Serum lipids and anticonvulsants

Berlit, Peter; Krause, Klaus-Henning; Heuck, C. C.; Schellenberg, B.

doi:10.1111/j.1600-0404.1982.tb06852.x

Cited by 22 publications

(4 citation statements)

References 19 publications

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“…The absence of a significant association of long‐term VPA therapy with mean levels of serum lipids in our study is in line with previous data (Berlit et al, 1982; Reddy, 1985).…”

Section: Discussionsupporting

confidence: 93%

Endocrine Effects of Valproate in Adolescent Girls with Epilepsy

et al. 2007

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Summary: Purpose:To investigate the effect of epilepsy and/or valproate (VPA) monotherapy on physical growth, weight gain, pubertal development, and hormonal status in adolescent girls with epilepsy.Methods: The study group included 88 consecutive female patients with epilepsy aged 6-20 years (28 premenarche, 60 postmenarche) attending an endocrinology institute of a major tertiary center. Forty-five patients were under treatment with VPA, and 43 were before treatment initiation. The groups were compared for the relevant biochemical, anthropometric, ultrasonographic, and endocrine parameters.Results: No statistically significant differences were found in any of the parameters studied between the groups, as a whole or by menarche status. The treated postmenarcheal subgroup had a higher mean testosterone level than the untreated postmenarcheal controls (1.83 ± 0.65 vs. 0.88 ± 0.24, p = 0.006). Body mass index-standard deviation score (BMI-SDS) was 0.75 in the treated group and 0.63 in the untreated group; rates of obesity were 16.3% and 15.5%, respectively. No between-group differences were found in menses irregularities, hirsutism, or acne. No correlation was found between duration or dosage of treatment and BMI-SDS, height-SDS, or androgen level. The treated group had higher levels of thyroid-stimulating hormone and lower levels of free thyroxine than did the untreated group, although still within normal range.Conclusions: Long-term treatment with VPA in girls with epilepsy is associated with increased testosterone levels after menarche, without clinical hyperandrogenism, polycystic ovary syndrome, or an increase in BMI-SDS. VPA is a good treatment option in this age group but should be accompanied by careful endocrine observation.

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“…The absence of a significant association of long‐term VPA therapy with mean levels of serum lipids in our study is in line with previous data (Berlit et al, 1982; Reddy, 1985).…”

Section: Discussionsupporting

confidence: 93%

Endocrine Effects of Valproate in Adolescent Girls with Epilepsy

et al. 2007

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“…Third, the methodology varied widely between the included studies, so did the effective dose, and compliance rates. Yet, we found 8 studies that reported higher risk of dyslipidemia with use of AED, irrespective of the type used (Apeland et al, 2002;Berilgen et al, 2006;Berlit et al, 1982;Hamed et al, 2005;Luoma et al, 1980Luoma et al, , 1979aPaknahad et al, 2012;Tan et al, 2009), suggesting that AED use can be deleterious, irrespective of the AED used. Finally, we included only those studies that were in English language possibly missing some studies.…”

Section: Discussionmentioning

confidence: 58%

Antiepileptic drug use for treatment of epilepsy and dyslipidemia: Systematic review

et al. 2015

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“…Children receiving phenytoin had higher mean HDL-C and LDL-C, than the control and valproic acid group in one study [10] . Franzoni E et al [15], Berlit P et al [16] and Pelkonen R et al [17] showed similar results.…”

Section: Research Articlementioning

confidence: 65%

Effect of Antiepileptic drugs on lipid profile in children with Epilepsy

et al. 2014

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Objective: The study evaluated the effect of antiepileptic drugs on lipid profile in children with epilepsy. Demographic profileand the seizure pattern of CWE were also studied. Material and method: 95 children aged between 2-15 years with confirmed diagnosis of primary epilepsy who were on AED for at least 3months were the cases and 50 normal healthy children of similar age group were the controls. Children with BMI >95 th centile were excluded. The cases were categorized in three groups depending upon whether they were taking either phenytoin, valproic acid alone or in combination. Results: The Levene ' s test for homogeneity of variance indicated a significant difference in variance between the cases and control group in serum TGs, LDL-C and VLDL-C. The t-test showed a significant difference in means among cases and controls in HDL-C, LDL-C levels and the risk ratio. Conclusion: We recommend a need for careful monitoring of lipid profile in children with epilepsy receiving antiepileptic drugs.

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Serum lipids and anticonvulsants

Cited by 22 publications

References 19 publications

Endocrine Effects of Valproate in Adolescent Girls with Epilepsy

Endocrine Effects of Valproate in Adolescent Girls with Epilepsy

Antiepileptic drug use for treatment of epilepsy and dyslipidemia: Systematic review

Effect of Antiepileptic drugs on lipid profile in children with Epilepsy

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