Serum Mac‐2 binding protein glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation

Yamada, Naoya; Katano, Takumi; Hirata, Yuta; Okada, Noriki; Sanada, Yukihiro; Ihara, Yoshiyuki; Urahashi, Taizen; Ushijima, Kazuo; Karasawa, Tadayoshi; Takahashi, Masafumi; Mizuta, Koichi

doi:10.1111/jgh.14438

Cited by 15 publications

(12 citation statements)

References 25 publications

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“…M2BPGi increased in stages, as graft liver fibrosis progressed to a high degree. Further, in children, a correlation between post‐transplant liver fibrosis and M2BPGi has been reported by Yamada et al 21 The AUROC for diagnosis of F ≥ 2 in M2BPGi was 0.778, which was superior to Fibroscan and Fib‐4 index (Table 2). Therefore, the diagnostic performance of M2BPGi was comparable to other non‐invasive markers.…”

Section: Discussionmentioning

confidence: 54%

“…M2BPGi level was higher in the additional biopsy subgroup compared with the protocol‐biopsy subgroup ( P < .012). Previous reports have shown that M2BPGi level may be affected by inflammation 26 and post‐LT rejection is associated with M2BPGi 21 . Therefore, when considering rejection or under special circumstances, a biopsy may be more informative.…”

Section: Discussionmentioning

confidence: 99%

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Serum Mac‐2 binding protein glycosylation isomer as a biomarker of fibrosis in living donor liver transplant graft

Sasaki

Miyaaki

Narita

et al. 2020

Clinical Transplantation

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Introduction Non‐invasive assessment of graft fibrosis is important in liver transplantation. Mac‐2 binding protein glycosylation isomer (M2BPGi) has been reported as a diagnostic marker for this purpose, and thus, this predictive ability of M2BPGi was assessed in this study. Patients and methods In this retrospective study, 236 patients who received living donor liver transplantation (LDLT) from August 1997 to March 2017 were enrolled. Among them, 94 biopsy patients were analyzed. Further, the predictive ability of fibrotic biopsy using M2BPGi, Fibroscan, and Fib‐4 index was compared. Results Of 94 LDLT patients (53 men, 41 women), the median ages of recipients and donors were 57.5 and 33.0 years, respectively. The median M2BPGi values in patients with F0 (n = 11), F1 (n = 38), F2 (n = 35), and F3/4 (n = 10) were 0.680, 0.760, 1.240, and 4.110 COI, respectively. There were significant correlations between the fibrotic stage and M2BPGi levels (Kruskal‐Wallis test, P < .0001). The area under the ROC curve for the diagnosis of F ≥ 2 in M2BPGi was 0.778, which was superior to Fibroscan (0.701) and Fib‐4 index (0.639). Conclusion M2BPGi is an accurate, non‐invasive detection method for significant fibrosis after LDLT.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Serum Mac‐2 binding protein glycosylation isomer as a biomarker of fibrosis in living donor liver transplant graft

Sasaki

Miyaaki

Narita

et al. 2020

Clinical Transplantation

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“…However, our study was more extensive, as we included more publications, had different subgroup setups, and used different models for the calculation of pooled results. WFA+-M2BP has the potential to reflect hepatic fibrosis as hepatic stellate cells (HSCs) are the source of WFA+-M2BP and its level is closely associated with α-smooth-muscle actin (αSMA) expression 19,21 . However, HBV-positive patients are more likely to experience quiescent hepatic inflammation, and HBV-related cirrhosis had large regenerative nodules and thin fibrous septa 23,27 .…”

Section: Discussionmentioning

confidence: 99%

“…In liver, WFA+-M2BP could promote fibrogenesis by acting as an important messenger between HSCs (secrete WFA+-M2BP) and Kupffer cells (express the ligand of M2BP, Mac-2) 18,19 . Additionally, WFA+-M2BP could be increased by TGF-β1 in LX-2 cell and it correlates with serum IP-10 and sICAM-1 levels in patients with AIH 20,21 . Those evidences suggested serum WFA+-M2BP has a great potential to serve as a biomarker for reflecting the liver status of CLD patients 16,22 .…”

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confidence: 91%

Wisteria floribunda agglutinin-positive Mac-2-binding protein as a diagnostic biomarker in liver cirrhosis: an updated meta-analysis

Feng

Wang

Zhao

et al. 2020

Sci Rep

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Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+-M2BP) had been suggested as a possible glycobiomarker for assessing liver fibrosis. Here, we conducted this updated metaanalysis to systematically investigate the predictive accuracy of WFA+-M2BP for diagnosing liver fibrosis and hepatocellular carcinoma (HCC) by comparing with multiple non-invasive indicators. We searched relevant literatures from Pubmed, Web of Science, EMBASE and Cochrane Library and enrolled 36 eligible studies involving 7,362 patients. Summary results were calculated using bivariate random effects model. The pooled sensitivities, specificities and areas under the summary receiver operating characteristic curves (AUSROCs) of WFA+-M2BP for identifying mild fibrosis, significant fibrosis, advanced fibrosis, cirrhosis, and HCC were 0.

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“…Activated HSCs in these situations may have a high potential to secrete M2BPGi. Indeed, it was reported that M2BPGi was increased in liver transplant patients with acute cellular rejection, even when fibrosis was absent . Furthermore, Morio et al reported that serum M2BPGi values were associated with clinical outcomes such as acute liver failure, development of hepatic coma, liver transplant, and death, suggesting that M2BPGi might reflect the severity of liver injury.…”

Section: Discussionmentioning

confidence: 99%

Elevation of Mac‐2 binding protein glycosylation isomer after hepatectomy is associated with post‐hepatectomy liver failure, total Pringle time, and renal dysfunction

Imai

Maeda

Wang

et al. 2019

Annals of Gastroent Surgery

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Background Mac‐2 binding protein glycosylation isomer (M2BPGi) is a novel serum glycomarker used to assess liver fibrosis. However, it has been reported that M2BPGi is likely to reflect other factors not limited to liver fibrosis. Methods We retrospectively analyzed 79 patients with liver tumors who underwent liver resection. M2BPGi was measured within 1 week before operation and almost 1 month after operation. We introduced a value termed the “ΔM2BPGi ratio” (=M2BPGiafter operation/M2BPGibefore operation), and analyzed factors that influenced the ΔM2BPGi ratio. Results The median value of the ΔM2BPGi ratio was 1.28 (range, 0.36‐5.68). In 64 patients (81.0%), the cutoff index values of M2BPGi were elevated approximately 1 month after operation, especially in patients who experienced post‐hepatectomy liver failure (PHLF). Multiple linear regression showed total Pringle time, PHLF grade ≥B, and preoperative value of creatinine were significant predictors of the ΔM2BPGi ratio. The mean values of the ΔM2BPGi ratio were 1.37 ± 0.07, 1.52 ± 0.22, and 2.94 ± 0.30 for PHLF grade 0, grade A, and grade B, respectively, resulting in statistically significant differences by the Kruskal‐Wallis test (P = 0.022). Conclusions Total Pringle time, PHLF grade ≥B, and preoperative creatinine significantly influenced the elevation of M2BPGi almost 1 month after liver resection. This study strongly affirms the previous suggestion that M2BPGi is likely to reflect other factors not limited to liver fibrosis.

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Serum Mac‐2 binding protein glycosylation isomer predicts the activation of hepatic stellate cells after liver transplantation

Abstract: Mac-2 binding protein glycosylation isomer is a novel liver fibrosis marker in LT recipients and is also increased in patients with acute liver injuries, especially acute cellular rejection, even when fibrosis is absent.

Cited by 15 publications

References 25 publications

Serum Mac‐2 binding protein glycosylation isomer as a biomarker of fibrosis in living donor liver transplant graft

Serum Mac‐2 binding protein glycosylation isomer as a biomarker of fibrosis in living donor liver transplant graft

Wisteria floribunda agglutinin-positive Mac-2-binding protein as a diagnostic biomarker in liver cirrhosis: an updated meta-analysis

Elevation of Mac‐2 binding protein glycosylation isomer after hepatectomy is associated with post‐hepatectomy liver failure, total Pringle time, and renal dysfunction

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