Serum Osteocalcin as a Diagnostic Biomarker for Primary Osteoporosis in Women

Singh, Sudhir; Kumar, Dharmendra; Lal, Atil Kumar

doi:10.7860/jcdr/2015/14857.6318

Cited by 54 publications

(41 citation statements)

References 20 publications

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“…An in vivo investigation in rodents showed that caffeine also seems to increase osteoclast numbers [ 39 ]. These data are consistent with the present result, considering that higher circulating OCN concentrations may be related to a reduced BMD in elderly subjects [ 40 , 41 ].…”

Section: Discussionsupporting

confidence: 94%

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample

et al. 2017

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Recent research suggested a metabolic implication of osteocalcin (OCN) in e.g. insulin sensitivity or steroid production. We used an untargeted metabolomics approach by analyzing plasma and urine samples of 931 participants using mass spectrometry to reveal further metabolic actions of OCN. Several detected relations between OCN and metabolites were strongly linked to renal function, however, a number of associations remained significant after adjustment for renal function. Intermediates of proline catabolism were associated with OCN reflecting the implication in bone metabolism. The association to kynurenine points towards a pro-inflammatory state with increasing OCN. Inverse relations with intermediates of branch-chained amino acid metabolism suggest a link to energy metabolism. Finally, urinary surrogate markers of smoking highlight its adverse effect on OCN metabolism. In conclusion, the present study provides a read-out of metabolic actions of OCN. However, most of the associations were weak arguing for a limited role of OCN in whole-body metabolism.

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Section: Discussionsupporting

confidence: 94%

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample

et al. 2017

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“…Serum osteocalcin is a diagnostic biomarker for primary osteoporosis in women (Singh et al, 2015). It is secreted by osteoblasts during the formative phase of bone remodeling (Civitelli et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Effect of Astragalus polysaccharides on ovariectomy-induced osteoporosis in mice

Huo¹,

Sun²

2016

Genet. Mol. Res.

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ABSTRACT. Postmenopausal osteoporosis, a common type of osteoporosis in women, has become a serious public health issue. Astragalus polysaccharides (APS), possessing various pharmacological activities, are the active ingredients of Radix Astragali. It can be advantageous in the treatment of postmenopausal osteoporosis. In the present study, we evaluated the potential therapeutic effects of APS on postmenopausal osteoporosis by using a mice model induced by ovariectomy (OVX). Forty-eight female 6-week-old outbred ICR mice were randomly divided into six groups (N = 8): Sham group, OVX group, 17 b-estradiol (E2, 0.1 mg/kg)-treated OVX group, and APS (at three doses: 100, 200, and 400 mg/kg)-treated OVX groups. The effect of APS on the bone mineral density (BMD) was determined using dualenergy X-ray absorptiometry. The serum levels of receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), osteocalcin, and tumor necrosis factor (TNF)-a were measured using ELISA kits. The results revealed that APS exerted significant antiosteoporotic activity by increasing the BMD considerably in a dosedependent manner. APS treatment reduced the serum RANKL levels considerably and increased the serum OPG levels, thereby lowering the ratio of RANKL/OPG. Furthermore, APS also markedly reduced osteocalcin and TNF-a concentration in OVX-induced postmenopausal osteoporosis mice model. These results showed that APS exerts a protective effect on bone loss in OVX mice. The molecular mechanism underlying this effect be the reduction of bone resorption and inhibition of osteoclastogenesis. Our findings suggest that APS may be a potential strategy for the prevention and treatment of postmenopausal osteoporosis.

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“…Table 1 summarizes that there is a tendency for serum osteocalcin levels and CAL to be higher in postmenopausal women with a high risk of osteoporosis than in the normal and osteopenia groups. Elevated serum osteocalcin levels have been found during periods of rapid bone turnover, as seen in osteoporosis, multiple myeloma, and fracture repair [13]. Osteocalcin can be used as a marker of bone formation to give an idea about the change in bone turnover when it is normalized with respect to resorption [19].…”

Section: Discussionmentioning

confidence: 99%

“…In osteoporosis, there is a deficiency of the calcium level and since osteocalcin is known as a calcium-dependent biomarker and has a strong affinity with hydroxyapatite responsible for bone mineralization. Osteoporosis leads to decreased hydroxyapatite crystal formation, and hence, results in an increase in serum osteocalcin levels [13].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Serum Osteocalcin Level and Periodontal Attachment Loss With Osteoporosis Risk Status in Postmenopausal Women

et al. 2018

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Objective: To assess the relationship between serum osteocalcin and periodontal clinical attachment loss (CAL) in postmenopausal women in relation to their osteoporosis risk status. Methods:A cross-sectional study was carried out on 71 postmenopausal women in Kenari District, Central Jakarta, Indonesia. The periodontal examination for all the subjects included a CAL measurement. The serum osteocalcin level was analyzed using ELISA. Results:The correlation between the serum osteocalcin level in patients with CAL and the risk of osteoporosis was analyzed with the Spearman test. The normal group had 29 subjects (40.84%), the osteopenic group had 23 subjects (32.39%), and the osteoporotic group had 19 subjects (26.76%). There was a significant correlation between CAL and the osteoporosis high-risk status (p<0.05) and no significant correlation between the serum osteocalcin level and the osteoporosis status (p>0.05). Conclusion:No correlation was found between CAL and the serum osteocalcin level (p>0.05).

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Serum Osteocalcin as a Diagnostic Biomarker for Primary Osteoporosis in Women

Cited by 54 publications

References 20 publications

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample

Comprehensive metabolic characterization of serum osteocalcin action in a large non-diabetic sample

Effect of Astragalus polysaccharides on ovariectomy-induced osteoporosis in mice

Correlation of Serum Osteocalcin Level and Periodontal Attachment Loss With Osteoporosis Risk Status in Postmenopausal Women

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