Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis

Yamaguchi, Yukie; Ono, Junya; Masuoka, Miho; Ohta, Shoichiro; Izuhara, Kenji; Ikezawa, Zenrou; Aihara, Michiko; Takahashi, Koichiro

doi:10.1111/bjd.12117

Cited by 95 publications

(94 citation statements)

References 33 publications

(121 reference statements)

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“…Thus far, various factors—TGF-β1, 2, and 3, BMP2 and 4, vascular endothelial growth factor, connective tissue growth factor 2, vitamin K, valsartan, and IL-3 -4, -6, and –13—are known to induce periostin expression. 10 On the other hand, we and others have demonstrated that periostin is expressed in various inflammatory diseases/states such as AD, 12,15 IgG4-related sclerosing sialadenitis, 21 eosinophilic otitis media, 22 allergic rhinitis and chronic rhinosinusitis, 23 idiopathic or drug-induced pulmonary fibrosis, 24,25 scleroderma, 26 and proliferative diabetic retinopathy. 27,28 It has been largely undetermined what triggers periostin expression on each of these pathological states.…”

Section: Discussionmentioning

confidence: 94%

Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis

Arima

Takagi

Shiraishi

et al. 2015

Allergology International

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Background Epidermal hyperplasia is a histological hallmark observed in both atopic dermatitis (AD) and psoriasis, although the clinical features and the underlying immunological disorders of these diseases are different. We previously showed that periostin, a matricellular protein, plays a critical role in epidermal hyperplasia in AD, using a mouse model and a 3-dimensional organotypic coculture system. In this study, we explore the hypothesis that periostin is involved in epidermal hyperplasia in psoriasis. Methods To examine expression of periostin in psoriasis patients, we performed immunohistochemical analysis on skin biopsies from six such patients. To investigate periostin’s role in the pathogenesis of psoriasis, we evaluated periostin-deficient mice in a psoriasis mouse model induced by topical treatment with imiquimod (IMQ). Results Periostin was substantially expressed in the dermis of all investigated psoriasis patients. Epidermal hyperplasia induced by IMQ treatment was impaired in periostin-deficient mice, along with decreased skin swelling. However, upon treatment with IMQ, periostin deficiency did not alter infiltration of inflammatory cells such as neutrophils; production of IL-17, –22, or –23; or induction/expansion of IL-17– and IL-22–producing group 3 innate lymphoid cells. Conclusions Periostin plays an important role during epidermal hyperplasia in IMQ-induced skin inflammation, independently of the IL-23–IL-17/IL-22 axis. Periostin appears to be a mediator for epidermal hyperplasia that is common to AD and psoriasis.

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Section: Discussionmentioning

confidence: 94%

Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis

Arima

Takagi

Shiraishi

et al. 2015

Allergology International

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“…Serum periostin concentration has also been shown to correlate with dermatologic disease in patients with scleroderma, although not interstitial lung disease (33).…”

Section: Il-13mentioning

confidence: 99%

The Causal Role of IL-4 and IL-13 inSchistosoma mansoniPulmonary Hypertension

Kumar

Mickael

Chabon

et al. 2015

Am J Respir Crit Care Med

106

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Rationale: The etiology of schistosomiasis-associated pulmonary arterial hypertension (PAH), a major cause of PAH worldwide, is poorly understood. Schistosoma mansoni exposure results in prototypical type-2 inflammation. Furthermore, transforming growth factor (TGF)-b signaling is required for experimental pulmonary hypertension (PH) caused by Schistosoma exposure.Objectives: We hypothesized type-2 inflammation driven by IL-4 and IL-13 is necessary for Schistosoma-induced TGF-b-dependent vascular remodeling.Methods: Wild-type, IL-4 2/2

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“…Periostin has been associated with myofibroblastic differentiation in vivo and in vitro via an integrin-dependent mechanism as well as with ECM remodeling (60, 87). As a consequence, periostin increases are also associated with pathologies marked by a fibrotic condition such as idiopathic pulmonary fibrosis, renal fibrosis, asthma, and skin sclerosis in scleroderma (261,323,331,401).…”

Section: Periostinmentioning

confidence: 99%

The wound healing, chronic fibrosis, and cancer progression triad

Rybinski

Franco‐Barraza

Cukierman

2014

Physiological Genomics

198

169

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For decades tumors have been recognized as “wounds that do not heal.” Besides the commonalities that tumors and wounded tissues share, the process of wound healing also portrays similar characteristics with chronic fibrosis. In this review, we suggest a tight interrelationship, which is governed as a concurrence of cellular and microenvironmental reactivity among wound healing, chronic fibrosis, and cancer development/progression (i.e., the WHFC triad). It is clear that the same cell types, as well as soluble and matrix elements that drive wound healing (including regeneration) via distinct signaling pathways, also fuel chronic fibrosis and tumor progression. Hence, here we review the relationship between fibrosis and cancer through the lens of wound healing.

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Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis

Abstract: An elevated periostin level in patients with SSc is associated with severity of skin sclerosis. Periostin may be a potential biomarker for progressive skin fibrosis in SSc.

Cited by 95 publications

References 33 publications

Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis

Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis

The Causal Role of IL-4 and IL-13 inSchistosoma mansoniPulmonary Hypertension

The wound healing, chronic fibrosis, and cancer progression triad

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