Background: Bleeding that takes place after premature separation of the normally situated placenta, usually after 20 weeks of pregnancy, is known as abruptio placenta. Factors increasing chances of abruptio placenta are advanced age pregnancy, parity, smoking, pregnancy-induced hypertension, pre-eclampsia, and previous incidence of abruptio. The objective of the study was to find the frequency of abruptio placenta in women with pregnancy-induced hypertension. Methods: This descriptive prospective study was conducted in the Department of Obstetrics and Gynaecology, Jinnah Postgraduate Medical Centre, Karachi, from January to July, 2021. Women of gestational age above 20 weeks were included. Patients with blood pressure ≥140/90mmHg were considered as having pregnancy-induced hypertension. Early separation of the normally placed placental from the uterine wall was defined as placental abruption with clinical signs of painful vaginal bleeding (concealed or revealed), uterine contractions, and non-reassuring fetal heart rate. Descriptive statistics were calculated. Stratification was done and the post-stratification chi-square test was applied. P-value ≤ 0.05 was taken as significant. Results: A total of 205 patients were included in the study. The mean age was 24.26±2.92 years. The mean gestational age was 30.82±3.22 weeks. The mean parity was 2.59±0.80 children. Mean systolic blood pressure was 148.48±5.99 mmHg and mean diastolic blood pressure was 94.85±3.05 mmHg. Bleeding was reported in 110 (53.7%) cases. Lower abdominal tenderness in 125 (60.5%) cases. Fetal heart rate was normal in 16.6% of the cases. Abruptio placenta was observed in 29 (14.1%) patients. Conclusion:Abruptio placenta is a life-threatening condition that occurs during pregnancy that can result in both maternal and fetal morbidity and mortality. Adequate and urgent intervention can result in a favourable outcome.

Objective: To determine the association of Metabolic Disorders in women of reproductive age with polycystic ovarian syndrome (PCOS) Study Design and setting: Cross Sectional Study conducted in the Department of Gynecology and Obstetrics, Ward 9, Jinnah Postgraduate Medical Center, Karachi. Methodology: The study was conducted from November 2021 to February 2022. A total of 227 diagnosed patients of PCOS were included in this study. Five components of Metabolic syndrome were assessed: Body Mass Index (BMI), blood pressure, central obesity, fasting blood sugar and lipid profile. Informed consent was obtained from all participants. Patients’ history, physical examination and laboratory investigations in terms of symptoms and findings relating to MS were recorded and assessed using SPSS version 21. Descriptive statistics were calculated and stratification was done. Chi-square test used post stratification and p-value =0.05 were considered significant. Results: Mean age was 27.05±4.51 years. Mean symptom duration was 11.26±3.02 months. Central obesity, hypertension, hypertriglyceridemia, HDL-cholesterol <50 mg/dl and fasting glucose >100 mg/dl were found in 44.9%, 31.7%, 38.3%, 27.3%, and 38.8% patients, respectively. A total of 47 (20.7%) study subjects were identified with two or more above components of MS. Significant association of MS with age (>27 years; p<0.000) and duration of disease (>12 months; p<0.000) was observed. Conclusion: A higher prevalence of MS was observed when participants aged more than 27 years and had symptoms for more than a year. Higher BMI was also found nearing statistical significance