Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome

Abstract

Objective:Neutrophil gelatinase-associated lipocalin (NGAL) is a novel inflammatory marker that is released from neutrophils. In this study, we evaluated the correlation between serum NGAL level and clinical and angiographic risk scores in patients diagnosed with non-ST elevation acute coronary syndrome (NSTE-ACS).Methods:Forty-seven random NSTE-ACS patients and 45 patients with normal coronary arteries (NCA) who underwent coronary angiography were enrolled in the study. GRACE risk score and SYNTAX and Gensini risk scores were used, respectively, for the purpose of clinical risk assessment and angiographic risk scoring. Serum NGAL level was measured via ELISA in peripheral blood samples obtained from the patients at the time of admission.Results:Serum NGAL level was significantly higher in the NSTE-ACS group compared to the control group (112.3±49.6 ng/mL vs. 58.1±24.3 ng/mL, p<0.001). There was a significant positive correlation between serum NGAL levels and the GRACE (r=0.533 and p<0.001), SYNTAX (r=0.395 and p=0.006), and Gensini risk scores (r=0.575 and p<0.001). The intermediate-high SYNTAX (>22) group had statistically significantly higher serum NGAL levels compared to the low SYNTAX (≤22) group (143±29.5 ng/mL vs. 98.7±43.2 ng/mL, p=0.001).Conclusion:NGAL level was positively correlated with lesion complexity and severity of coronary artery disease in patients with NSTE-ACS. Serum NGAL levels on admission are associated with increased burden of atherosclerosis in patients with NSTE-ACS.

Circulating Lipocalin-2 Levels Are Associated With Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Levels In Type 2 Diabetic Patients

“…Some conflicting findings in the literature point that LCN-2 levels were significantly higher in acute coronary syndrome patients compared to subjects with normal coronary arteries [31] , however Giaginis et al [32] showed a contradictory result in which LCN-2 levels didn't differ between subjects with and without carotid artery stenosis.…”

Serum Neutrophıl Gelatınase-Assocıated Lıpocalın Levels in Patients with Non-Dipper Hypertension

“…Moreover, it is thought that NGAL secreted from endothelial cells might play a role in inflammation that is associated with endothelial dysfunction and atherosclerosis [13,24]. Recent studies have demonstrated that serum NGAL concentrations are increased in CAD and might contribute to the atherosclerotic process [16,25].…”

Diagnostic and Prognostic Significance of Neutrophil Gelatinase- Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndrome

“…In a similar study, 47 patients with NSTEMI confirmed via angiography were compared to 45 control patients with stable angina (having undergone coronary angiography and determined to have normal coronary arteries), and NGAL levels were positively correlated to lesion complexity and the diffusiveness of CAD in patients with NSTEMI. It was concluded that serum NGAL levels on admission are related to the increased atherosclerotic load in patients with Non-ST elevated Acute Coronary Syndrome(NSTE-ACS) (36).…”