Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8

Neurauter, Gabriele; Grahmann, A.V.; Klieber, Martin; Zeimet, Alain G.; Ledochowski, Maximilian; Sperner‐Unterweger, Barbara; Fuchs, Dietmar

doi:10.1016/j.canlet.2008.07.002

Cited by 105 publications

(90 citation statements)

References 29 publications

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“…This relationship has already been shown in patients with coronary artery disease [58] and in colorectal cancer [59]. Likewise in the blood of patients with ovarian cancer, a concurrent increase of neopterin and isoprostane-8 concentrations has been documented [60].…”

Section: Discussionmentioning

confidence: 71%

In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors

et al. 2010

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Section: Discussionmentioning

confidence: 71%

In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors

et al. 2010

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“…Two studies in this review showed reduced phenylalanine concentrations in patients with gastroesophageal cancer and another identified increased concentrations. Previous work has shown that activity of phenylalanine hydroxylase (which converts phenylalanine to tyrosine) is dysfunctional in inflammatory or malignant disease states (12,13). This raises the possibility that blood phenylalanine levels could be altered in patients with gastroesophageal cancer due to reduced action of this enzyme.…”

Section: Discussionmentioning

confidence: 99%

“…This conversion is catalyzed by the enzyme phenylalanine hydroxylase, which mainly functions in the liver, but has been shown to be active in other body tissues, including the kidney, pancreas, and brain (11). It has been shown that phenylalanine hydroxylase activity can be altered in inflammation or malignancy (12,13). Tyrosine is broken down into several metabolites, including L-DOPA, pyruvate, fumarate, and phenol.…”

Section: Introductionmentioning

confidence: 99%

Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Wiggins

Kumar

Markar

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Gastroesophageal cancer has a rapidly increasing incidence worldwide and reliable biomarkers are urgently required to facilitate earlier diagnosis and improve survival. The aromatic amino acids tyrosine, phenylalanine, and tryptophan represent potential biomarkers and their relation to gastroesophageal cancer will be evaluated in this review. An electronic literature search was performed to identify all published research relating to the measurement of tyrosine, phenylalanine, or tryptophan in the biofluids or tissues of patients with gastroesophageal cancer. Sixteen studies were included in this systematic review. Six studies investigated serum concentrations, which all found decreased concentrations of these aromatic amino acids, except one study that found increased phenylalanine. Five studies reported increased concentrations within gastric content of these patients and two reported increased urinary concentrations. Tissue concentrations of these aromatic amino acids were increased in three studies. Tyrosine, phenylalanine, and tryptophan represent potential biomarkers of gastroesophageal cancer, and further research is necessary to definitively establish the mechanism responsible for altered concentrations of these compounds in patients with gastroesophageal cancer. Cancer Epidemiol Biomarkers Prev; 24(1); 32-38. Ó2014 AACR.

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“…Subnormal concentrations of antioxidants, like vitamin C and E, have been observed in diseases associated with immune activation and inflammation, and may also impair availability of BH 4 in patients with malignancy (5,6). These clinical conditions are known to be linked with inflammation and immune activation and with increased concentrations of immune activation markers such as serum soluble 75 kDa tumor necrosis factor-α (sTNF-R75) and neopterin (7,8).…”

Section: 678-tetrahydrobiopterin (Bhmentioning

confidence: 99%

“…

AbstractBiopterin as a stable metabolite is produced by oxidation of 5,6,7, ). It is known that many diseases may cause changes in BH 4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity.

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mentioning

confidence: 99%

Urinary Biopterin Levels and Blood Dihydropteridine Reductase Activities in Patients with Thyroid and Breast Disorders

et al. 2010

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Biopterin as a stable metabolite is produced by oxidation of 5,6,7, ). It is known that many diseases may cause changes in BH 4 concentration and/or dihydropteridine reductase (DHPR) enzyme activity. There is only a limited number of studies correlating DHPR activity in malignancies. The main goal of the present study was to evaluate alterations in the DHPR activity and biopterin levels in patients with breast and thyroid cancers. The breast cancer patients (n=24) were compared to patients with benign breast diseases (n=19) and controls (n=30). In addition; the patients with thyroid cancer (n=17) were compared to patients with benign thyroid diseases (n=42) and the control group. We did not observe any significant difference between the benign disorders and the malignancies. Biopterin concentrations in patients with benign and malign thyroid and breast diseases were lower than the controls (all p <0.05). DHPR activities in thyroid diseases were significantly higher than the controls while insignificant decreases in DHPR activities in breast patients were detected. Our results suggested significant alterations in unconjugated pteridine pathway in thyroid and breast disorders.

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Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8

Cited by 105 publications

References 29 publications

In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors

In vitro testing for anti-inflammatory properties of compounds employing peripheral blood mononuclear cells freshly isolated from healthy donors

Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Urinary Biopterin Levels and Blood Dihydropteridine Reductase Activities in Patients with Thyroid and Breast Disorders

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