The usefulness of biomarkers in diagnosis of asbestos-induced malignant pleural mesothelioma

Abstract

Introduction: Malignant pleural mesothelioma (MPM) is a malignant tumor that is associated mostly with asbestos exposure. The present study was to evaluates the diagnostic value of neopterin, periostin, YKL-40, Tenascin-C (TNC), and Indolamine 2,3-dioxygenase (IDO) as noninvasive markers of malign pleural mesothelioma. Methods: Included in the study were 30 patients diagnosed with malign pleural mesothelioma, and 25 people as a control group. Biomarker levels were determined using an enzyme immunoassay . A Mann-Whitney U test and Spearman correlation methods were used for the statistical analysis. Results: All evaluated biomarkers were found to be significantly higher in the MPM group than in the control group ( p < 0.05). There was no effect of such variables as gender, age or MPMsubtype on the parameters ( p > 0.05) in the patient group. All biomarkers were positively correlated with each other ( p < 0.001). Conclusions: The current non-invasive biomarkers that can be used in the diagnosis of MPM yielded significant results and can make important contributions to the early diagnosis of MPM.

Pathological examination of Ym1, a chitinase family protein, in <i>Mesocestoides corti</i>-infected mice

“…It was reported that infection of Paragonimus kellicotti in Syrian hamsters induced reactive mesothelial hyperplasia (Weina and Burns 1992). Another chitinase-like protein, CHI3L1/YKL-40, is reportedly a useful biomarker for malignant pleural mesothelioma as well as lung cancer and asbestosis (Corradi et al 2013;Tanriverdi et al 2021). Although the function of mesothelial cells during parasitic infection is still unknown, up-regulated Ym1 in mesothelial cells may be involved in the regulation of immune response against parasitic infection by recruiting leukocytes into the pleural and peritoneal cavities.…”

Identification of Highly Sensitive Pleural Effusion Protein Biomarkers for Malignant Pleural Mesothelioma by Affinity-Based Quantitative Proteomics

“…This is not surprising as several of the identified proteins previously are associated with various cancers, including MPM (Table 5). For example, the increased expression of nipped-B-like protein is significantly linked with poor prognosis, tumor differentiation, and lymph node metastasis in non-small cell lung cancer [20], Beta ig-h3 plays a role in mesothelioma tumorigenesis and progression [21], periostin, haptoglobin, protein AMBP fragments are upregulated in various cancers including MPM [22][23][24], whereas galectin-3 binding protein are associated to prognosis and progression of various cancers [25]. Present in our dataset were also the proteins fibulin-3 and mesothelin-both originally proposed as biomarkers for MPM [7].…”

Chronic Inflammation, Oxidative Stress and Metabolic Plasticity: Three Players Driving the Pro-Tumorigenic Microenvironment in Malignant Mesothelioma

“…It is known that mesothelioma cells increase the expression of L-type Amino acid Transporter 1 (LAT1), depriving T-cells of amino acids, such as arginine and tryptophan, which are essential for T-cell function and proliferation [ 121 ]. Mesothelioma cells could also inhibit T-cell glycolysis and functions, increasing the levels of indoleamine-pyrrole 2,3-dioxygenase (IDO), which degrades tryptophan into kynurenine, a well-known immunosuppression factor [ 121 , 123 , 124 ]. In conclusion, the mesothelioma metabolome and secretome equally recruit and reprogram infiltrating immune cells [ 122 ].…”