Serum monoclonal immunoglobulins in childhood

Danon, F; Séligmann, M

doi:10.1136/adc.48.3.207

Cited by 25 publications

(3 citation statements)

References 18 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is of great interest that seven of the 14 herein reported patients were young children and further that seven of our patients (including five children) were affected with pri-mary immunodeficiency or were under immunosuppressive treatment. It is worth noting that most previously reported monoclonal Ig in children occurred in immunodeficient patients (10,11,15,16,24,29) and this finding is in accordance with our own data (8). The spontaneous disappearance of the monoclonal component(s) was noted in a child affected with a Wiskott-Aldrich syndrome (2) as well as in an infant with severe combined immunodeficiency in whom multiple homogeneous components were found after marrow and thymus transplantation (23).…”

Section: Discussionsupporting

confidence: 84%

Transient Human Monoclonal Immunoglobulins

Danon

Séligmann

1972

Scand J Immunol

Self Cite

View full text Add to dashboard Cite

Fourteen cases of transient serum monoclonal immunoglobulins are reported. Seven of the patients were young children. In 8 cases (including 5 children) a primary or secondary immunodeficiency could be ascertained. The level of the peak was under 1 g % in all cases except one, where the monoclonal Ig level was 2.5 g %. In 9 cases the monoclonal Ig disappeared in less than 2 months. The significance of these transient homogeneous components is discussed at both the clinical and aetiological level.

show abstract

Section: Discussionsupporting

confidence: 84%

Transient Human Monoclonal Immunoglobulins

Danon

Séligmann

1972

Scand J Immunol

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, he was suggested to have come down with MDS. A serum M-protein has been reportedly detected in elderly persons as well as in diseases other than B-cell malignancies [18][19][20]. Plural M-proteins observed in our elderly case with non-B cell leukemia would probably have come from his high age.…”

Section: Discussionmentioning

confidence: 58%

T-Cell Prolymphocytic Leukemia Accompanied by Plural M-Proteins with Myelodysplastic Syndroxme in a Nonagenarian

Saito¹,

Higashiura²,

Honma³

et al. 2012

J Clin Case Rep

View full text Add to dashboard Cite

T-cell Pro-Lymphocytic Leukemia (T-PLL) is a rare disease caused by malignancy of mature post-thymic T-cell. Myelodysplastic Syndrome (MDS) is caused by abnormal differentiation of myeloid lineage cells resulting in myeloid leukemia. Both of these hematological disorders are frequently diagnosed in elderly persons. Myeloid lineage is believed to be situated at the position far from lymphoid one as it is regarded on a tree diagram about the blood cell maturation. We reported herein a rare case of T-PLL accompanied by plural M-proteins with MDS a nonagenarian. The 96 years old patient was admitted to our hospital because of lymphocytosis and abnormal lymphocytes. From the bone marrow aspirate, biopsy and hematological findings, abnormalities were observed in cells of three different lineages, namely, (i) neutrophils with hypersegmented-nuclei (ii) erythroblasts with nuclear division, large platelets and megakaryoblastic cells, and (iii) reticulum cells with phagocytosed iron in their cytoplasm. Lymphocytes showed CD3 (+), CD4 (±), CD5 (+), CD8 (+), CD10 (+), CD56 (-) and CD57 (-). Mast cells and large lymphocytic cells with nuclear pockets were also seen. Anti-HTLV-1 antibody was negative. Soluble IL-2 receptor was significantly elevated to 7910 U/ml. Both IgGλ and IgGκM-protein were detected. No Bence-Jones protein was detected in the urine. Chromosomal abnormality of 45 (X, 0) or loss of Y chromosome was also demonstrated. Due to his high age, it was difficult to classify his condition according to the conventional classification. Thus, what we had experienced is truly a rare case that coincidentally showed T-PLL and MDS with plural M-proteins.

show abstract

“…On the other hand, the detection of M‐protein does not always imply a malignant stage in B cells. M‐protein has been detected in old people, 9 immuno‐compromised children, 10 renal transplant patients and early stages of Helicobacter pylori ‐positive gastric MALT lymphoma that is curable by antibiotics 11,12 . These do not seem to indicate that abnormal production of Ig may result in malignant transformation of the plasma cells in future.…”

Section: Discussionmentioning

confidence: 99%

Plural light chains in a single plasma cell of a monoclonal gammopathy undetermined significance case: An ultrastructural study

et al. 2007

View full text Add to dashboard Cite

A 44-year-old man was found to have M-proteins of IgG consisting of kappa- and lambda-chains in serum without lymphadenopathy or splenomegaly. The serum concentrations of IgG, IgA and IgM were within normal limits. Bone marrow examination showed normal cellular marrow containing 6.3% of plasma cells with no abnormal features. No chromosomal abnormality was observed at all. The patient was diagnosed as having monoclonal gammopathy of undetermined significance. The bone marrow plasma cells possessed free kappa- and lambda-chains in Golgi apparatus, rough endoplasmic reticula and cytoplasmic matrices. Plural light chains were simultaneously produced with the same heavy chain in a plasma cell by immunoelectron microscopy. This is the first report in the world of a monoclonal gammopathy of undetermined significance producing plural light chains with the same heavy chain.

show abstract

Serum monoclonal immunoglobulins in childhood

Cited by 25 publications

References 18 publications

Transient Human Monoclonal Immunoglobulins

Transient Human Monoclonal Immunoglobulins

T-Cell Prolymphocytic Leukemia Accompanied by Plural M-Proteins with Myelodysplastic Syndroxme in a Nonagenarian

Plural light chains in a single plasma cell of a monoclonal gammopathy undetermined significance case: An ultrastructural study

Contact Info

Product

Resources

About