Serum oxidizability and antioxidant status in patients undergoing in vitro fertilization

Aurrekoetxea, Igor; Ruiz-Sanz, José Ignacio; Agua, Ainhoa Ruiz del; Navarro, Rosaura; Hernández, M. Luisa; Matorras, Roberto; Prieto, Begoña; Ruiz‐Larrea, M. Begoña

doi:10.1016/j.fertnstert.2009.05.028

Cited by 51 publications

(46 citation statements)

References 41 publications

(50 reference statements)

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“…It is therefore necessary to be a balance between ROS production and elimination around spermatozoa. Something similar has been recently described in women undergoing IVF, suggesting a role for ROS in conception (6).…”

supporting

confidence: 78%

Glutathione peroxidase activity in seminal plasma and its relationship to classical sperm parameters and in vitro fertilization-intracytoplasmic sperm injection outcome

Crisol

Matorras

Aspichueta

et al. 2012

Fertility and Sterility

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supporting

confidence: 78%

Glutathione peroxidase activity in seminal plasma and its relationship to classical sperm parameters and in vitro fertilization-intracytoplasmic sperm injection outcome

Crisol

Matorras

Aspichueta

et al. 2012

Fertility and Sterility

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“…Other studies suggested that oocyte maturity did not vary with the changing levels of ROS and lipid peroxidation. 6 On the other hand, Aurrekoetxea et al 33 evaluated serum oxidizability and antioxidant status in women undergoing an IVF cycle to assess the pos-Okyay ve ark.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress Markers in IVF Patients and Their Association with Pregnancy Results

Okyay¹,

Aslan²,

Taşkın³

et al. 2014

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Oxidative stress has been well recognized as a component in the pathogenesis of many diseases, including female infertility. In this study, we aimed to investigate serum paraoxonase (PON1), arylesterase and myeloperoxidase (MPO) activities, and lipid hydroperoxide (LOOH) levels as oxidative stress markers along with their relationship with the pregnancy rate in women undergoing in vitro fertilization (IVF) treatment. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Serum samples of 179 subjects were collected immediately before starting ovarian stimulation and on ovum pick-up (OPU) day during IVF treatment. Stimulation protocol and starting doses were determined individually. When the leading follicle reached at least 17 mm in size, recombinant human chorionic gonadotropin (Ovitrelle, 250 mcg, Serono) was administered for ovulation induction. Serum basal/salt-stimulated paraoxonase, arylesterase activities, myeloperoxidase activity, and lipid hydroperoxide levels were compared between two samples. Subjects were also divided into two groups according to the presence of pregnancy, and the groups were compared in terms of oxidative stress markers studied. R Re es su ul lt ts s: : Serum MPO activity and LOOH levels were significantly higher on ovum pick up day (p<0.05, p<0.001, respectively), while basal/salt-stimulated paraoxonase and arylesterase activities were significantly lower (p=0.012, p=0.041, respectively) than those before ovarian stimulation. Serum LOOH levels on OPU day were significantly higher in non-pregnant group than pregnant one (p<0.001). Although basal/salt-stimulated paraoxonase, arylesterase and myeloperoxidase activities were higher in the non-pregnant group compared to the pregnant group, it was not statistically significant (p>0.05). C Co on nc cl lu us si io on n: : Ovarian stimulation during IVF treatment resulted in increased oxidative stress and decreased PON1 activity. However, changes in the studied parameters were not found to be significantly associated with the pregnancy results. Further studies are required to clarify our results.K Ke ey y W Wo or rd ds s: : In vitro fertilization; lipid peroxides; peroxidase; PON1 protein, human Ö ÖZ ZE ET T A Am ma aç ç: : Oksidatif stresin, kadın infertilitesi de dahil olmak üzere bir çok hastalığın patogenezinde yer aldığı gösterilmiştir. Bu çalışmada, in vitro fertilizasyon (IVF) tedavisi uygulanan kadın-larda oksidatif stres belirteçlerinden serum paraoksonaz (PON1), myeloperoksidaz (MPO), aril esteraz aktiviteleri ile lipid hidroksiperoksid (LOOH) düzeylerini ve bu belirteçlerin gebelik oranlarıyla ilişkisini araştırmayı amaçladık. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Yüz yetmiş dokuz olgunun serum örnekleri ovaryan stimulasyona başlanmadan hemen önce ve tedavi esnasında yumurta toplama günü (OPU) alındı. Stimulasyon protokolü ve başlangıç dozları bireysel olarak belirlendi. Dominant folikül boyutu en az 17 mm'ye ulaştığında, ovulasyonu tetiklemek için reko...

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“…A blood sample was extracted from the patients for genotyping. Ovarian cycle management and clinical pregnancy criteria have been previously published (10).…”

Section: Subjectsmentioning

confidence: 99%

“…In this respect, diabetes, a condition characterized by high blood glucose concentrations, represents a model of oxidative stress related to embryo toxicity (9). We have recently described that the IVF therapy leading to the ovarian stimulation produces a disturbance in the oxidant-antioxidant balance, causing the serum to be less protected against oxidation (10). A role for ROS in conception in IVF was also suggested (10).…”

mentioning

confidence: 99%

“…We have recently described that the IVF therapy leading to the ovarian stimulation produces a disturbance in the oxidant-antioxidant balance, causing the serum to be less protected against oxidation (10). A role for ROS in conception in IVF was also suggested (10). Other works in the literature have reported that women who became pregnant by IVF had higher levels of ROS (11) and lipid peroxidation (12) than those who did not.…”

mentioning

confidence: 99%

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Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles

Ruiz-Sanz

Aurrekoetxea

Matorras

et al. 2011

Fertility and Sterility

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Serum oxidizability and antioxidant status in patients undergoing in vitro fertilization

Cited by 51 publications

References 41 publications

Glutathione peroxidase activity in seminal plasma and its relationship to classical sperm parameters and in vitro fertilization-intracytoplasmic sperm injection outcome

Glutathione peroxidase activity in seminal plasma and its relationship to classical sperm parameters and in vitro fertilization-intracytoplasmic sperm injection outcome

Oxidative Stress Markers in IVF Patients and Their Association with Pregnancy Results

Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles

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