Serum neuron specific enolase may be a marker to predict the severity and outcome of cerebral venous thrombosis

Hu, Yanping; Meng, Ran; Zhang, Xuxiang; Guo, Linlin; Li, Sijie; Wu, Yan; Duan, Jiangang; Ding, Yuchuan; Ji, Xunming

doi:10.1007/s00415-017-8659-9

Cited by 25 publications

(29 citation statements)

References 25 publications

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“…[38,39] We obtained a positive correlation between the presence of NSE and a worse neurological status on the first day, and between S100B and a poor status on the first and 30th day of stroke, which is consistent with the observations reported by other authors. [15,[40][41][42] We observed a positive correlation between the concentrations of NSE and S100B.…”

Section: Discussionsupporting

confidence: 49%

The importance of selected markers of inflammation and blood-brain barrier damage for short-term post-stroke prognosis

Lasek–Bal

Jędrzejowska–Szypułka

Student

et al. 2018

Preprint

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Acute cerebral ischemia triggers local and systemic immune response. The aims of this project was to assess the blood serum concentration of the markers of inflammation and markers of the blood brain barrier damage on the first day of ischemic stroke, and the mutual correlations between these marker levels. Methods Our prospective study included 138 patients with first-in-life stroke, who were analyzed according to: plasma concentration of the following markers on the first day of stroke: Il-2 and IL-6, S100B, TNF alfa, GRN, NSE, uPA, VEGF, BDNF, CRP, leucocyte and thrombocyte counts; their neurological status on the first day of stroke (NIHSS) and their functional status at 30 days following stroke (mRS). Result The study included 138 patients with mean age: 73.11 ± 11.48 [36-103]. Patients with a higher score on the NIHSS than those obtaining lower scores showed significantly higher concentrations of TNF-alpha, WBC, CRP, NSE, IL-6 and S100B. Patients with a higher score on the mRS than those obtaining lower scores showed significantly higher concentrations of WBC, CRP, GRN, IL-6, S100B. Factors with an independent influence on the neurological status on the first day of stroke were: sex, WBC, PLT, CRP, S100B and IL-6 levels. Atrial fibrillation, leukocyte count, CRP, NSA, uPA, interleukin 6 and S100B showed an independent impact on the functional status on the 30th day of stroke. Patients with symptomatic atherosclerosis of carotid/cerebral and/or coronary arteries, as compared to others, were older (p= 0.003) and had higher levels of CRP, Il-6, and S100B. In each case, the differences were statistically significant. Conclusions The concentration of Il-6 and S100B on the first day of stroke are significant for both the neurological status and the functional status in the acute period of the disease. Increased CRP and leukocyte count are associated with a worse prognosis regarding the course of acute stroke. The expression of pro-inflammatory agents and markers of blood-brain barrier damage in the acute phase of stroke is more prominent in patients with symptomatic atherosclerosis than in patients with no clinical features of atherosclerosis.

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Section: Discussionsupporting

confidence: 49%

The importance of selected markers of inflammation and blood-brain barrier damage for short-term post-stroke prognosis

Lasek–Bal

Jędrzejowska–Szypułka

Student

et al. 2018

Preprint

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“…14 NSE could be a reliable marker of neuronal injury and show neuroprotection role as it controls neuronal survival and differentiation. 16 Several studies have suggested that unconjugated bilirubin was neurotoxic to astrocytes and neurons, and that its presence disturbed the release of neurotransmitters among neural synapses, leading to mitochondrial injury and neurocyte apoptosis. 16 Several studies have suggested that unconjugated bilirubin was neurotoxic to astrocytes and neurons, and that its presence disturbed the release of neurotransmitters among neural synapses, leading to mitochondrial injury and neurocyte apoptosis.…”

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confidence: 99%

“…15 High levels of serum NSE were noticed with cerebral venous infarction, intracranial hemorrhage, and seizure, which is positively associated with the severity of CVD in human. 16 Several studies have suggested that unconjugated bilirubin was neurotoxic to astrocytes and neurons, and that its presence disturbed the release of neurotransmitters among neural synapses, leading to mitochondrial injury and neurocyte apoptosis. 17 Although abnormally enhanced NSE and unconjugated bilirubin have been considered to be associated with the occurrence of atherosclerosis and CVD, the detailed relationship between NSE and bilirubin, and the pathogenesis and prognosis of LAAtype strokes have remained unclear.…”

mentioning

confidence: 99%

Association of serum neuron‐specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large‐artery atherosclerotic strokes

Wang¹,

Xu²,

Pan³

et al. 2018

J of Cellular Biochemistry

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“…Dynamic changes of the NSE serum levels in acute ischemic stroke are predictive for its hemorrhagic transformation and BBB disruption [78]. An association has also been found between the NSE serum levels and severity of cerebral venous thrombosis and NSE is regarded as a predictor of clinical outcome in this process [166]. Evaluation of the NSE levels has been recommended as a valuable indicator of poor outcome or death in the course of hypoxic-ischemic brain lesion after cardiac arrest [79,167].…”

Section: Neuron-specific Enolasementioning

confidence: 99%

Neurovascular Unit as a Source of Ischemic Stroke Biomarkers—Limitations of Experimental Studies and Perspectives for Clinical Application

Steliga

Kowiański

Czuba

et al. 2019

Transl. Stroke Res.

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Cerebral stroke, which is one of the most frequent causes of mortality and leading cause of disability in developed countries, often leads to devastating and irreversible brain damage. Neurological and neuroradiological diagnosis of stroke, especially in its acute phase, is frequently uncertain or inconclusive. This results in difficulties in identification of patients with poor prognosis or being at high risk for complications. It also makes difficult identification of these stroke patients who could benefit from more aggressive therapies. In contrary to the cardiovascular disease, no single biomarker is available for the ischemic stroke, addressing the abovementioned issues. This justifies the need for identifying of effective diagnostic measures characterized by high specificity and sensitivity. One of the promising avenues in this area is studies on the panels of biomarkers characteristic for processes which occur in different types and phases of ischemic stroke and represent all morphological constituents of the brains' neurovascular unit (NVU). In this review, we present the current state of knowledge concerning already-used or potentially applicable biomarkers of the ischemic stroke. We also discuss the perspectives for identification of biomarkers representative for different types and phases of the ischemic stroke, as well as for different constituents of NVU, which concentration levels correlate with extent of brain damage and patients' neurological status. Finally, a critical analysis of perspectives on further improvement of the ischemic stroke diagnosis is presented.

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Serum neuron specific enolase may be a marker to predict the severity and outcome of cerebral venous thrombosis

Cited by 25 publications

References 25 publications

The importance of selected markers of inflammation and blood-brain barrier damage for short-term post-stroke prognosis

The importance of selected markers of inflammation and blood-brain barrier damage for short-term post-stroke prognosis

Association of serum neuron‐specific enolase and bilirubin levels with cerebral dysfunction and prognosis in large‐artery atherosclerotic strokes

Neurovascular Unit as a Source of Ischemic Stroke Biomarkers—Limitations of Experimental Studies and Perspectives for Clinical Application

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