Serum Nitric Oxide and Plasma HbA1c Levels in Type 2 Diabetes Mellitus Patients

Ambiger, Sudha; Morkar, Dnyanesh N

doi:10.7860/jcdr/2019/41952.13139

Cited by 2 publications

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“…According to Manahan (1989) and Misko et al (1993), NO can also react with hemoglobin to form iron-nitrosyl adducts and/or nitrate in blood, with superoxide anion to make nitrate, and with amino and thiol groups of protein to form nitrosylated species. A growing variety of inflammatory and immunological disorders, including diabetes, have been linked to increased nitric oxide production in their disease progression and tissue damage (Jacob et al, 1992;Aly et al, 2017 andYousuf et al, 2019). Consistent with previous research, the GLE chosen for the current study intervention is abundant in bioactive substances, such as vitamins, carotenoids, flavonoids, and phenolics, all of which have demonstrated antioxidant properties in various biological systems (Wachtel-Galor et al, 2011 andSayed Ahmed et al, 2020).…”

Section: Effect Of Gle Intervention On Serum Oxidants Of Diabetic Ratsmentioning

confidence: 68%

Dietary Intervention using Reishi Mushroom (Ganoderma Lucidum) Reduces Oxidative Stress and Enhances Erythrocyte/Serum Defense Systems in Alloxan-Induced Diabetic Rats

Elhassaneen,

S. Aggad,

Mehram

2024

Alexandria Science Exchange Journal

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Diabetes mellitus (DM) is a metabolic disease that causes high blood glucose which is called hyperglycemia. In addition to hyperglycemia, oxidative stress, which raises the risk of complications, is one of the many other important factors that contribute significantly to the pathogenesis of diabetes. The goal of the current study was to determine how well (Ganoderma lucidum) ethanol extract (GLE) intervenes against oxidative stress in living cells, with a focus on its mechanistic elements in the management of diabetes mellitus. Rats treated with alloxan showed a significant (p≤0.01) increase in serum glucose levels from 92.67 mg/dL in normal control rats to 311.24 mg/dL in treated rats. Serum glucose levels in rats fed GLE (200, 400, 600, and 800 mg/kg bw) for 28 days showed a significant (p≤0.05) decline, with values recorded at 294.26, 268.34, 210.17, and 192.78, respectively. With GLE intervention, there was a dose-dependent increase in the rate of serum glucose decrease. The biochemical indicators of oxidative stress levels in plasma, nitric oxide (NO), malonaldehyde (MDA), and reactive oxygen species (ROS), all exhibited the same conduct. However, there was a notable (P≤0.05) increase in the various antioxidant protective mechanisms in the serum, which included bioactive molecules (GSH fractions), antioxidant vitamins (A, C, and E), and antioxidant enzymes [glutathione peroxidase (GSH-Px), glutathione reductase (GSH-Rd) superoxide dismutase (SOD) and catalases (CAT)]. Ultimately, these results establish a foundation for the application of (Ganoderma lucidum) extracts in the prevention and/or treatment of T2D by inhibiting oxidative stress, which is one of the factors contributing to the illness and its consequent challenges.

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Section: Effect Of Gle Intervention On Serum Oxidants Of Diabetic Ratsmentioning

confidence: 68%

Dietary Intervention using Reishi Mushroom (Ganoderma Lucidum) Reduces Oxidative Stress and Enhances Erythrocyte/Serum Defense Systems in Alloxan-Induced Diabetic Rats

Elhassaneen,

S. Aggad,

Mehram

2024

Alexandria Science Exchange Journal

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Glycated Hemoglobin is a Biomarker of Renal Failure in Diabetic Patients

Bayoumy¹

2022

J Inter Med Emer Res

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Objective: In diabetic patients, this condition leads the cause the chronic kidney disease commonly known as diabetic nephropathy or diabetic kidney disease. Diabetic kidney disease patients were an exceptional cohort of the population that had a noticeable high glycated hemoglobin along with a low glomerular filtration rate. Methodology: The recent cross-sectional study was based on a 790 participants sample size, having both normal and diabetic patients with various complications and severities related to renal function. This research is based on diabetes mellitus type 2 patients under the treatment in Farwaniyah hospital, Kuwait from 2007 to 2010. The patients were divided into four groups based on Diabetic + Renal failure (Diab+RF), Diabetic + non-Renal failure (Diab+ NRF), Nondiabetic +Renal failure (NDiab +RF) compared with normal individuals. Correlations were evaluated between HbA1c with all groups and the estimated glomerular filtration rate. Results: In this study, we observed that higher HbA1c may the reason for the decline in glomerular filtration rate, irrespective of general characteristics like age, sex, and Blood Pressure. Our results showed that 37% of diabetic patients with renal failure. Conclusion: We report that in clinical exercise glycated hemoglobin acted as a biomarker to predict the renal disease stage. Control glucose restricts the decline in glomerular filtration rate this act shows the value of glycemic variability in glomerular filtration rate descent. endothelial damages cause by High glycated hemoglobin levels with low plasma glucose in fasting.

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Serum Nitric Oxide and Plasma HbA1c Levels in Type 2 Diabetes Mellitus Patients

Cited by 2 publications

References 0 publications

Dietary Intervention using Reishi Mushroom (Ganoderma Lucidum) Reduces Oxidative Stress and Enhances Erythrocyte/Serum Defense Systems in Alloxan-Induced Diabetic Rats

Dietary Intervention using Reishi Mushroom (Ganoderma Lucidum) Reduces Oxidative Stress and Enhances Erythrocyte/Serum Defense Systems in Alloxan-Induced Diabetic Rats

Glycated Hemoglobin is a Biomarker of Renal Failure in Diabetic Patients

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