Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

Gu, Xiaosong; Zhao, Liang; Zhu, Jing; Gu, Huiying; Li, Hui; Wang, Luchen; Xu, Weiting; Chen, Jianchang

doi:10.1161/jaha.115.002010

Cited by 16 publications

(14 citation statements)

References 36 publications

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“…Based on a cross-section study of 14866 hypertensive participants, this study found that baPWV ≥1400 cm/s was universal in hypertensive participants, with a prevalence of 87.2%. It was nearly the same as research by Zhang et al [23] and Gu et al [24], although the studies were based on different size of sample. In addition, almost half of the hypertensive participants in our study were considered in one study to be at risk of moderate arteriosclerosis, which has been considered to be an independent factor in indicating the relapse of cardiovascular diseases (CVD) as well as an irreversible progress of AS [25].…”

Section: Discussionsupporting

confidence: 55%

Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China

et al. 2019

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Background The aim of this study was to investigate the association between body mass index (BMI) and brachial-ankle pulse wave velocity (baPWV) in hypertensive males. Material/Methods Altogether, 14 866 male hypertensive participants were included in the analysis. Participants were divided into 3 groups: low BMI group (BMI <24 kg/m 2 ), moderate BMI group (24 kg/m 2 ≤BMI <28 kg/m 2 ), and high BMI group (BMI ≥28 kg/m 2 ). According to baPWV values, arteriosclerosis (AS) was set as 3 degrees: mild AS (baPWV ≥1400 cm/s), moderate AS (baPWV ≥1700 cm/s) and severe AS (baPWV ≥2000 cm/s). Multivariate logistic regression analysis was used to explore the effect of different BMI groups on different degrees of AS. The multivariate linear regression analysis was used to explore the relationship between BMI and baPWV. Results Among low BMI, moderate BMI, and high BMI groups, the average baPWV values were 1824±401 cm/s, 1758±363 cm/s, and 1686±341 cm/s, respectively. Prevalence in the mild, moderate and high BMI groups were 91.0%, 87.8%, 81.5%, respectively for mild AS; 55.3%, 48.8%, and 40.0% respectively for moderate AS; and 25.9%, 20.2%, and 14.9% respectively for severe AS. Compared to the low BMI group, multivariate logistic regression analysis showed that odds ratio (OR) and 95% confidence intervals (95%CI) in the moderate BMI group and the high BMI were 0.71 (95%Cl, 0.62–0.80), 0.43 (95%Cl, 0.38–0.50) for mild AS; and similar trends were shown for moderate AS and severe AS. Based on age-stratification, a negative relationship remained for 35–55 years old participants for different degrees of AS among the moderate BMI group and the high BMI group. A negative relationship was detected between BMI and baPWV in total and different age-stages. Conclusions Among male hypertension participants in this study, there was a negative relationship between BMI and baPWV. High BMI was found to be a protective factor for AS especially in the age range of 35–55 years.

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Section: Discussionsupporting

confidence: 55%

Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China

et al. 2019

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“…It is excreted to urine after glomerular filtration. Gu et al 29 found that the level of baPWV was increased with the elevation of creatinine, and creatinine was an independent risk factor of arterial stiffness in hypertensive. Resting heart rate has recently been regarded as cardiovascular risk factor in the general population as well as in individual persons suffered from cardiovascular diseases 30,31 .…”

Section: Discussionmentioning

confidence: 99%

Relationship between high‐normal albuminuria and arterial stiffness in Chinese population

Gong

Wang

et al. 2020

J of Clinical Hypertension

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Microalbuminuria, a hazard factor of cardiovascular events in hypertensives, diabetics, and general population, 1-3 is defined as urinary albumin-to-creatinine ratio (UACR) between 30 and 300 mg/g. 4 It is generally believed that microalbuminuria is not only an indicator of glomerular endothelial damage representing microvascular injuries, but also reflects widespread vascular damage. 5 Actually, endothelial injury occurs at the same time in both large and small arteries. Arterial wall consists of endothelium, smooth muscle cells, adventitia fibroblasts, and extracellular matrix. 6 Recently, high-normal albuminuria, a higher degree of albuminuria below the diagnostic threshold for microalbuminuria, was found to be related with adverse cardiovascular events, which can

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“…Hypertensive patients have a higher ET-1 than healthy controls. 18 Circulating levels of ET-1 and endogenous ET(A)-mediated constriction are increased in human aging. 19 ET-1 is also involved in progression of renal hypertension.…”

Section: Discussionmentioning

confidence: 99%

Inverse Correlation Between Plasma Adropin and ET-1 Levels in Essential Hypertension

Zhu

et al. 2015

Medicine

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Adropin is a recently identified bioactive protein that promotes energy homeostasis by affecting glucose and lipid metabolism. Recently, adropin has also been reported to be associated with endothelial dysfunction. Also, ET-1, as a biomarker for endothelial dysfunction, is a key regulator in hypertension. Accordingly, the aim of the present study was to detect the relationship between plasma adropin and ET-1 levels in hypertension.A total of 123 participants, diagnosed with primary hypertension on the basis of World Health Organization criteria (systolic blood pressure [SBP] ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg), and 58 normotensive subjects were enrolled in the cross-sectional study from October 2011 to December 2013. All study participants were older than 18 years of age. Adropin and ET-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).We found that plasma adropin levels were significantly lower in hypertensives compared with controls (3.18 ± 1.00 vs 4.21 ± 1.14 ng/mL, P < 0.001). Plasma ET-1 levels were higher in hypertensives than controls (2.60 ± 1.14 vs 1.54 ± 0.66 pg/mL, P < 0.001). Adropin had a negative correlation with DBP (r = −0.40, P < 0.001), SBP (r = −0.49, P < 0.001), and adjusted for age, body mass index, SBP, DBP, glucose, TC, TG, LDL, and Cr, there was a negative correlation between ET-1 and adropin (r = −0.20, P = 0.04). In multivariate logistic regression analysis of the variables, ET-1 (odds ratio [OR], 3.84; 95% CI, 2.16–6.81; P < 0.001) and adropin (OR, 0.99; 95% CI, 0.99 −1.0; P < 0.001) were found to be independent predictors for hypertension.In conclusion, decreased plasma adropin levels are associated with increased blood pressure in hypertension. Adropin is an independent predictor for hypertension, and may influence blood pressure by protecting endothelial function.

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Serum Mimecan Is Associated With Arterial Stiffness in Hypertensive Patients

Cited by 16 publications

References 36 publications

Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China

Association Between Body Mass Index (BMI) and Brachial-Ankle Pulse Wave Velocity (baPWV) in Males with Hypertension: A Community-Based Cross-Section Study in North China

Relationship between high‐normal albuminuria and arterial stiffness in Chinese population

Inverse Correlation Between Plasma Adropin and ET-1 Levels in Essential Hypertension

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