Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Abstract

Background and aim: Omentin-1 is suggested to affect inversely atherosclerosis (AS). Data about omentin-1 is limited to chronic kidney disease (CKD). Our aim was to examine omentin-1 in non-diabetic CKD patients who are not dialyzed and investigate its relationships with inflammation and carotid AS. Materials and Methods: We performed a cross-sectional study in 55 non-diabetic CKD patients and 30 healthy controls. Baseline clinical and laboratory data were obtained for all participants. Serum omentin-1 and interleukin-6 (IL-6) levels were measured according to the manufacturer's instructions. Carotic plaque and intima-media thickness (IMT) were assessed by carotid ultrasonography. The homeostasis model assessment of insulin resistance index (HOMA-IR) was used to assess IR. Results: Omentin-1 and IL-6 levels in the patient group were found to be higher than the control group; the differences were statistically significant (p ¼ 0.01 and p ¼ 0.04, respectively). Carotid IMT(mean) was significantly higher in the patient group (p ¼ 0.01). Omentin-1 did not correlate with IL-6 and IMT in the patient group (p ¼ 0.51 and p ¼ 0.76, respectively). In subgroup analysis, omentin-1 levels in patients with carotid plaque were lower than those without carotid plaque (179.5 AE 88.1 ng/ml and 185.9 AE 67.8 ng/ml, respectively). However, the difference was not statistically significant (p ¼ 0.47). Conclusion: We conclude that omentin-1 is higher in not dialyzed non-diabetic CKD and there is no correlation between omentin-1 and IL-6 or carotid IMT(mean).

Association of serum omentin levels with cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a hospital-based study

“…Until now, only a few studies have reported associations between omentin and subclinical atherosclerosis (e.g. carotid atherosclerosis) [ 12 , 25 ]. However, little information is available with respect to the associations of serum omentin levels and diabetic microvascular complications.…”

“…Serum omentin levels also are negatively correlated with BMI, metabolic risk factors and inflammatory markers, and positively correlated with serum adiponectin and high density lipoprotein-cholesterol (HDL-C) levels [ 8 – 11 ]. However, contradictory results also have been reported regarding the association of serum omentin with the above-mentioned metabolic risk factors [ 12 , 13 ].…”

Impact of plasma omentin levels on glucose metabolic disorders and early stage of endothelial dysfunction in elderly patients

“…More specifically, it is expressed in visceral adipose stromal vascular cells, rather than in subcutaneous adipose tissue 9 . Accumulating evidence indicates that the obese state is characterized by chronic low-grade inflammation and adipose tissue dysfunction, which leads to the initiation and progression of obesity-related disorders, such as T2DM, hypertension, and atherosclerosis 18 . We found in the present study, circulating omentin levels were lower in IGR group compared with NGT and were lowest in individuals with T2DM group.…”

Role of omentin and vaspin in metabolic diseases in association with psoriasis

“…Omentyna, jak opisano w piśmiennictwie, odgrywa w organizmie rolę przeciwzapalną [9][10][11]. Funkcja przeciwzapalna wiąże się z oddziaływaniem na szereg wewnątrzkomórkowych kaskad sygnalizacyjnych.…”

“…As the literature suggests, omentin has an anti-inflammatory role in the body [9][10][11]. The anti-inflammatory function is associated with its impact on a range of intracellular signal cascades.…”