Serum Osteocalcin Is Not Associated with Glucose but Is Inversely Associated with Leptin across Generations of Nondiabetic Women

Lu, Chin‐Song; Ivaska, Kaisa K.; Alén, Markku; Wang, Qingju; Törmäkangas, Timo; Xu, Leiting; Wiklund, Petri; Mikkola, Tuija M.; Pekkala, Satu; Tian, Haoming; Väänänen, H. Kalervo; Cheng, Sulin

doi:10.1210/jc.2012-2045

Cited by 47 publications

(38 citation statements)

References 62 publications

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“…In this study, we found negative correlations between leptin and OC, ucOC and OPN levels only in healthy controls. Negative correlations between serum leptin and osteocalcin levels have been reported for non-diabetic women [49]; however, a study in women with type 2 diabetes reported no association [50]. In addition, ucOC, osteocalcin and osteopontin increased in two groups after delivery.…”

Section: Discussionmentioning

confidence: 94%

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women

Saucedo

Rico

Vega

et al. 2014

J Endocrinol Invest

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Section: Discussionmentioning

confidence: 94%

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women

Saucedo

Rico

Vega

et al. 2014

J Endocrinol Invest

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“…In this study, the measurement of total osteocalcin levels instead of the biologically active form ‘uncarboxylated osteocalcin' may appear as a limitation, but there is data confirming a lack of any connection between uncarboxylated osteocalcin and energy metabolism [33,34]. Moreover, carboxylation that depends on vitamin K intake in humans raises more confusion about the optimal activity of osteocalcin [35].…”

Section: Discussionmentioning

confidence: 99%

The Association of Osteocalcin and Adiponectin with Glucose Metabolism in Nondiabetic Postmenopausal Women

Çağlar¹,

Özdemir²,

Kiseli³

et al. 2014

Gynecol Obstet Invest

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Background/Aim: This study was designed to determine if osteocalcin is associated with insulin resistance, metabolic risk factors and adiponectin levels in nondiabetic postmenopausal women. Methods: A total of 87 menopausal nondiabetic subjects were enrolled into the study. Levels of fasting plasma glucose (FPG), insulin and serum lipids were determined. To estimate insulin sensitivity, homeostasis model assessment (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI) were used. Serum total osteocalcin and adiponectin levels were measured and the features of metabolic syndrome were identified. Results: The mean age of the patients was 54.7 years. Among the participants, 28.7% were obese (body mass index, BMI, ≥30). Insulin resistance was detected by HOMA-IR in 42.5% and by the QUICKI index in 63.2% of the cases. Metabolic syndrome was present in 29.8% of the patients. Neither the baseline characteristics nor the metabolic risk factors were correlated with osteocalcin or adiponectin levels (p > 0.05). When the patients were analyzed regarding BMI, osteocalcin levels were significantly lower in overweight women. Serum adiponectin levels were significantly lower in women with metabolic syndrome. Conclusion: No correlation between total osteocalcin and FPG, fasting insulin and insulin resistance parameters was found in nondiabetic postmenopausal women. Serum levels of adiponectin were associated with metabolic syndrome.

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“…Osteocalcin-null mice versus wild-type littermates have greater visceral fat, and consequently, present with hyperglycemia and are insulin resistant [3]. In humans, there is conflicting evidence for a relationship between tOC and glucose metabolism with some reports showing no relationship [18, 19], and others showing an inverse relationship between tOC and glucose concentrations [20–22]. In contrast, ucOC seems to play a role in pancreatic β-cell proliferation and insulin secretion, as well as improving peripheral insulin sensitivity through the regulation of the adipokine adiponectin [3, 4].…”

Section: Introductionmentioning

confidence: 99%

Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States

et al. 2017

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BackgroundThis study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9–13 years.MethodsThis was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9–13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed.ResultsApproximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boys and >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-β after adjusting for percent body fat. However, serum ucOC negatively correlated with leptin (partial r = −0.16; p = 0.04) and glucose (partial r = −0.16; p = 0.04) after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-β after adjusting for age, sex and percent body fat (all p < 0.001).ConclusionsThese data depict an inverse relationship between leptin and various metabolic health outcomes in children. However, the notion that tOC or ucOC link fat with energy metabolism in healthy children was not supported.Clinical trial registration number NCT00931580.

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Serum Osteocalcin Is Not Associated with Glucose but Is Inversely Associated with Leptin across Generations of Nondiabetic Women

Cited by 47 publications

References 62 publications

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women

Osteocalcin, under-carboxylated osteocalcin and osteopontin are not associated with gestational diabetes mellitus but are inversely associated with leptin in non-diabetic women

The Association of Osteocalcin and Adiponectin with Glucose Metabolism in Nondiabetic Postmenopausal Women

Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States

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