Serum Lipids in Hypothyroidism—A Re-evaluation*

Kutty, Kutty M.; Brayant, David G.; Farid, N.R.

doi:10.1210/jcem-46-1-55

Cited by 116 publications

(53 citation statements)

References 5 publications

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“…The conclusion from that study was that the group of individuals with elevated cholesterol levels may, in fact, include patients with a mild form of subclinical hypothyroidism. Several studies have shown that T 4 administration to the group of subjects with subclinical hypothyroidism was accompanied by a significant lowering of cholesterol levels (10,(13)(14)(15)(16). Our study, which focused on a different group of patients i.e.…”

Section: Discussionmentioning

confidence: 99%

High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

Michalopoulou¹,

Alevizaki²,

Piperingos³

et al. 1998

European Journal of Endocrinology

145

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Objective: The association between established hypothyroidism and high cholesterol levels is well known. The aim of the present study was to investigate the effect of thyroxine (T 4 ) administration on cholesterol levels in hypercholesterolemic subjects with TSH levels within the normal range ('highnormal' TSH compared with 'low-normal' TSH). Design and Methods: We determined TSH levels in 110 consecutive patients referred for hypercholesterolemia (serum cholesterol >7.5 mmol/l). Those with 'high-normal' TSH (2.0-4.0 mU/ml) as well as those with 'low-normal' TSH (0.40-1.99 mU/ml) were randomly assigned to receive either 25 or 50 mg T 4 daily for two months. Thus, groups A and B (low-normal TSH) received 25 and 50 mg T 4 respectively and groups C and D (high-normal TSH) received 25 and 50 mg T 4 respectively. Serum T 4 , tri-iodothyronine (T 3 ), TSH, free thyroxine index, resin T 3 uptake and thyroid autoantibodies (ThAab) as well as total cholesterol, high and low density lipoprotein cholesterol (HDL, LDL), and triglycerides were determined before and at the end of the two-month treatment period. Results: TSH levels were reduced in all groups. The most striking effect was observed in group D (TSH levels before: 2.77 Ϯ 0.55, after: 1.41 Ϯ 0.85 mU/ml, P < 0:01). Subjects in groups C and D had a higher probability of having positive ThAabs. A significant reduction in total cholesterol (P < 0:01) and LDL (P < 0:01) was observed after treatment only in group D. In those subjects in group D who were ThAab negative, there was no significant effect of thyroxine on cholesterol levels. Conclusions: Subjects with high-normal TSH levels combined with ThAabs may, in fact, have subclinical hypothyroidism presenting with elevated cholesterol levels. It is possible that these patients might benefit from thyroxine administration.

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Section: Discussionmentioning

confidence: 99%

High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

Michalopoulou¹,

Alevizaki²,

Piperingos³

et al. 1998

European Journal of Endocrinology

145

View full text Add to dashboard Cite

show abstract

“…and may lead to myocardial ischemia [14][15][16][17], but hypothyroidism may also protect the heart muscle by reducing its work load and oxygen consumption [17,18]. Subclinical hypothyroidism is defined as a generally asymptomatic state characterized by normal serum concentrations of total and free T4 and an increased serum concentration of TSH.…”

Section: Overt Hypothyroidism With Hypercholesterolemia Is Atherogenicmentioning

confidence: 99%

Decrease in Serum Levels of Thyroid Hormone in Patients with Coronary Heart Disease.

et al. 1996

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Abstract. The aim of this study was to evaluate the relationship between subclinical hypothyroidism and/or autoimmune thyroid disease and coronary heart disease (CHD). Ninety seven patients diagnosed as having CHD by a coronary angiography (CHD group) and 103 healthy subjects matched for age, sex and body mass index (control group) were included in the study. Thyroid function, thyroid autoantibodies and serum lipid concentrations were measured in the CHD and control groups. The CHD group exhibited significantly decreased serum free T3 (FT3) and free T4 (FT4) levels, and significantly increased serum TSH levels as compared with the control group, indicating a significant decrease in thyroid function in the CHD patients. Serum high density lipoprotein cholesterol (HDL-C) levels were significantly decreased in the CHD group. The incidence of subclinical hypothyroidism and thyroid autoantibodies was similar in both two groups. These observations were also true of women even after those who had diabetes mellitus (DM), hypertension (HT) and a smoking habit were excluded. This was not the case, however, in men without DM, HT, or a smoking habit. Patients with CHD had significantly lower serum levels of HDL-C than the control subjects, regardless of gender (P<0.01). In the group with CHD, there was no difference between the serum lipid levels in patients with subclinical hypothyroidism and those with normal thyroid function. Female patients with CHD had significantly lower serum levels of thyroid hormone and HDL-C, but their subclinical hypothyroidism or thyroid autoimmunity did not seem to be related to the development of CHD.

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“…In another study conducted by Bahemuka and Hodkinson [16], 2.3% of elderly women had hypothyroidism. Kutty et al [17] showed that clinically overt hypothyroidism in patients is associated with hyperlipidemia.…”

Section: Discussionmentioning

confidence: 99%

Study of Thyroid Profile in Geriatric Type-2 Diabetics in Jharkhand

Jha¹,

Mandal²

2017

Asian J Pharm Clin Res

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Objective: To study the association of the two endocrinal disorders (diabetes mellitus and thyroid disease) in randomly selected geriatric patients. Methods:The study includes 80 patients in geriatric age groups with Type-2 diabetes mellitus visiting the medicine outpatients department. Thyroid profile was assayed in Type-2 diabetic patients.Results: It was noted that thyroid dysfunction was prevalent in 41 (51.25%) out of the 80 geriatric age group patients with 31 (38.75%) being hypothyroidism, 7 (8.7%) having subclinical hypothyroidism, and 3 (3.7%) having a hyperthyroid state. Conclusion:The study shows that screening should be strongly recommended for all Type-2 diabetics to rule out thyroid dysfunction in patients with increasing age.

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Serum Lipids in Hypothyroidism—A Re-evaluation*

Cited by 116 publications

References 5 publications

High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

High serum cholesterol levels in persons with 'high-normal' TSH levels: should one extend the definition of subclinical hypothyroidism?

Decrease in Serum Levels of Thyroid Hormone in Patients with Coronary Heart Disease.

Study of Thyroid Profile in Geriatric Type-2 Diabetics in Jharkhand

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