Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects

Kimura, Hirokazu; Konno, Satoshi; Makita, Hironi; Taniguchi, Natsuko; Kimura, Hironobu; Goudarzi, Houman; Shimizu, Kaoruko; Suzuki, Masaru; Shijubo, Noriharu; Shigehara, Katsunori; Ono, Junya; Izuhara, Kenji; Ito, Yoichi M.; Nishimura, Masaharu

doi:10.1016/j.alit.2017.11.006

Cited by 29 publications

(22 citation statements)

References 45 publications

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“…The median (interquartile range [IQR]) periostin level was 50.1 (43.1 to 56.9) ng/ml, with a five-fold range of 28.1 to 136.4 ng/ml, and the 90% confidence limits were 35.0 to 71.1 ng/ml. There was no association between serum periostin levels and age, sex or common non-respiratory comorbidities, but serum periostin levels were lower in current smokers and lower in those with a high body mass index (BMI), consistent with other studies [40][41][42] . A related study showed a modest reduction in serum periostin levels in the evening, compared with morning testing (46.2 ng/ml at 1800 hr versus 50.5 ng/ml at 0800 hr) 43 .…”

Section: What Is Known About Periostinsupporting

confidence: 88%

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The Clinical Relevance of Periostin in Asthma

Braithwaite¹,

Semprini²,

Beasley³

2018

BRN

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Periostin is a matricellular protein which is generated by airway epithelial cells in response to interleukin (IL)-4 and IL-13. Serum periostin levels have been proposed as a biomarker of type-2 inflammation with clinical utility in severe asthma. Normal reference ranges have been established in a predominant Caucasian population using the Elecsys ® Periostin immunoassay. Periostin levels do not differentiate asthma from non-asthma, or mild-to-moderate asthma from severe asthma, although they are higher in adults with asthma who have raised levels of blood eosinophils and fractional exhaled nitric oxide (FeNO). Periostin status can predict response to monoclonal antibody therapy directed against IL-13 and immunoglobulin E (IgE), such that adults with severe asthma and a periostin level ≥ 50 ng/ml (designated "periostin-high") have a greater therapeutic response than "periostin-low" patients. The clinical relevance of these findings is uncertain, due to the similar predictive ability of the more commonly available biomarkers blood eosinophils and/or FeNO. (BRN Rev. 2018;4(4):258-73)

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Section: What Is Known About Periostinsupporting

confidence: 88%

“…Allergic rhinitis in non-asthmatics, but not in asthmatics, is associated with higher periostin levels 42 . Periostin has been implicated in the inflammatory and fibrotic pathways of atopic dermatitis 50 , psoriasis 51 and chronic rhino-sinusitis with nasal polyps 52,53 .…”

Section: Influence Of Type-2 Inflammatory Related Conditionsmentioning

confidence: 99%

The Clinical Relevance of Periostin in Asthma

Braithwaite¹,

Semprini²,

Beasley³

2018

BRN

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“…Class I obese participants showed higher POSTN plasma levels in comparison to overweight and class II-III obese patients, who exhibited the lowest POSTN plasma level. There was a controversial view in the literature where some studies have shown that BMI is in a negative association with serum POSTN in both healthy and asthmatic subjects, 43,44 while others showed that there is no significant correlation between BMI and serum POSTN level. 45 Due to the direct anatomic relation between the mouth and the upper airways and their similarity in cytokine composition with the lower airways in asthma, salivary analysis of POSTN could offer noninvasive rapid diagnostic aid in asthma control deterioration.…”

Section: Discussionmentioning

confidence: 99%

<p>Confounding Patient Factors Affecting the Proper Interpretation of the Periostin Level as a Biomarker in Asthma Development</p>

Hachim¹,

Elemam²,

Ramakrishnan³

et al. 2020

JAA

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Introduction: The proper use of serum periostin (POSTN) as a biomarker for asthma is hindered by inconsistent performance in different clinical settings. Objective: To explore patient's factors that may affect POSTN expression locally and systematically and its utility as a biomarker for asthma development. Materials and Methods: Here we used bioinformatics analysis of publicly available transcriptomics data to confirm that POSTN is an asthma specific gene involved in core signaling pathways enriched in the bronchial epithelium during asthma. We then explored a large number of datasets to identify possible confounders that may affect the POSTN gene expression and consequently, its interpretation as a reliable biomarker for asthma. Plasma and saliva levels of POSTN were determined in locally recruited asthmatic patients (mild, moderate and severe) compared to healthy controls to confirm the bioinformatics findings. Results: Our bioinformatics results confirmed that POSTN was consistently upregulated in the bronchial epithelium in asthma, chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) bronchial epithelium. In asthma, its mRNA expression was affected by gender, sample anatomical site and type, steroid therapy, and smoking. In our cohort, plasma POSTN was upregulated in severe and non-severe asthmatic patients. Saliva POSTN was significantly higher in non-severe asthmatic patients compared to healthy and severe asthmatic patients (specifically those who are not on Xolair (omalizumab)). Patients' BMI, inhaled steroid use and Xolair treatment affected POSTN plasma levels. Conclusion: Up to our knowledge, this is the first study examining the level of POSTN in the saliva of asthmatic patients. Both plasma and saliva POSTN levels can aid in early diagnosis of asthma. Saliva POSTN level was more sensitive than plasma POSTN in differentiating between severe and non-severe asthmatics. Patients' characteristics like BMI, the use of inhaled steroids, or Xolair treatment should be carefully reviewed before any meaningful interpretation of POSTN level in clinical practice.

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“…The level of serum POSTN in healthy controls averages 66.1 ng/mL, as reported by Kimura et al . 42 . The JESREC score used in the present study is calculated based on unilateral or bilateral disease, the presence of NPs, the dominant shadow of ethmoid sinuses in CT scans, and the eosinophil ratio in peripheral blood 7 .…”

Section: Discussionmentioning

confidence: 99%

Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps

Ninomiya

Noguchi

Tamano

et al. 2018

Sci Rep

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We previously reported that chronic rhinosinusitis with nasal polyps (CRSwNP) was subdivided into four chronic rhinosinusitis (CRS) subtypes using the JESREC scoring system. We sought to identify the gene expression profile and biomarkers related with CRSwNP by RNA-sequence. RNA-sequencing was performed to identify differentially expressed genes between nasal polyps (NPs) and inferior turbinate mucosa from 6 patients with CRSwNP, and subsequently, quantitative real-time PCR was performed to verify the results. ELISA was performed to identify possible biomarkers for postoperative recurrence. In the RNA-sequencing results, periostin (POSTN) expression was the highest in NP. We focused on POSTN and investigated the protein level of POSTN by immunohistochemistry and ELISA. POSTN was diffusely expressed in moderate and severe eosinophilic CRS using immunohistochemistry, and its staining pattern was associated with the severity of the phenotype of the CRSwNP (P < 0.05). There was a significant difference between the POSTN high/low groups for postoperative recurrence when the cutoff point was set at 115.5 ng/ml (P = 0.0072). Our data suggests that the protein expression level of POSTN was associated with the severity of CRSwNP, and serum POSTN can be a novel biomarker for postoperative recurrence of CRSwNP.

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Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects

Abstract: Our results provided clarity as to the factors associated with serum periostin levels, which could be helpful in the interpretation of serum periostin levels in clinical practice.

Cited by 29 publications

References 45 publications

The Clinical Relevance of Periostin in Asthma

The Clinical Relevance of Periostin in Asthma

<p>Confounding Patient Factors Affecting the Proper Interpretation of the Periostin Level as a Biomarker in Asthma Development</p>

Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps

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