Serum macrophage-colony stimulating factor levels in colorectal cancer patients correlate with lymph node metastasis and poor prognosis

Mroczko, Barbara; Groblewska, Magdalena; Wereszczyńska-Siemiątkowska, Urszula; Okulczyk, Bogna; Kędra, Bogusław; Laszewicz, W; Dâbrowski, A; Szmitkowski, Maciej

doi:10.1016/j.cca.2007.02.037

Cited by 94 publications

(71 citation statements)

References 18 publications

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“…The serum levels of both macrophage-colony stimulating factor (M-CSF) and granulocyte-colony stimulating factor are significantly higher in CRC patients than in healthy subjects (55,56). In addition, serum levels of M-CSF are more associated with lymph node metastasis than CEA and CA 19-9, which suggests that serum M-CSF elevation in CRC patients might help predict the risk of lymph node metastasis of this tumor.…”

Section: Macrophage-colony Stimulating Factormentioning

confidence: 88%

Noninvasive molecular biomarkers for the detection of colorectal cancer

Kim¹,

Yu²,

Kim³

et al. 2008

BMB Reports

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Colorectal cancer (CRC) is the third most common malignancy in the world. Because CRC develops slowly from removable precancerous lesions, detection of the disease at an early stage during regular health examinations can reduce both the incidence and mortality of the disease. Although sigmoidoscopy offers significant improvements in the detection rate of CRC, its diagnostic value is limited by its high costs and inconvenience. Therefore, there is a compelling need for the identification of noninvasive biomarkers that can enable earlier detection of CRC. Accordingly, many validation studies have been conducted to evaluate genetic, epigenetic or protein markers that can be detected in the stool or in serum. Currently, the fecal-occult blood test is the most widely used method of screening for CRC. However, advances in genomics and proteomics combined with developments in other relevant fields will lead to the discovery of novel non invasive biomarkers whose usefulness will be tested in larger validation studies. Here, noninvasive molecular biomarkers that are currently used in clinical settings and have the potential for use as CRC biomarkers are discussed. [BMB reports 2008; 41(10): 685-692]

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Section: Macrophage-colony Stimulating Factormentioning

confidence: 88%

Noninvasive molecular biomarkers for the detection of colorectal cancer

Kim¹,

Yu²,

Kim³

et al. 2008

BMB Reports

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“…Our knowledge about correlation between white blood cells count before surgery and prognosis of malignancy is incomplete. In one study about gastric cancer it was shown that preoperational absolute granulocyte count less than 6000 in mm3, lymphocyte count higher than 1500 in mm3 and monocyte count between 3000-9000 are the independent factors for poor prognosis and other studies were shown leukocytosis is associated with poor prognosis in lung cancer, colon cancer, endometrial cancer and cervical cancer [20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Association between Preoperational Blood Profiles and Post Operational Complications in Patients Suffering Epithelial Ovarian Cancer

Nasiri¹

2017

MOJWH

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Anemia, leukocytosis, thrombocytosis and other para neo plastic disorders have been seen in numerous malignancies especially in advanced stages. We studied the preoperational leukocytosis and thrombocytosis and clinical outcomes in patients with epithelial ovarian cancer. This study was carried out as a prospective cohort at the gynecology oncology department of Valiasr ward of Imam Hospital of Tehran university of Iran. The blood cells profile, post operational complications and overall survival have been investigated. The demographic characteristic and information concerning to specifications of ovarian cancer histopathologically, count of preoperational blood cells, post operational complications occurring after 30 days of surgery, recurrence and metastasize of disease during a year after surgery were investigated. Preoperational leukocytosis was associated with higher stage and grade and superficial and deep wound infections. Preoperational leukocytosis was associated with higher mortality rate and lower overall survival too. Further studies must pay attention to association between blood cells parameters and prediction of response to treatment option selected in epithelial ovarian cancer for choosing patients who are most profits of neo adjuvant chemotherapy.

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“…Tumor cells secrete a large amount of CSF1 (Lin et al, 2001), leading to recruitment of macrophages in the tumor regions. High expression levels of CSF1 have been shown to correlate with poor prognosis in various cancers Mroczko et al, 2007;Zhu et al, 2008). CSF1-CSF1R inhibition is effective in reducing the number of macrophages in a mouse gastrointestinal stromal tumors model (Cohen et al, 2013) and enhances the antitumor effects of VEGF-targeted therapies (Priceman et al, 2010).…”

Section: Involvement Of Macrophages In Tumor Developmentmentioning

confidence: 99%

Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation

Ohashi

Hattori

2015

J Pharmacol Exp Ther

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Macrophages are a well recognized player of both innate and adaptive immunity and have emerged as a key regulator of systemic metabolism, hematopoiesis, vasculogenesis, apoptosis, malignancy, and reproduction. Such pleiotropic roles of macrophages are mirrored by their protean features. Upon environmental. challenges, macrophages redistribute and differentiate in situ and contribute to the multiple disease states by exerting protective and pathogenic effects. The environmental challenges include cytokines, chemokines, lipid mediators, and extrinsic insults, such as food and pathogenic bacteria. In addition, homeostasis and the activation state of macrophages are influenced by various metabolites from a commensal microbe that colonizes epithelial and mucosal surfaces, such as the lungs, intestines, and skin. In this review, we describe macrophage differentiation, polarization, and various functions in chronic disease states, including chronic inflammatory bowel disease, tumorigenesis, metabolism and obesity, and central nervous system demyelinating disorders. Controlling the macrophage dynamics to affect the pathologic states is considered to be an important therapeutic approach for many clinical disorders involving chronic inflammation.

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Serum macrophage-colony stimulating factor levels in colorectal cancer patients correlate with lymph node metastasis and poor prognosis

Cited by 94 publications

References 18 publications

Noninvasive molecular biomarkers for the detection of colorectal cancer

Noninvasive molecular biomarkers for the detection of colorectal cancer

Association between Preoperational Blood Profiles and Post Operational Complications in Patients Suffering Epithelial Ovarian Cancer

Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation

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