Serum neopterin in silicosis patients and workers exposed to inorganic dust

Prakova, G.; Slavov, E.; Gidikova, P.; Sandeva, G.; Deliradeva, R.

doi:10.14748/ssm.v41i1.474

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“…Consistent with our findings, Prakova et al reported serum neopterin levels to be high in miners exposed to asbestos and coal dust. 41 Increased neopterin levels have also been reported in miners exposed to bauxite dust, 42 while another study has suggested that levels are increased in tuberculosis which may be associated with the stimulation of cellular immune response. 43 Workers exposed to dust containing free crystalline silicon dioxide were found to have higher neopterin levels compared to the control group.…”

Section: Discussionmentioning

confidence: 97%

The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

et al. 2021

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Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group ( p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters ( p > 0.05) in the patient group. All biomarkers were positively correlated with each other ( p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.

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Section: Discussionmentioning

confidence: 97%