Serum lipids level assessed in early pregnancy and risk of pre‐eclampsia

Demirci, Oya; Tuğrul, Ahmet Semih; Dolgun, Nihal; Sözen, Hamdullah; Eren, Sadiye

doi:10.1111/j.1447-0756.2011.01562.x

Cited by 30 publications

(25 citation statements)

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“…Increased glycerol was detected in the women with PE, similar to the Bahado-Singh study [26], where it was attributed to abnormal lipid metabolism as it forms the backbone of triglycerides. The lipoprotein profiles here shown related to PE are similar to those found for people at risk of CVD [28], with increased low density lipoprotein levels. Lipid dysfunction starts early in pregnancies destined for PE development [28], suggesting that metabolomics may be used to predict the onset of PE.…”

Section: Discussionsupporting

confidence: 75%

Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia

et al. 2014

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ObjectiveTo explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis.MethodsUrine and serum samples from pregnant women with preeclampsia (n = 10), normal pregnancies (n = 10) and non-pregnant women (n = 10) matched by age and gestational age were analyzed with MR spectroscopy and subjected to multivariate analysis. Metabolites were then quantified and compared between groups.ResultsUrine and serum samples revealed clear differences between women with preeclampsia and both control groups (normal pregnant and non-pregnant women). Nine urine metabolites were significantly different between preeclampsia and the normal pregnant group. Urine samples from women with early onset preeclampsia clustered together in the multivariate analysis. The preeclampsia serum spectra showed higher levels of low and very-low density lipoproteins and lower levels of high-density lipoproteins when compared to both non-pregnant and normal pregnant women.ConclusionThe MR determined metabolic profiles in urine and serum from women with preeclampsia are clearly different from normal pregnant women. The observed differences represent a potential to examine mechanisms underlying different preeclampsia phenotypes in urine and serum samples in larger studies. In addition, similarities between preeclampsia and cardiovascular disease in metabolomics are demonstrated.

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Section: Discussionsupporting

confidence: 75%

Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia

et al. 2014

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“…Clinical studies have found that patients with preeclampsia, especially early-onset preeclampsia, had existing abnormal lipid metabolism, involving FFAs [20], triglycerides [21,22], cholesterol [23], low-density lipoprotein [24] and phospholipids [25]. FFAs are not only used as mitochondrial substrates for FAO to supply energy, they also have a role in oxidative stress and inflammatory signalling pathways; this role has had much attention during research into the pathogenesis of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial Long Chain Fatty Acid Oxidation Related Enzyme Changes in Different Preeclampsia-Like Mouse Models

Ding¹,

Yang²

2013

J Hypertens

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IntroductionPreeclampsia is a serious obstetric complication and a major cause of maternal and perinatal mortality and its pathogenesis is still unclear. We and other researchers have proven that long-chain Fatty Acid Oxidation (FAO) is associated with some forms of preeclampsia.Most fatty acids in the human body are long-chain fatty acids. The β-oxidation of fatty acids occurs in the mitochondria. After activation of long-chain fatty acids, they need assistance from carnitine as a carrier and catalysis of carnitine palmitoyltransferase I (CPT I) in the outer mitochondrial membrane and carnitine palmitoyltransferase II (CPT II) in the inner mitochondrial membrane to enter into the mitochondria [1]. Long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) is a component of the mitochondrial trifunctional protein and is capable of catalyzing the third step of β-oxidation [2]. So CPT I, CPT II and LCHAD are key enzymes in the long-chain FAO process, and defects or dysfunction of which can result in disorders in longchain fatty acid transport into the mitochondria or oxidation, further resulting in inefficient energy release from FAO and affecting cell function.In a normal pregnancy, prolactin and estrogen increase the activity of hormone sensitive lipase, resulting in increased fat mobilization, increased maternal plasma Free Fatty Acids (FFA) and increased hepatic uptake of fatty acids. In the past, FAO was generally considered unimportant in placental and fetal development; however, a recent study found that this was not the case. Shekhawat et al. found that LCHAD and six other fatty acid β-oxidation enzymes were abundantly expressed in the placenta, indicating the long-chain FAO played an important role in placental development and energy supply [3]. Oey et al. found Very Long Chain Acyl-Coenzyme a Dehydrogenase (VLCAD) and LCHAD mRNA highly expressed during different stages in the embryo and fetal heart, liver and other tissues, and there were strong VLCAD, LCHAD and CPT II enzyme activities [4]. So long-chain FAO exists not only in the placenta, but also in embryonic tissues, and plays an important role in early development of the fetus. Thus, in a normal pregnancy placental and fetal development also requires FAO as an energy supply.Previous studies have found that LCHAD was associated with some forms of preeclampsia. Bartha and colleagues reported that LCHAD mRNA expression decreased in the placenta of preeclampsia patients compared with controls, and that the FAO ability of the placenta in preeclampsia patients was reduced [5]. Robinson et al. found that the plasma of preeclampsia patients could lead to lipid droplet aggregation in cultured human umbilical vein endothelial cells and decreased mitochondrial dehydrogenase activity [6]. In our previous studies we also found LCHAD expression decreased in the placenta with earlyonset severe preeclampsia, but there was no significant difference between late-onset preeclampsia and the control groups [7]. In animal experiments, we found that LCHAD expression was signifi...

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“…De la dislipidemia observada en el embarazo, la hipertrigliceridemia se ha descrito como parte de la etiopatogenia y como predictor del riesgo de preeclampsia 13,15,[20][21][22][23] . En este sentido, aunque los triglicéridos pueden estar elevados en las gestaciones normales, un incremento excesivo puede conducir a un entorno oxidativo con lesión endotelial y desarrollo consiguiente de preeclampsia 18 .…”

Section: Figuraunclassified

“…Es de destacar que la asociación de triglicéridos elevados (> 181 mg/dl) y concentraciones elevadas de LDL oxidado aumentaban el riesgo de preeclampsia en casi 9 veces (OR: 8,9; IC 95%: 3,1-26,2) 21 . Si bien en la mayoría de estos estudios las muestras sanguíneas se obtuvieron en el tercer trimestre del embarazo, también se han encontrado concentraciones de triglicéridos superiores en la preeclampsia, cuando estas se determinan antes de las 20 semanas de gestación 18,23,24 .…”

Section: Figuraunclassified

“…Tan solo un estudio en el que se analizaron 350 gestantes a las 16 semanas de gestación halló concentraciones plasmáticas de colesterol total superiores en preeclampsia (220,46 ± 51,06 mg/dl vs 201,35 ± 42,89 mg/dl, p = 0,023) 23 , y otro demostró un aumento de riesgo de preeclampsia 3,6 veces superior para concentraciones séricas de colesterol total > 205 mg/dl (OR: 3,60; IC 95%: 1,23-10,51) 22 . De forma paralela, se han descrito en estudios aislados concentraciones más elevadas de cLDL en las gestantes con preeclampsia 14,26,27 , e incremento del riesgo de preeclampsia de entre 2 y 3 veces para concentraciones elevadas de cLDL 17,23 .…”

Section: Figuraunclassified

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Comportamiento de los lípidos durante la gestación y su relación con acontecimientos obstétricos desfavorables

Ferriols

Rueda

Gamero

et al. 2016

Clínica e Investigación en Arteriosclerosis

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Lipids play an important role during pregnancy, and in this period major changes occur in lipoprotein metabolism. During the third trimester plasma cholesterol and triglyceride levels are substantially increased, returning to normal after delivery. Described associations between increased morbidity during pregnancy and excessive increases in plasma cholesterol and triglycerides. For this reason we have reviewed the relationship between lipid alterations, preeclampsia, gestational diabetes and preterm birth. The overall metabolic control can improve pregnancy outcomes, and the assessment of supraphysiological changes in lipid profile will classify pregnancy risk at a higher level, which would entail a stricter control.

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Serum lipids level assessed in early pregnancy and risk of pre‐eclampsia

Abstract: Early pregnancy dyslipidemia, particularly hypertriglyceridemia appears associated with increased risk of pre-eclampsia.

Cited by 30 publications

References 40 publications

Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia

Metabolomic Biomarkers in Serum and Urine in Women with Preeclampsia

Mitochondrial Long Chain Fatty Acid Oxidation Related Enzyme Changes in Different Preeclampsia-Like Mouse Models

Comportamiento de los lípidos durante la gestación y su relación con acontecimientos obstétricos desfavorables

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