Serum non-cholesterol sterols and cholesterol metabolism in childhood and adolescence

Gylling, Helena; Korhonen, Marie; Mutanen, Annika; Nissinen, Markku; Pakarinen, Mikko P.; Simonen, Piia

doi:10.1016/j.atherosclerosis.2018.09.017

Cited by 6 publications

(11 citation statements)

References 27 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Downregulated SREBP-2 processing would be expected to also lower PCSK9 levels, which would explain high LDL-receptor activity [59] (Figure 2). Changes in cholesterol homeostasis around puberty were also documented in healthy children/adolescents, with increased cholesterol absorption being reported at ages below 10 years, after which cholesterol synthesis prevails [108]. Data from the study also show a twofold increase in serum campesterol from the age of 1 year, which did not occur for sitosterol-the main dietary plant sterol.…”

Section: Plant Sterol Supplementation In Childhoodmentioning

confidence: 62%

See 1 more Smart Citation

Cardiovascular Disease Prevention: The Earlier the Better? A Review of Plant Sterol Metabolism and Implications of Childhood Supplementation

Scolaro

Andrade

Castro

2019

IJMS

View full text Add to dashboard Cite

Atherosclerosis is the underlying cause of major cardiovascular events. The development of atherosclerotic plaques begins early in life, indicating that dietary interventions in childhood might be more effective at preventing cardiovascular disease (CVD) than treating established CVD in adulthood. Although plant sterols are considered safe and consistently effective in lowering plasma cholesterol, the health effects of early-life supplementation are unclear. Studies suggest there is an age-dependent effect on plant sterol metabolism: at a younger age, plant sterol absorption might be increased, while esterification and elimination might be decreased. Worryingly, the introduction of low-cholesterol diets in childhood may unintentionally favor a higher intake of plant sterols. Although CVD prevention should start as early as possible, more studies are needed to better elucidate the long-term effects of plant sterol accumulation and its implication on child development.

show abstract

Section: Plant Sterol Supplementation In Childhoodmentioning

confidence: 62%

“…Data from the study also show a twofold increase in serum campesterol from the age of 1 year, which did not occur for sitosterol-the main dietary plant sterol. Whether the noncholesterol sterol absorption rate is increased remains to be elucidated [108].…”

Section: Plant Sterol Supplementation In Childhoodmentioning

confidence: 99%

Cardiovascular Disease Prevention: The Earlier the Better? A Review of Plant Sterol Metabolism and Implications of Childhood Supplementation

Scolaro

Andrade

Castro

2019

IJMS

View full text Add to dashboard Cite

show abstract

“…In 1 to 10-year-old children, absorption prevails over synthesis. 8 This finding shows the importance of dietary as a cholesterol-reduction tool among this age group.…”

mentioning

confidence: 80%

Alta Prevalência de Dislipidemias em Crianças e Adolescentes: Oportunidade para Prevenção

Mangili¹

2019

ABC Cardiol

View full text Add to dashboard Cite

Cardiovacular diseases are a major cause of morbidity and mortality. According with the World Health Organization (WHO), worldwide, one third of ischemic heart diseases are attributable to high cholesterol, which causes 2.6 million deaths per year. 1 Atherosclerosis begins in childhood and evolves in an insidious process which can last decades from the first artery injuries to the clinical outcomes (death, myocardial infarction or strokes). This process is speeded up by risk factors such as cholesterol, smoking, obesity and hypertension. 2

show abstract

“…The results of a small study by Matysik et al (67) suggested that the levels of plasma non-cholesterol sterols could serve as indicators of disrupted cholesterol homeostasis in patients with hyper-and hypothyroidism. Recently, plasma profile of non-cholesterol sterols from birth to 15 years of age was characterized in pediatric population without dyslipidemia (68). These data could form a solid base for future evaluation of the extent of cholesterol synthesis and absorption alterations in children and adolescents with AIT.…”

Section: Hashimoto Thyroiditis and Dyslipidemiamentioning

confidence: 99%

Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review

et al. 2019

View full text Add to dashboard Cite

Hashimoto autoimmune thyroiditis (AIT) is the most common cause of acquired hypothyroidism in the pediatric population. Development of AIT is mediated mainly by cellular immune response directed toward thyroid autoantigens, leading to inflammation and impaired function of thyroid gland. Both thyroid dysfunction and inflammation affect the metabolism of plasma lipoproteins. The alterations in lipid profile worsen with the advancement of hypothyroidism, ranging from discrete changes in euthyroid AIT patients, to atherogenic dyslipidemia in the overt hypothyroidism. In this review, characteristics of dyslipidemia in pediatric AIT patients, and the consequences in respect to the risk for cardiovascular disease (CVD) development are discussed. Additionally, benefit of L-thyroxine treatment on serum lipid profile in pediatric AIT patients is addressed. Finally, potential usefulness of novel lipid biomarkers, such as proprotein convertase subtilisin/kexin type 9 (PCSK9), non-cholesterol sterols, low-density lipoprotein particle size and number, and high-density lipoprotein structure and functionality in AIT patients is also covered. Further longitudinal studies are needed in order to elucidate the long-term cardiovascular outcomes of dyslipidemia in pediatric patients with Hashimoto AIT.

show abstract

Serum non-cholesterol sterols and cholesterol metabolism in childhood and adolescence

Cited by 6 publications

References 27 publications

Cardiovascular Disease Prevention: The Earlier the Better? A Review of Plant Sterol Metabolism and Implications of Childhood Supplementation

Cardiovascular Disease Prevention: The Earlier the Better? A Review of Plant Sterol Metabolism and Implications of Childhood Supplementation

Alta Prevalência de Dislipidemias em Crianças e Adolescentes: Oportunidade para Prevenção

Hashimoto Thyroiditis and Dyslipidemia in Childhood: A Review

Contact Info

Product

Resources

About