Serum Parathyroid Hormone but Not Vitamin D Is Associated with Impaired Gait in Community‐Dwelling Older Adults

Montero‐Odasso, Manuel; Sakurai, Ryota; Hunter, Susan; Islam, Anam; Doherty, Timothy J.; Duque, Gustavo; Crilly, Richard G.

doi:10.1111/jgs.14501

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…It is also a risk factor for falls and impaired balance among elders ( de Franca et al, 2019 ). Previous studies indicated that elevated PTH concentration is associated with worse performance in the TUG test, lower gait speed, higher risk of sarcopenia, increased instability, and fall risk ( Visser et al, 2003 ; Montero-Odasso et al, 2016 ). Our results are in line with these observations.…”

Section: Discussionmentioning

confidence: 99%

12 Weeks of Physical Exercise Attenuates Oxidative Stress, Improves Functional Tests Performance, and Reduces Fall Risk in Elderly Women Independently on Serum 25(OH)D Concentration

et al. 2022

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The study aimed to evaluate if the 25(OH)D concentration is related to physical training responses. Moreover, to determine the association between serum 25(OH)D concentration and older women’s physical performance, oxidative stress markers, inflammation, and bone metabolism. 37 older women (age 72.9 ± 5.2 years) were assigned into two groups: supplemented (SG) and non-supplemented (NSG). Then, the participants from SG and NSG were randomly assigned into exercised and non-exercised groups: exercise sufficient vitamin D group (ESD; n = 10), exercise insufficient vitamin D group (EID; n = 9), control sufficient vitamin D group (CSD; n = 9), and control insufficient vitamin D group (CID; n = 9). To assess the study aims time up and go test (TUG), 6 min walk test (6MWT), fall risk test (FRT), blood osteocalcin (OC), parathormone (PTH), calcium (Ca2+), sulfhydryl groups (SH), malondialdehyde (MDA), and interleukin-6 (IL-6) were performed. The results showed that a higher 25(OH)D concentration was in line with better physical performance and bone metabolism as well as lower inflammation. After 12 weeks of training we noted an improvement in 6MWT (from 374.0 ± 17.3 to 415.0 ± 18.8; p = 0.001 and from 364.8 ± 32.8 to 419.4 ± 32.3; p = 0.001 for EID and ESD, respectively), TUG (from 7.9 ± 0.5 to 6.8 ± 0.8; p = 0.001 and from 7.3 ± 1.5 to 6.4 ± 0.9; p = 0.002, for EID and ESD, respectively), reduction of fall risk (from 2.8 ± 0.8 to 1.9 ± 0.4; p = 0.003 and from 2.1 ± 1.1 to 1.6 ± 0.5; p = 0.047, for EID and ESD, respectively) and increase in SH groups (from 0.53 ± 0.06 to 0.58 ± 0.08; p = 0.012 and from 0.54 ± 0.03 to 0.59 ± 0.04; p = 0.005, for EID and ESD, respectively), regardless of the baseline 25(OH)D concentration. A decrease in PTH and OC concentration was observed only in EID group (from 57.7 ± 15.7 to 49.4 ± 12.6; p = 0.013 for PTH and from 27.9 ± 17.2 to 18.0 ± 6.2; p = 0.004 for OC). To conclude, vitamin D concentration among older women is associated with physical performance, fall risk, inflammation, and bone metabolism markers. Moreover, 12 weeks of training improved physical performance and antioxidant protection, regardless of baseline vitamin D concentration.

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Section: Discussionmentioning

confidence: 99%

12 Weeks of Physical Exercise Attenuates Oxidative Stress, Improves Functional Tests Performance, and Reduces Fall Risk in Elderly Women Independently on Serum 25(OH)D Concentration

et al. 2022

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“…30,31 Níveis aumentados de PTH também foram associados ao pior desempenho físico, diminuição de massa muscular, osteosarcopenia, quedas e fraturas. 32,33 Os níveis de PTH elevam-se à medida que os níveis de VitD caem abaixo de 37 ng/ml, 34 no entanto, é observada uma variação nos níveis séricos de VitD levando em consideração as estações do ano, latitude, grupos raciais, o que leva a divergências sobre níveis circulantes adequados. 35 As recomendações apontam para níveis séricos acima de 20 ou 30 ng/ml.…”

Section: Discussionunclassified

Relationship between hematological, endocrine and immunological markers and sarcopenia in the elderly

et al. 2022

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Objective: To relate hematological, endocrine and immunological markers to the criteria for classifying sarcopenia in older people residents in the community. Method: Cross-sectional study, linked to the institutional research “Integrated Health Care for Older People”. The study population consisted of males and females aged 60 years or more and assisted in primary health care. The research protocol included an interview and physical examination to evaluate the sarcopenia criteria. Analysis of the following were done: complete blood count, 25-hydroxyvitamin D, parathyroid hormone, insulin-like growth factor-1, interleukin-6 and C-reactive protein. Statistical analysis included the Mann-Whitney test, Pearson's chi-square test, Fisher's exact test and Odds Ratio. Results: There was a relationship between interleukin-6 (p= 0,004), erythrocytes (p= 0,038), hemoglobin (p<0,001) and hematocrit (p= 0,002) with sarcopenia. It was also observed that the older people with altered muscular strength had lower values of hematocrit (p= 0,037) and higher of interleukin-6 (p= 0,002); and with altered physical performance had lower values of leukocytes (p= 0,024), hemoglobin (p<0,001), hematocrit (p= 0,007) and 25-hydroxyvitamin D (p= 0,034) and higher levels of parathyroid hormone (p= 0,018) and interleukin-6 (p= 0,002). Conclusion: It is suggested to evaluate and monitor the levels of interleukin-6, parathyroid hormone, 25-hydroxyvitamin D and the red blood count series during care practice.

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Calciotropic Hormones and Osteosarcopenia

Duval

Meytadier

Annweiler

et al. 2019

Osteosarcopenia: Bone, Muscle and Fat Interactions

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Serum Parathyroid Hormone but Not Vitamin D Is Associated with Impaired Gait in Community‐Dwelling Older Adults

Cited by 11 publications

References 9 publications

12 Weeks of Physical Exercise Attenuates Oxidative Stress, Improves Functional Tests Performance, and Reduces Fall Risk in Elderly Women Independently on Serum 25(OH)D Concentration

12 Weeks of Physical Exercise Attenuates Oxidative Stress, Improves Functional Tests Performance, and Reduces Fall Risk in Elderly Women Independently on Serum 25(OH)D Concentration

Relationship between hematological, endocrine and immunological markers and sarcopenia in the elderly

Calciotropic Hormones and Osteosarcopenia

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