Serum lipoprotein pattern of the hypercholesteremic gerbil

Gordon, Samuel; Cekleniak, Walter P.

doi:10.1152/ajplegacy.1961.201.1.27

Cited by 22 publications

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“…Cholesterol metabolism of the gerbil is similar to that of humans, so this species has been used to study the effects of dietary cholesterol and fats (Gordon and Cekleniak, 1961). Gerbils fed a diet with no cholesterol have higher alpha lipoprotein fractions than pre-beta or beta lipoprotein fractions (Forsythe, 1986).…”

Section: )mentioning

confidence: 99%

Clinical Biochemistry and Hematology

Washington

Hoosier

2012

The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents

113

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Section: )mentioning

confidence: 99%

Clinical Biochemistry and Hematology

Washington

Hoosier

2012

The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents

113

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“…Mongolian gerbils, Meriones unguiculatus , are rodents belonging to the subfamily Gerbillinae. Gerbils are widely used as research models in areas such as aging [ 48 ], metabolism [ 49 , 50 , 51 , 52 , 53 , 54 ], anatomy [ 55 , 56 ], and parasitic diseases [ 57 , 58 ]. In neuroscience research, gerbils have been widely used to study sensory systems [ 59 , 60 , 61 , 62 , 63 ], neural diseases [ 61 , 64 , 65 , 66 ], and brain structure [ 67 , 68 , 69 ].…”

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confidence: 99%

The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil

et al. 2022

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Somatostatin (SST) is widely expressed in the brain and plays various, vital roles involved in neuromodulation. The purpose of this study is to characterize the organization of SST neurons in the Mongolian gerbil visual cortex (VC) using immunocytochemistry, quantitative analysis, and confocal microscopy. As a diurnal animal, the Mongolian gerbil provides us with a different perspective to other commonly used nocturnal rodent models. In this study, SST neurons were located in all layers of the VC except in layer I; they were most common in layer V. Most SST neurons were multipolar round/oval or stellate cells. No pyramidal neurons were found. Moreover, 2-color immunofluorescence revealed that only 33.50%, 24.05%, 16.73%, 0%, and 64.57% of SST neurons contained gamma-aminobutyric acid, calbindin-D28K, calretinin, parvalbumin, and calcium/calmodulin-dependent protein kinase II, respectively. In contrast, neuropeptide Y and nitric oxide synthase were abundantly expressed, with 80.07% and 75.41% in SST neurons, respectively. Our immunocytochemical analyses of SST with D1 and D2 dopamine receptors and choline acetyltransferase, α7 and β2 nicotinic acetylcholine receptors suggest that dopaminergic and cholinergic fibers contact some SST neurons. The results showed some distinguishable features of SST neurons and provided some insight into their afferent circuitry in the gerbil VC. These findings may support future studies investigating the role of SST neurons in visual processing.

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“…On the other hand, gerbils are more sensitive to dietary cholesterol than man. They do not develop atherosclerosis (Gordon & Cekleniak, 1961) but a diet containing 2 g cholesterol/kg causes severe hypercholesterolaemia and high levels of cholesteryl esters in the liver, ultimately leading to cirrhosis (Temmerman et al 1988). In rats, 5-10 g cholesterol/kg diet, and often also bile acids, must be added to produce elevated blood cholesterol levels (Shinnick et al In the present study we fed gerbils on diets containing 1 g cholesterol/kg and 40 % of the energy from fat, i.e.…”

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Effect of oat saponins on plasma and liver lipids in gerbils (Meriones unguiculatus) and rats

Önning

Asp

1995

Br J Nutr

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The effects of oat saponins (a mixture of avenaddes A and B) on plasma and liver lipids in gerbils (Merimes unguicrrlatrrJ) and rats were investigated. Cholesterolantaining diets high in total and saturated fat and with Merent avenacoside contents (zero (ethanol-extracted oats), normal (oats) and twice normal (ethanokxtracted oats plus added avenaddes)) were used. Compared wilh a celldose control group the oat diets in both species gave a aigdicantly higher cholesterol content in the HDL fraction and a signi6cantly lower liver cholesterol content. No signi6cant differences in total plasma cholesterol, HDGcbolesterol and plasma triacylglycerols were found, however, between the groups fed on oats with different avenacoside content. The liver weight, total liver cholesterol and free liver cholesterol were also similar, whereas the liver lipid content was significantly lower in rats given the highest amount of avenacosides compared with zero or normal amounts. The tendency was the same in gerbils. Thus, the oat saponins had only minor effects on lipid metabolism in gerbils and rats.Gerbil: Lipid metabolism: Oats: Saponins

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Serum lipoprotein pattern of the hypercholesteremic gerbil

Cited by 22 publications

References 0 publications

Clinical Biochemistry and Hematology

Clinical Biochemistry and Hematology

The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil

Effect of oat saponins on plasma and liver lipids in gerbils (Meriones unguiculatus) and rats

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