Serum paraoxonase 1 activity and oxidant/antioxidant status in Saudi women with polycystic ovary syndrome

Mohamadin, Ahmed M.; Habib, Fawzia; Elahi, Thoraya Fadul

doi:10.1016/j.pathophys.2009.11.004

Cited by 45 publications

(41 citation statements)

References 43 publications

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“…The POase and/or AREase activities are reportedly lower (25,26,27,28) or similar (29,30) and the HTase activity is decreased (31) in PCOS patients compared with control women. However, the level, lactonase activity, and NLA of PON1 have not yet been assessed in PCOS patients.…”

Section: Introductionmentioning

confidence: 92%

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Zhang

Liu

et al. 2015

European Journal of Endocrinology

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Objective: To study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the PON1 genetic polymorphisms in women with polycystic ovarian syndrome (PCOS). Design: A case-control study. Methods: A total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) respectively. A normalized lactonase activity (NLA) was estimated based on the ratio of TBBLase:DEPCyMCase activity. The PON1 genotypes, serum malondialdehyde (MDA) levels and total antioxidant capacity were analyzed. Results: The lactonase activities and levels of PON1 were higher in PCOS patients than in the control women. However, the NLA did not significantly differ between groups. The K108C/T variation of the PON1 gene showed decreased lactonase activities and levels of PON1 in a genotype-dependent manner (CCOCTOTT); the 192Q/R variation of the PON1 gene showed increased PON1 lactonase activities and NLA; and the 55L/M variation of the PON1 gene showed decreased lactonase activities and levels of PON1 but an increased NLA. A multivariable regression analysis showed that the K108C/T, 192Q/R, and 55L/M variations of the PON1 gene, serum apolipoprotein A1, and MDA levels were significant predictors of PON1 lactonase activity, PON1 level, and NLA. Conclusions: The serum lactonase activities and concentrations of PON1 are increased in PCOS patients. The increased oxidative stress and the K108C/T, 192Q/R, and 55L/M genetic polymorphisms of PON1 may be associated with these changes.

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Section: Introductionmentioning

confidence: 92%

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Zhang

Liu

et al. 2015

European Journal of Endocrinology

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“…Patients were taken as obese if their body mass index was 29.9 [10]. Waist:hip ratio (WHR) was calculated by dividing waist by hip measurements [11].…”

Section: Anthropometric Measurementsmentioning

confidence: 99%

Effect of Goserlin Acetate and Oxidative Stress in Iraqi Women with Recurrenceof Endometriosis

Naji¹,

Rubae'I²,

Turki³

2016

IOSR

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“…The PON1 activity was reported to be reduced in insulin-resistant disorders, including PCOS (9,10). In a recent study on 35 Saudi PCOS patients, PON1 activity and antioxidant status were significantly decreased compared to those in 30 healthy controls (10).…”

Section: Introductionmentioning

confidence: 95%

Association of -108 C>T PON1 polymorphism with polycystic ovary syndrome

Ferk

Geršak

2013

Biomedical Reports

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Abstract. Polycystic ovary syndrome (PCOS) is possibly the most common endocrine disorder in premenopausal women. In this study, we aimed to investigate the association of the -108 C>T polymorphism in the PON1 gene, which encodes the antioxidant enzyme paraoxonase-1, with PCOS. A total of 118 women with PCOS and 108 control subjects were included in this case-control study. The PON1 polymorphism was genotyped, biochemical and clinical parameters were determined and the correlations between the parameters were statistically evaluated. The differences in the PON1 allele and genotype distributions between PCOS patients and controls did not reach a statistical significance. The serum fasting glucose (GLU) levels did not differ significantly between the PCOS patients and the controls. However, the serum fasting insulin (INS) concentration, INS̸GLU ratio and homeostasis model assessment (HOMA) index, although within the normal range, were significantly higher in the PCOS group. When considering PCOS patients and controls as separate groups or as a single group of patients, none of the analyzed biochemical or clinical parameters were found to be significantly correlated with the PON1 polymorphism. Therefore, the -108 C>T PON1 polymorphism was not found to be significantly associated with the presence of PCOS or with its particular clinical and biochemical characteristics in non-insulin resistant, non-obese patients.

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Serum paraoxonase 1 activity and oxidant/antioxidant status in Saudi women with polycystic ovary syndrome

Cited by 45 publications

References 43 publications

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome

Effect of Goserlin Acetate and Oxidative Stress in Iraqi Women with Recurrenceof Endometriosis

Association of -108 C>T PON1 polymorphism with polycystic ovary syndrome

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