Serum Lipoproteins and Cholesterol Metabolism in Xanthelasma

Epstein, Norman N.; Rosenman, Ray H.; Gofman, John W.

doi:10.1001/archderm.1952.01530200074011

Cited by 35 publications

(6 citation statements)

References 22 publications

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“…1). This is in concordance with previous studies by Sankar SP, Samuel P, Jain et al, Gangopadadhya et al, Epstein et al and Pedace et al [6][7][8][9][10] Cosmetic concern might be a reason for female preponderance in OPD.…”

Section: Resultssupporting

confidence: 93%

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

2020

IJN

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Introduction: Xanthelasma palpebrum (XP) is a disorder of lipid metabolism that usually presents as bilateral and symmetrical, soft velvety papules and plaques around the eyelids. Though various factors contribute to its etiology, a strong association with lipid metabolism is proposed. Usually seen in middle age people, its main concern is cosmetic appearance. Objective: 1. To evaluate the lipid profile, glycemic levels, Body Mass Index (BMI) in patients with Xanthelasma palpebrum. 2. To find the association between parameters like age, sex and comorbid illness with Xanthelasma palpebrum. Materials and Methods: This prospective study included 42 clinically diagnosed patients with Xanthelasma Palpebrarum and 95 subjects in control group with non-inflammatory skin disorders. Levels of serum triglyceride, cholesterol, HDL, LDL, VLDL, blood sugar -fasting and post prandial were determined in all cases along with body mass index and blood pressure. These parameters were compared in both groups and association with XP was analysed. Results and Discussion: In our study, XP was more common in females compared to males. In our study of patients with XP, average fasting blood sugar was 108 gm% and average post prandial blood sugar was 152gm%. Average serum triglyceride levels in patients with XP was 171.4 mg/dl, compared to 108.4 mg/dl in control group with significant p value i.e. 0.001, suggesting strong correlation between XP and serum triglyceride levels. Conclusion: Patients with XP usually visit doctor with cosmetic concern. In most of the cases of XP, serum cholesterol, triglyceride and VLDL levels are deranged. Patients with XP should be evaluated for above parameters and systemic management done along with treatment of XP.

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Section: Resultssupporting

confidence: 93%

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

2020

IJN

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“…Epstein et al . 9 and Pedace and Winkelmann 10 found rates of CVD of 15% and 30%, respectively, in patients with xanthelasma. Watanabe et al .…”

Section: Discussionmentioning

confidence: 95%

“…demonstrated an association between xanthelasma and atherosclerotic heart disease in 69% of cases. Epstein et al 9 . and Pedace and Winkelmann 10 found rates of CVD of 15% and 30%, respectively, in patients with xanthelasma.…”

Section: Discussionmentioning

confidence: 96%

Xanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a)

2008

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“…2 Although xanthelasma is a type of xanthoma, 25%-70% (on average, 50%) of patients in most series are normolipidemic (defined initially as those with normal cholesterol and triglyceride levels). [3][4][5][6][7][8][9][10][11][12] The main lipid that is stored in both hyperlipidemic and normolipidemic xanthelasmas is cholesterol; [13][14][15] as in most other hypercholesterolemic xanthomas, 16,17 the major portion of the cholesterol is esterified. [13][14][15] There is some similarity between cholesterol-accumulating xanthomas and atheroma formation, at least experimentally.…”

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confidence: 99%

Xanthelasma palpebrarum and risk of atherosclerosis

Bergman

1998

Int J Dermatology

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Serum Lipoproteins and Cholesterol Metabolism in Xanthelasma

Cited by 35 publications

References 22 publications

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

Neurotization in brachial plexus injury â€“ A 3 year experience in tertiary government institution

Xanthelasma palpebrarum and its relation to atherosclerotic risk factors and lipoprotein (a)

Xanthelasma palpebrarum and risk of atherosclerosis

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