Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals

Hana, Claudia A.; Tran, Lan V.; Mölzer, Christine; Müllner, Ernst W.; Hörmann-Wallner, Marlies; Franzke, Bernhard; Tosevska, Anela; Zöhrer, Patrick A.; Doberer, Daniel; Marculescu, Rodrig; Bulmer, Andrew Cameron; Freisling, Heinz; Moazzami, Ali A.; Wagner, Karl‐Heinz

doi:10.1016/j.metabol.2021.154913

Cited by 6 publications

(3 citation statements)

References 69 publications

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“…Consistently, patients with Gilbert’s syndrome had reduced TC and LDL-C levels when compared to matched controls ( 19 , 28 , 29 ). Bilirubin could promote lipid catabolism and inhibit lipid accumulations ( 30 , 31 ). Bilirubin might bind to PPARα and promote β-hydroxybutyrate, and then activate hepatic β-oxidation pathway, thus boosting lipid metabolism ( 32 , 33 ).…”

Section: Discussionmentioning

confidence: 99%

Serum Bilirubin Level Is Increased in Metabolically Healthy Obesity

Wang

Zhang

et al. 2022

Front. Endocrinol.

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ObjectivesBilirubin is a biochemical substance with metabolic benefits. The objective of this research was to elucidate the association between serum bilirubin levels and metabolic alterations in different obesity phenotypes.MethodsIn total, 1,042 drug-naive participants were included in the study. Of them, 541 were obese patients and 501 were age-matched and sex-matched healthy control subjects. The obese patients were divided into metabolically healthy obesity (MHO) group and metabolically unhealthy obesity (MUHO) group according to the levels of fasting plasma glucose (FBG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and blood pressure (BP). Clinical and biochemical parameters including total bilirubin (TBil), indirect bilirubin (IBil) and direct bilirubin (DBil) were measured. ANOVA or Kruskal-Wallis H test was used to test differences among the three groups. Pearson and Spearman correlations were used to analyze the relationships between two parameters. The relationships between bilirubin and other variables were analyzed using Multivariate regression analysis.ResultsMHO group had favorable blood pressure, glucose and lipids profiles, along with increased TBil and DBil, and decreased high-sensitivity C-reactive protein (hsCRP) and homeostasis model assessment of insulin resistance (HOMA-IR) levels when compared to MUHO group (P < 0.05 for all). TBil and DBil were negatively correlated with total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting insulin (FINS), hsCRP and HOMA-IR, even after adjusted for age, gender and BMI (all P <0.01). Multivariate regression analysis demonstrated that HOMA-IR was independently correlated with TBil and DBIi levels (β = -0.400, P < 0.01).ConclusionMHO group harbors increased bilirubin level compared with MUHO group. HOMA-IR was independently correlated with TBil and DBIi levels.

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Section: Discussionmentioning

confidence: 99%

Serum Bilirubin Level Is Increased in Metabolically Healthy Obesity

Wang

Zhang

et al. 2022

Front. Endocrinol.

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“…As a result, bilirubin was highlighted as a promising future target in obese and dyslipidemic patients. 32 …”

Section: Discussionmentioning

confidence: 99%

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Schoissengeier,

Maqboul,

Weber

et al. 2024

iScience

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“…В работе Hana C. A. и соавт. было выявлено улучшение показателей углеводного обмена на фоне СЖ, в частности, продемонстрировано снижение уровня гликемии натощак (р = 0,006), HOMA-IR (р = 0,001), С-пептида (р = 0,001) и тенденцию к снижению уровня HbA1c (р = 0,062) по сравнению с пациентами без СЖ [47].…”

Section: позитивные клинические «сценарии» нарушение углеводного обменаunclassified

Gilbert’s syndrome as a model for studying the effects of bilirubin

Loshkova

Doroshenko

Yankina

et al. 2023

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Numerous scientific studies conducted over the past years expand our understanding of the physiological and pathophysiological effects of bilirubin. In this review of the literature, the authors, using the example of Gilbert’s syndrome, as a classic condition occurring with hyperbilirubinemia, discuss the results of clinical and experimental studies demonstrating the protective mechanisms and the protective role of elevated bilirubin concentration in relation to diseases accompanied by metabolic inflammation, oncological diseases, and a number of others. The authors focus on the hormonal function of bilirubin and its potential therapeutic effect discussed in recent scientific works. The purpose of this review of the literature is to expand the understanding of bilirubin from the clinician’s usual in the context of the end product of heme and antioxidant metabolism to a signaling molecule involved in the pathophysiology of many diseases.

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Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals

Cited by 6 publications

References 69 publications

Serum Bilirubin Level Is Increased in Metabolically Healthy Obesity

Serum Bilirubin Level Is Increased in Metabolically Healthy Obesity

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Gilbert’s syndrome as a model for studying the effects of bilirubin

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