Serum magnesium in pregnancy induced hypertension

Bandebuche, Sanjyoti; Sagade, Bhushan; Sontakke, Alka N.

doi:10.5455/2320-6012.ijrms20131119

Cited by 6 publications

(7 citation statements)

References 12 publications

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“…The present study also found that women with preeclampsia had a significantly higher mean serum calcium-magnesium ratio than did women without preeclampsia (1.94±0.957 vs 2.54±0.775; P =0.0001). This finding agrees with a study conducted by Bandebuche et al that showed the mean ratio of calcium-magnesium in the preeclampsia group was lower than that of the non-preeclampsia group [ 28 ].…”

Section: Discussionsupporting

confidence: 93%

“…Nahar et al reported that the estimation of serum magnesium during the antenatal period can help predict preeclampsia and prevent eclampsia [ 26 , 27 ]. Three studies, conducted in 2013, 2018, and 2019, showed that mean calcium levels in patients with preeclampsia were significantly higher than those in patients without preeclampsia [ 28 – 30 ]. There are also some studies that reported no significant differences in serum magnesium levels between women with and without preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

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Ratio of Serum Calcium to Magnesium Levels on Pregnancy With and Without Preeclampsia

et al. 2021

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Background Preeclampsia increases maternal and perinatal mortality and is affected by calcium and magnesium levels. Reduced extracellular levels of calcium and magnesium constitute the pathogenesis of eclampsia. A reduction in the calcium-magnesium ratio may aid in the detection and prevention of preeclampsia. Material/Methods This was an analytical observational study with a cross-sectional design, including patients with and without preeclampsia (inpatient and outpatient). A total of 246 patients were included in this research; 138 patients had preeclampsia and 108 patients did not. All examinations of magnesium and calcium levels at the Hasan Sadikin Hospital Clinical Pathology laboratory were conducted using an ion selective electrode modified with methylthymol blue complexometric titration. Results Patients with preeclampsia had significantly higher average serum magnesium and calcium levels than did patients without preeclampsia (2.85 vs 2.09, P =0.0001; 4.45 vs 4.85, P =0.025, respectively). Patients with preeclampsia demonstrated significantly lower serum calcium-magnesium ratios than did patients without preeclampsia (1.98 vs 2.60, P =0.0001). Receiver operating characteristic curve analysis on the serum calcium-magnesium ratio showed an area under the curve of 68.0% ( P =0.0001), with a cutoff value of 2.36 (sensitivity 64.8%, specificity 62.3%), indicating that patients with serum calcium-magnesium ratios of <2.36 were predicted to have a risk of preeclampsia. Conclusions Patients with preeclampsia had significantly lower serum calcium-magnesium ratios than did patients without preeclampsia; therefore, a low calcium-magnesium ratio could be a risk factor for preeclampsia.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Ratio of Serum Calcium to Magnesium Levels on Pregnancy With and Without Preeclampsia

et al. 2021

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“…Abruption due to gestational hypertension was seen in 10% and 21% of cases among the local and regional populations, respectively [ 1 , 7 , 9 ]. The risk of abruption placenta was also found to be 2.4 times among women with chronic hypertension and not surprisingly increased further in the presence of preeclampsia or fetal growth retardation [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pregnancy-induced hypertension (PIH) is the onset of new arterial hypertension in a pregnant woman after the 20th week of gestation, during labour or puerperium in previously normotensive women without the presence of protein in the urine [ 1 , 2 ]. It occurs in about 6-8% of all pregnancies [ 1 , 3 ]. The incidence of PIH varies throughout the world; however, the incidence is higher in developing countries [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Frequency of Abruptio Placenta in Women With Pregnancy-Induced Hypertension

Khan¹,

Chughani²,

Amir³

et al. 2022

Cureus

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Background: Bleeding that takes place after premature separation of the normally situated placenta, usually after 20 weeks of pregnancy, is known as abruptio placenta. Factors increasing chances of abruptio placenta are advanced age pregnancy, parity, smoking, pregnancy-induced hypertension, pre-eclampsia, and previous incidence of abruptio. The objective of the study was to find the frequency of abruptio placenta in women with pregnancy-induced hypertension. Methods: This descriptive prospective study was conducted in the Department of Obstetrics and Gynaecology, Jinnah Postgraduate Medical Centre, Karachi, from January to July, 2021. Women of gestational age above 20 weeks were included. Patients with blood pressure ≥140/90mmHg were considered as having pregnancy-induced hypertension. Early separation of the normally placed placental from the uterine wall was defined as placental abruption with clinical signs of painful vaginal bleeding (concealed or revealed), uterine contractions, and non-reassuring fetal heart rate. Descriptive statistics were calculated. Stratification was done and the post-stratification chi-square test was applied. P-value ≤ 0.05 was taken as significant. Results: A total of 205 patients were included in the study. The mean age was 24.26±2.92 years. The mean gestational age was 30.82±3.22 weeks. The mean parity was 2.59±0.80 children. Mean systolic blood pressure was 148.48±5.99 mmHg and mean diastolic blood pressure was 94.85±3.05 mmHg. Bleeding was reported in 110 (53.7%) cases. Lower abdominal tenderness in 125 (60.5%) cases. Fetal heart rate was normal in 16.6% of the cases. Abruptio placenta was observed in 29 (14.1%) patients. Conclusion:Abruptio placenta is a life-threatening condition that occurs during pregnancy that can result in both maternal and fetal morbidity and mortality. Adequate and urgent intervention can result in a favourable outcome.

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“…16 Serum magnesium progressively declines during pregnancy reaching a nadir at 34 weeks and then rises up to term. 17 Statistically significant fall in serum magnesium has been observed in pre-eclampsia and with remarkable reduction in eclampsia. 18 In study done by Indumathi V et al, serum magnesium decreased in the study group when compared to control group which was significant.…”

Section: Serum Magnesiummentioning

confidence: 98%

Study of serum lipid profile and magnesium in preeclampsia

Reddy

Vineela

Chowdary

2019

Int J Reprod Contracept Obstet Gynecol

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Background: A comparative study of serum lipid profile and magnesium levels in normal pregnancy versus preeclampsia (PE).Methods: A prospective study done for 2 years (October 2014 to October 2016) in the Department of Obstetrics and Gynecology, Narayana medical college and hospital, a tertiary care centre, Nellore, Andhra Pradesh, India. A sample size of 200 pregnant women, recruited and divided into group A and B. group A being women with PE and group B is normal pregnant women.A10ml of venous blood was collected in the fasting state and serum collected from clotted blood to measure lipid profile, magnesium, Apo lipoprotein A-I and Apo lipoprotein B 100.Serum Lipid profile measured by enzymatic method using commercially available kit Human (GmbH Germany) using humastar 600 chemistry analyzer (Human GmbH Germany). Serum magnesium measured by dye binding method using commercially available kit Human (GmbH Germany) using Humastar 600 chemistry analyzer (Human GmbH Germany). Serum ApoA-I and ApoB were measured by immune-turbidometry using commercial kits from Spinreact Spain. Urine albumin done by dipstick method.Results: Serum total cholesterol (TC), Triglyceride (TG), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), Apo lipoprotein B 100 (Apo B100) were high and serum Magnesium, high density lipoprotein (HDL) and Apo lipoprotein A1(Apo A1) were low in the study group (group A) compared to controls (group B).Conclusions: Abnormal lipid profile (low HDL and increased TG concentration) and serum hypomagnesaemia may be contributing etiologies of preeclampsia, having good predictive value as a screening procedure for PE in high risk pregnant population.

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Serum magnesium in pregnancy induced hypertension

Cited by 6 publications

References 12 publications

Ratio of Serum Calcium to Magnesium Levels on Pregnancy With and Without Preeclampsia

Ratio of Serum Calcium to Magnesium Levels on Pregnancy With and Without Preeclampsia

Frequency of Abruptio Placenta in Women With Pregnancy-Induced Hypertension

Study of serum lipid profile and magnesium in preeclampsia

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