Serum miR-146a and miR-223 as potential new biomarkers for sepsis

Wang, Jiafeng; Ming, Yu; Yu, Guang; Bian, Jinjun; Deng, Xiaoming; Wan, Xiaojian; Zhu, Keming

doi:10.1016/j.bbrc.2010.02.145

Cited by 305 publications

(266 citation statements)

References 30 publications

Supporting

Mentioning

246

Contrasting

Unclassified

Order By: Relevance

“…Firstly, numerous research groups studied the levels of cellular and in-plasma circulating miRNAs, as potential biomarkers, for sepsis (49,50). Our group observed in plasma of septic patients, that miR-150 is significantly downregulated and that its value correlates with the aggressiveness of the disease.…”

Section: The Mechanisms Behind the Complications The Mechanisms Behinmentioning

confidence: 99%

Patients After Splenectomy: Old Risks and New Perspectives

Dragomir¹,

Petrescu²,

Manga³

et al. 2016

chr

View full text Add to dashboard Cite

Rezumat Pacienåii post-splenectomie: complicaåii cunoscute aei perspective noiComplicaåiile care survin în urma splenectomiei pot fi împãråite în infecåioase aei non-infecåioase. Legãtura dintre splenectomie aei aceste riscuri este doar paråial înåeleasã. Rãspunsul imun al gazdei împotriva infecåiei este profund modificat post-splenectomie, iar aceaeti indivizi sunt mai susceptibili sã dezvolte sepsis aei infecåia are o evoluåie fulminantã. Splenectomia este de asemenea un potenåial factor de risc pentru numeroase complicaåii vasculare care rezultã în urma obstrucåiei paråiale sau totale ale unei artere sau vene. În plus, hipertensiunea pulmonarã poate fi o complicaåie severã aei uneori fatalã a splenectomiei. Unii autori includ aei neoplaziile, diabetul zaharat aei pancreatita acutã în categoria complicaåiilor non-infecåioase post-splenectomie. Cea mai de temut complicaåie pentru pacienåii splenectomizaåi rãmâne sepsisul. Fiziopatologia sepsisului încã este controversatã. Decesul în sepsis poate surveni fie în urma hiperinflamaåiei, fie în urma imunosupresiei. Multiple dovezi experimentale au dovedit implicarea microRNA-urilor celulare aei virale în sepsis. Considerãm faptul cã microRNA-urile sunt de asemenea asociate cu imunosupresia pacientului asplenic, ceea ce determinã o creaetere a riscului de sepsis fatal. Studierea nivelului expresiei plasmatice a microRNA-urilor circulante la pacienåii asplenici, ar putea conduce la o mai bunã înåelegere a imunosupresiei post-splenectomie aei la dezvoltarea unor noi metode diagnostice aei terapeutice.Cuvinte cheie: splenectomie, microRNA, sepsis, microRNA-uri virale, OPSI AbstractThe risks that arise after splenectomy can be divided in infectious and non-infectious. The link between splenectomy and these hazards remains partially unknown. Host defense against infection is altered after splenectomy and such individuals develop sepsis more easily and the infection has a fulminant course. Splenectomy is also a potential risk factor for several vascular complications that result from partial or total obstruction of an arterial or venous blood vessel. Furthermore, pulmonary hypertensioncan be a severe and sometimes fatal complication following splenectomy. Some authors also consider that malignancies, diabetes mellitus and acute pancreatitis are non-infectious complications after splenectomy. The most feared complication for splenectomized patients remains sepsis. The pathophysiology of sepsis is still controversial. Death in sepsis can occur due to either hyper-inflammation or "immune paralysis". Multiple experimental evidences link cellular and viral microRNAs with sepsis. We presume that General ReportChirurgia (2016)

show abstract

Section: The Mechanisms Behind the Complications The Mechanisms Behinmentioning

confidence: 99%

Patients After Splenectomy: Old Risks and New Perspectives

Dragomir¹,

Petrescu²,

Manga³

et al. 2016

chr

View full text Add to dashboard Cite

show abstract

“…Plasma levels of miR-150 decreased significantly 53 while serum miR-146a and miR-223 were significantly reduced in septic patients compared with controls. 54 Not only are new biomarkers for determining the severity of the condition important, new biomarkers are also needed in the search for septic treatment. Decreased plasma miR-150 levels correlated with disease severity measured by the clinically used SOFA score, and the ratio of plasma levels of miR-150/ IL-18 was sufficient for assessing sepsis severity.…”

Section: Circulating Mirnas In Tissue Injury and Infectionmentioning

confidence: 99%

Small RNAs have a large impact

et al. 2012

View full text Add to dashboard Cite

“…Serum and whole blood have proved an acceptable source of EV-derived miRNA profiles, thus providing a potential blood-borne biomarker candidate for various disease and physiological states (Häusler et al, 2010;Reid et al, 2011). Human based disease research has revealed significant differences in miRNA abundance for many cancers (Lawrie et al, 2008;Häusler et al, 2010), heart disease (Tijsen et al, 2010) and sepsis (Wang et al, 2010). In addition, circulating miRNAs in maternal serum have been observed as potential biomarkers of pregnancy status due to their significant impact on gene expression and regulation (Chim et al, 2008).…”

Section: Mirnas: Potential Biomarkers For Pregnancy Diagnosismentioning

confidence: 99%