Serum Neutrophıl Gelatınase-Assocıated Lıpocalın Levels in Patients with Non-Dipper Hypertension

Aksan, Gökhan; İnci, Sinan; Nar, Gökay; Sığırcı, Serhat; Gedikli, Ömer; Soylu, Korhan; Nar, Rukiye; Yüksel, Serkan; Şahin, Mahmut

doi:10.25011/cim.v38i1.22576

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…Hypertension itself triggers inflammation of vascular structures and increases the risk of atherosclerosis. 17 , 18 The epicardial fat tissue is not a simple fat tissue because it has metabolic and endocrine functions and secretes proinflammatory cytokines such as interleukin 1, interleukin 8, interleukin 6, and tumor necrosis factor α. Moreover, its vasocrine function allows for regulation of vascular tonus.…”

Section: Discussionmentioning

confidence: 99%

Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

2018

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ObjectiveEpicardial fat tissue thickness (EFT) and the neutrophil/lymphocyte ratio (NLR) are associated with atherosclerosis. Few studies have focused on the relationship between these parameters in patients with newly diagnosed hypertension. In this study, we examined the relationship between EFT and the NLR in patients with newly diagnosed hypertension detected by 24-hour ambulatory blood pressure monitoring (ABPM).MethodsEighty consecutive patients without chronic illness who were diagnosed with hypertension according to ABPM results and 80 otherwise healthy subjects were enrolled in the study. EFT of each participant was measured echocardiographically. The C-reactive protein (CRP) concentration and NLR were measured from venous blood samples.ResultsThe 24-hour average systolic blood pressure was significantly higher in the hypertension group than in the control group (143±17 vs. 117±7 mmHg, respectively). There were no significant differences in age, sex, or body mass index between the two groups. EFT, the NLR, and the CRP concentration were significantly higher in the hypertension group than control group. Additionally, a significantly positive correlation between EFT and the NLR was found in both the control group and hypertension group.ConclusionA higher EFT and NLR were detected in patients with newly diagnosed hypertension than in healthy subjects.

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Section: Discussionmentioning

confidence: 99%

Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

2018

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“…Moreover, as NGAL is an important biomarker of renal dysfunction, it may be helpful to detect kidney damage in the early stages of kidney failure in hypertensive individuals [ 206 ]. Serum NGAL concentrations correlate with ambulatory blood pressure values; thus, it is possible to diagnose a group of patients with a higher risk of cardiovascular diseases and mortality due to increased plasma NGAL [ 207 ].…”

Section: The Role Of Ngal In Cardiovascular Diseasesmentioning

confidence: 99%

The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL)

Romejko¹,

Markowska²,

Niemczyk³

2023

IJMS

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Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein that is secreted mostly by immune cells such as neutrophils, macrophages, and dendritic cells. Its production is stimulated in response to inflammation. The concentrations of NGAL can be measured in plasma, urine, and biological fluids such as peritoneal effluent. NGAL is known mainly as a biomarker of acute kidney injury and is released after tubular damage and during renal regeneration processes. NGAL is also elevated in chronic kidney disease and dialysis patients. It may play a role as a predictor of the progression of renal function decreases with complications and mortality due to kidney failure. NGAL is also useful in the diagnostic processes of cardiovascular diseases. It is highly expressed in injured heart tissue and atherosclerostic plaque; its serum concentrations correlate with the severity of heart failure and coronary artery disease. NGAL increases inflammatory states and its levels rise in arterial hypertension, obesity, diabetes, and metabolic complications such as insulin resistance, and is also involved in carcinogenesis. In this review, we present the current knowledge on NGAL and its involvement in different pathologies, especially its role in renal and cardiovascular diseases.

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“…All assays were performed in accordance with the manufacturer's instructions. Wide variations in serum NGAL values exist within the healthy population (median values ranging from 0.6 to 199 ng/ml) [46][47][48][49][50][51][52][53][54]. Herein, the median NGAL level in the whole healthy population (including smokers and non-smokers) was 11.09 ng/ml (with an interquartile range of 6.23-16.74).…”

Section: Elisasmentioning

confidence: 99%

Concomitant elevations of MMP‐9, NGAL, proMMP‐9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease

Bchir

Nasr

Bouchet

et al. 2016

J Cellular Molecular Medi

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A growing body of evidence points towards smoking‐related phenotypic differences in chronic obstructive pulmonary disease (COPD). As COPD is associated with systemic inflammation, we determined whether smoking status is related to serum levels of matrix metalloproteinase‐9 (pro‐ and active MMP‐9), neutrophil gelatinase‐associated lipocalin (NGAL) and the proMMP‐9/NGAL complex in patients with COPD. Serum samples were collected in 100 stable‐phase COPD patients (82 smokers, 18 never‐smokers) and 28 healthy adults (21 smokers, 7 never‐smokers). Serum levels of studied factors were measured in ELISA. Our data provide the first evidence of simultaneously elevated serum levels of MMP‐9, NGAL and proMMP‐9/NGAL in COPD smokers. While the triad discriminated between smokers and non‐smokers in the COPD group, MMP‐9 and proMMP‐9/NGAL (but not NGAL) discriminated between smokers with and without COPD. Adjustment for age and smoking pack‐years did not alter the findings. Serum MMP‐9, NGAL and proMMP‐9/NGAL levels were not correlated with the GOLD stage or FEV1 decline. Furthermore, serum levels of neutrophil elastase (NE) and MMP‐3 (but not of IL‐6 and MMP‐12) were also higher in COPD smokers than in healthy smokers before and after adjustment for age and pack‐years. Among COPD smokers, levels of MMP‐9, NGAL and proMMP‐9/NGAL were positively correlated with NE (P < 0.0001) but not with the remaining factors. Gelatin zymography detected proMMP‐9 in serum samples of healthy and COPD smoking groups. Our results suggest that associated serum levels of proMMP‐9, NGAL, proMMP‐9/NGAL and NE may reflect the state of systemic inflammation in COPD related to cigarette smoking.

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Serum Neutrophıl Gelatınase-Assocıated Lıpocalın Levels in Patients with Non-Dipper Hypertension

Cited by 6 publications

References 45 publications

Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

The Review of Current Knowledge on Neutrophil Gelatinase-Associated Lipocalin (NGAL)

Concomitant elevations of MMP‐9, NGAL, proMMP‐9/NGAL and neutrophil elastase in serum of smokers with chronic obstructive pulmonary disease

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