443 from 5q32.3; rs12669187 and rs1000597 from 7q14.3; rs7981733, rs4142110 and rs17646069 from 13q14.1 and rs4293393 from 16p12.3 which were previously reported to be associated with nephrolithiasis. We found none of these eight reported SNPs were significant associated with urolithiasis risk in Chinese Han population, which suggested that differences could exist in the mechanisms of calcium urolithiasis between Chinese and Japanese Ethnics. The A allele of rs12669187 was significantly correlated with increased level of serum magnesium. The C allele of rs1000597 was associated with higher levels of serum creatinine, uric acid, calcium and lower urine pH level. The T allele of rs4142110 was correlated with higher levels of serum magnesium, phosphorus, and lower AKP level. The G alleles of rs4293393 was associated with higher serum CO2 level. The risk alleles of these SNPs were proved to be associated with the electrolytes metabolism that may result in the formation of urolithiasis.

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Section: Discussionmentioning

confidence: 95%

Association Study of Reported Significant Loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with Urolithiasis in Chinese Han Ethnicity

Wang

Feng

Ding

et al. 2017

Sci Rep

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“…Tieder et al 26 proposed that an imbalanced phosphorus level is an important potential risk factor for urolithiasis. Dagnone and Norman 27 reported that serum phosphorus level was not an independent risk factor for urinary stone recurrence or complications. In our study, there were no significant differences in serum phosphorus between the two groups.…”

Section: Discussionmentioning

confidence: 98%

Preliminary analysis of serum electrolytes and body mass index in patients with and without urolithiasis

Zhang

Huang

et al. 2020

J Int Med Res

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Objectives To compare body mass index (BMI); serum parameters; and urine parameters between patients with and without urolithiasis. Methods Data from 1164 patients admitted to our Department of Urology from January 2011 to July 2013 were retrospectively reviewed; 714 patients (age, 5–87 years; male:female ratio, 1.8:1) exhibited urolithiasis, and 450 patients (age, 12–94 years; male:female ratio, 3.8:1) did not. Blood and urine were collected from patients the morning after hospital admission. Serum and urine parameters were checked by an automatic biochemistry analyzer. Statistical analysis included the Mann–Whitney U test and binary logistic regression. Results Serum sodium, potassium, chloride, calcium, phosphorus, and carbon dioxide combining power significantly differed between groups. In male patients, serum sodium, calcium, and phosphorus levels were higher in the urolithiasis group, whereas serum potassium and urine pH levels were lower. In female patients, serum sodium was higher in the urolithiasis group. BMI was higher in the urolithiasis group in all patients, male and female. Respective β-values of serum sodium and BMI in male patients were 0.077 and 0.084; in female patients, these values were 0.119 and 0.102. Conclusions Changes in serum sodium and BMI may be involved in the pathogenesis and treatment of urolithiasis.

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The Diagnostic Value of the Phosphate Levels in Serum and 24-hour Urine Samples in Patients with Recurrent Renal Stone Disease

Müezzinoğlu

Gümüş

Şener

et al. 2002

Scandinavian Journal of Urology and Nephrology

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Serum Phosphate in Stone Formers: What Does a Low Serum Phosphate Level Mean?

Abstract: Serum phosphate does not appear to be an independent risk factor for urinary tract stone recurrence or complications, or a reliable early predictor of occult disease.

Cited by 6 publications

References 8 publications

Association Study of Reported Significant Loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with Urolithiasis in Chinese Han Ethnicity

Association Study of Reported Significant Loci at 5q35.3, 7p14.3, 13q14.1 and 16p12.3 with Urolithiasis in Chinese Han Ethnicity

Preliminary analysis of serum electrolytes and body mass index in patients with and without urolithiasis

The Diagnostic Value of the Phosphate Levels in Serum and 24-hour Urine Samples in Patients with Recurrent Renal Stone Disease

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