Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Wiggins, Tom; Kumar, Sacheen; Markar, Sheraz R.; Antonowicz, Stefan; Hanna, George B.

doi:10.1158/1055-9965.epi-14-0980

Cited by 96 publications

(79 citation statements)

References 35 publications

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“…In recent studies of tumor metabolomics, various amino acids have been demonstrated to be helpful for the study of potential biomarkers and pathogenesis of diverse malignancies (22). It has been found that alterations in amino acid metabolic profile show a correlation with GC, and the metabolic pathways of amino acids are abnormal in patients with GC (23,24) the levels of plasma aromatic amino acids, including tyrosine, phenylalanine and tryptophan, decreased overall in GC patients (25). Miyagi et al observed that citrulline, valine, tryptophan and histidine levels were significantly lower in GC patient plasma, whereas isoleucine and lysine were higher (26).…”

Section: Discussionmentioning

confidence: 99%

Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile

Jing

Cao

et al. 2018

IUBMB Life

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Patients with gastric ulcer (GU) have a significantly higher risk of developing gastric cancer (GC), especially within 2 years after diagnosis. The main way to improve the prognosis of GC is to predict the tumorigenesis and metastasis in the early stage. The objective of this study was to demonstrate the ability of human plasma amino acid metabolic profile for discriminating GC and GU. In this study, we first used liquid chromatography-tandem mass spectrometry technique to characterize the plasma amino acid metabolism in GC and GU patients. Plasma samples were collected from 84 GC patients and 82 GU patients, and 22 amino acids were detected in each patient. Partial least squares-discriminant analysis model was performed to analyze the data of these amino acids. We observed seven differential amino acids between GC and GU. A regression analysis model was established using these seven amino acids. Finally, a panel of five differential amino acids, including glutamine, ornithine, histidine, arginine and tryptophan, was identified for discriminating GC and GU with good specificity and sensitivity. The receiver operating characteristic curve was used to evaluate diagnostic ability of the regression model and area under the curve was 0.922. In conclusion, this study demonstrated the potential values of plasma amino acid metabolic profile and metabolomic analysis technique in assisting diagnosis of GC. More studies are needed to highlight the theoretical strengths of metabolomics to understand the potential metabolic mechanisms in GC. © 2018 IUBMB Life, 70(6):553-562, 2018.

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Section: Discussionmentioning

confidence: 99%

Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile

Jing

Cao

et al. 2018

IUBMB Life

View full text Add to dashboard Cite

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“…Lactate, threonine, acetate, uracil, succinate, lysine and tyrosine, myo-inositol, taurine and creatine have been shown to be associated with the presence of rectal cancer, and correlated with its progression (79). Taurine is also increased in squamous-cell carcinoma (80), while lactate has additionally been shown to be associated with oesophago-gastric cancer (81), along with fumurate, valine, glutamine, glutamate (81), xylonic acid (81, 82), tyrosine, phenylalanine, and tryptophan (83). Together these metabolites indicate a general dysregulation in the metabolism of cellular respiration, energy, amino acids, ketone body and choline metabolism which, as discussed, could be applicable to all cancers.…”

Section: Methodological Considerationsmentioning

confidence: 99%

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Kelly

Heiden

Giovannucci

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

105

111

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Metabolite profiling is being increasing employed in the study of prostate cancer as a means of identifying predictive, diagnostic and prognostic biomarkers. This review provides a summary and critique of the current literature. Thirty-three human case-control studies of prostate cancer exploring disease prediction, diagnosis, progression or treatment response were identified. All but one demonstrated the ability of metabolite profiling to distinguish cancer from benign, tumor aggressiveness, cases who recurred, and those who responded well to therapy. In the subset of studies where biomarker discriminatory ability was quantified, high AUCs were reported that would potentially outperform the current gold standards in diagnosis, prognosis and disease recurrence, including PSA testing. There were substantial similarities between the metabolites and the associated pathways reported as significant by independent studies, and important roles for abnormal cell growth, intensive cell proliferation and dysregulation of lipid metabolism were highlighted. The weight of the evidence therefore suggests metabolic alterations specific to prostate carcinogenesis and progression that may represent potential metabolic biomarkers. However, replication and validation of the most promising biomarkers is currently lacking and a number of outstanding methodological issues remain to be addressed in order to maximize the utility of metabolomics in the study of prostate cancer.

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“…The increases in Phe and Tyr in the urine of 5p− patients reflect disturbances in Phe metabolism and an imbalance in food products rich in Phe, an essential amino acid to the body and a precursor to Tyr, by action of Tyr hydroxylase enzyme (Wiggins, Kumar, Markar, Antonowicz, & Hanna, ). High concentrations of Phe are shown in phenylketonuric patients owing to hydroxylase Phe enzyme (EC: 1.14.16.1) failure (Zschocke, ).…”

Section: Discussionmentioning

confidence: 99%

Targeted analysis reveals alteration in pathway in 5p minus individuals

Furtado

Leite

Jedlicka

et al. 2020

Biomedical Chromatography

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Cri du Chat or 5p minus (5p−) syndrome is characterized by a deletion located on the chromosome 5 short (−p) arm and has an incidence rate of 1 in 50,000 individuals worldwide. This disease manifests in disturbances across a range of systems biochemicals. Therefore, a targeted metabolomics analysis was evaluated in patients with 5p− syndrome to help unravel the biochemical changes that occur in this disease. Urine samples were collected from people of both sexes aged 1–38 years old and analyzed by ultra‐performance liquid chromatography coupled to mass spectrometry. Student' statistical test, metabolomic pathway analysis and metabolite set enrichment analysis were applied to the data. Alterations of some amino acids and amine biogenics levels were found in Cri du Chat Syndrome individuals. The alteration of most of these metabolites is associated with energy recuperation and glycolysis. In general, we found the catabolism of some metabolic pathways to be affected in 5p− patients.

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Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Cited by 96 publications

References 35 publications

Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile

Discriminating gastric cancer and gastric ulcer using human plasma amino acid metabolic profile

Metabolomic Biomarkers of Prostate Cancer: Prediction, Diagnosis, Progression, Prognosis, and Recurrence

Targeted analysis reveals alteration in pathway in 5p minus individuals

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